dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: DNMT1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.1345C>T p.L449F CCLE PASSENGER/OTHER Possibly Damaging 2 A375 SKIN c.2683C>T p.P895S CCLE NP Probably Damaging 3 CALU6 LUNG c.3797C>T p.S1266F CCLE NP NP 4 GP2D LARGE INTESTINE c.248A>G p.D83G CCLE NP NP 5 GP2D LARGE INTESTINE c.3029G>A p.G1010D CCLE NP NP 6 HEC251 ENDOMETRIUM c.1315G>A p.D439N CCLE NP NP 7 HS944T SKIN c.1694C>T p.S565F CCLE NP NP 8 JHUEM2 ENDOMETRIUM c.891C>A p.S297S CCLE NP NP 9 KLE ENDOMETRIUM c.4894G>C p.D1632H CCLE NP NP 10 KP4 PANCREAS c.445C>T p.R149W CCLE NP NP 11 KYSE180 OESOPHAGUS c.954_954delA p.K318fs CCLE NP NP 12 LP1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.919A>G p.K307E CCLE NP NP 13 LU99 LUNG c.4001C>T p.A1334V CCLE NP NP 14 MFE319 ENDOMETRIUM c.2135T>C p.M712T CCLE PASSENGER/OTHER Benign 15 MFE319 ENDOMETRIUM c.3553A>G p.M1185V CCLE NP NP 16 MOLT13 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3697G>A p.V1233M CCLE NP NP 17 NALM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3467G>A p.R1156Q CCLE NP NP 18 NCIH196 LUNG c.4293_splice p.K1431_splice CCLE NP NP 19 NCIH2106 LUNG c.981T>G p.I327M CCLE NP NP 20 NCIH2110 LUNG c.4174G>C p.E1392Q CCLE NP NP 21 NCIH82 LUNG c.846G>A p.L282L CCLE NP NP 22 NIHOVCAR3 OVARY c.341G>A p.R114K CCLE PASSENGER/OTHER Benign 23 NUGC3 STOMACH c.4223C>A p.P1408H CCLE NP NP 24 ONCODG1 OVARY c.341G>A p.R114K CCLE PASSENGER/OTHER Benign 25 PECAPJ49 UPPER AERODIGESTIVE TRACT c.981T>G p.I327M CCLE NP NP 26 REH HAEMATOPOIETIC AND LYMPHOID TISSUE c.328G>A p.G110R CCLE PASSENGER/OTHER Probably Damaging 27 SKES1 BONE c.2811_2815delCCTCT p.V937fs CCLE NP NP 28 SNU886 LIVER c.410C>G p.T137R CCLE PASSENGER/OTHER Benign 29 SW620 LARGE INTESTINE c.1807C>A p.L603M CCLE NP NP 30 VMRCLCP LUNG c.710A>T p.E237V CCLE NP NP 31 WM1799 SKIN c.3343C>T p.P1115S CCLE NP NP 32 100843 LUNG c.2339C>T p.T780M COSMIC PASSENGER/OTHER Possibly Damaging 33 103812 BREAST c.4652G>A p.R1551Q COSMIC PASSENGER/OTHER Probably Damaging 34 112032 PROSTATE c.1848G>A p.T616T COSMIC NP NP 35 587222 LARGE INTESTINE c.737G>A p.R246Q COSMIC PASSENGER/OTHER Benign 36 587226 LARGE INTESTINE c.2873G>A p.R958H COSMIC PASSENGER/OTHER Probably Damaging 37 587342 LARGE INTESTINE c.2105A>T p.D702V COSMIC PASSENGER/OTHER Probably Damaging 38 587342 LARGE INTESTINE c.3937G>A p.A1313T COSMIC PASSENGER/OTHER Possibly Damaging 39 587376 LARGE INTESTINE c.2975G>A p.R992Q COSMIC PASSENGER/OTHER Probably Damaging 40 587376 LARGE INTESTINE c.4283T>A p.I1428N COSMIC PASSENGER/OTHER Probably Damaging 41 B2 KIDNEY c.860G>A p.R287K COSMIC PASSENGER/OTHER Possibly Damaging 42 BN40T LIVER c.4273A>G p.M1425V COSMIC PASSENGER/OTHER Possibly Damaging 43 CP66-MEL SKIN c.4589C>T p.P1530L COSMIC PASSENGER/OTHER Probably Damaging 44 Case2 BREAST c.1147A>G p.N383D COSMIC PASSENGER/OTHER Benign 45 ESO-0129 OESOPHAGUS c.1601C>T p.T534M COSMIC PASSENGER/OTHER Probably Damaging 46 ESO-1060 OESOPHAGUS c.2415C>T p.L805L COSMIC NP NP 47 ESO-1096 OESOPHAGUS c.276G>T p.L92F COSMIC PASSENGER/OTHER Possibly Damaging 48 ESO-143 OESOPHAGUS c.3247T>A p.F1083I COSMIC PASSENGER/OTHER Probably Damaging 49 ESO-167 OESOPHAGUS c.3617C>T p.S1206F COSMIC PASSENGER/OTHER Possibly Damaging 50 ESO-859 OESOPHAGUS c.1696G>A p.E566K COSMIC PASSENGER/OTHER Benign 51 ESO-859 OESOPHAGUS c.2262G>A p.A754A COSMIC NP NP 52 GC8_T STOMACH c.290A>G p.H97R COSMIC PASSENGER/OTHER Possibly Damaging 53 HCC107T LIVER c.3450_3451insG p.L1151fs*12 COSMIC NP NP 54 HCC40T LIVER c.1897G>A p.A633T COSMIC PASSENGER/OTHER Benign 55 HCC61T LIVER c.417G>T p.R139S COSMIC PASSENGER/OTHER Probably Damaging 56 HCT-15 LARGE INTESTINE c.4801C>T p.R1601* COSMIC NP NP 57 HX11T LIVER c.2873G>A p.R958H COSMIC PASSENGER/OTHER Probably Damaging 58 ID14 HAEMATOPOIETIC AND LYMPHOID TISSUE c.4309C>T p.R1437C COSMIC PASSENGER/OTHER Probably Damaging 59 LAU165 SKIN c.4677C>T p.F1559F COSMIC NP NP 60 LC_C9 LUNG c.1915G>T p.D639Y COSMIC PASSENGER/OTHER Benign 61 LUAD-5V8LT LUNG c.3G>T p.M1I COSMIC PASSENGER/OTHER Possibly Damaging 62 LUAD-B00523 LUNG c.4170G>T p.G1390G COSMIC NP NP 63 LUAD-B01811 LUNG c.858C>T p.H286H COSMIC NP NP 64 LUAD-RT-S01769 LUNG c.1266C>T p.I422I COSMIC NP NP 65 LUAD-RT-S01818 LUNG c.3480C>T p.I1160I COSMIC NP NP 66 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2189G>A p.R730H COSMIC PASSENGER/OTHER Probably Damaging 67 NB-1977 AUTONOMIC GANGLIA c.1372C>A p.L458I COSMIC PASSENGER/OTHER Benign 68 PD3856a BREAST c.3002G>T p.C1001F COSMIC PASSENGER/OTHER Benign 69 PD4099a BREAST c.2961C>G p.A987A COSMIC NP NP 70 PD4136a BREAST c.929A>G p.Q310R COSMIC PASSENGER/OTHER Benign 71 RK159_C01 LIVER c.552T>C p.S184S COSMIC NP NP 72 S00841 LUNG c.1719G>T p.Q573H COSMIC PASSENGER/OTHER Possibly Damaging 73 S00936 LUNG c.2381C>T p.A794V COSMIC PASSENGER/OTHER Possibly Damaging 74 TCGA-05-4410-01 LUNG c.3964G>C p.E1322Q COSMIC PASSENGER/OTHER Benign 75 TCGA-09-1666-01 OVARY c.4145C>T p.S1382L COSMIC PASSENGER/OTHER Probably Damaging 76 TCGA-18-3408-01 LUNG c.1145C>G p.T382R COSMIC PASSENGER/OTHER Possibly Damaging 77 TCGA-18-3411-01 LUNG c.3303C>A p.N1101K COSMIC PASSENGER/OTHER Benign 78 TCGA-21-1077-01 LUNG c.2507A>T p.Y836F COSMIC PASSENGER/OTHER Benign 79 TCGA-24-2035-01 OVARY c.1567A>G p.T523A COSMIC PASSENGER/OTHER Benign 80 TCGA-33-4583-01 LUNG c.3386A>G p.E1129G COSMIC PASSENGER/OTHER Benign 81 TCGA-38-4628-01 LUNG c.3223T>G p.Y1075D COSMIC PASSENGER/OTHER Possibly Damaging 82 TCGA-49-6742-01 LUNG c.498C>T p.T166T COSMIC NP NP 83 TCGA-78-7155-01 LUNG c.3066C>T p.Y1022Y COSMIC NP NP 84 TCGA-A2-A25B-01 BREAST c.414C>T p.P138P COSMIC NP NP 85 TCGA-A5-A0GV-01 ENDOMETRIUM c.1068C>T p.C356C COSMIC NP NP 86 TCGA-A5-A0R9-01 ENDOMETRIUM c.4456G>A p.D1486N COSMIC PASSENGER/OTHER Possibly Damaging 87 TCGA-A6-2683-01 LARGE INTESTINE c.260A>G p.N87S COSMIC PASSENGER/OTHER Probably Damaging 88 TCGA-A8-A097-01 BREAST c.3792C>A p.L1264L COSMIC NP NP 89 TCGA-AA-3492-01 LARGE INTESTINE c.1591A>G p.I531V COSMIC PASSENGER/OTHER Possibly Damaging 90 TCGA-AA-3492-01 LARGE INTESTINE c.807C>T p.G269G COSMIC NP NP 91 TCGA-AA-3554-01 LARGE INTESTINE c.2553C>T p.P851P COSMIC NP NP 92 TCGA-AA-3555-01 LARGE INTESTINE c.4591G>C p.E1531Q COSMIC PASSENGER/OTHER Probably Damaging 93 TCGA-AA-3672-01 LARGE INTESTINE c.1294G>A p.E432K COSMIC PASSENGER/OTHER Benign 94 TCGA-AA-3713-01 LARGE INTESTINE c.3237C>T p.G1079G COSMIC NP NP 95 TCGA-AA-3845-01 LARGE INTESTINE c.3866G>A p.R1289H COSMIC PASSENGER/OTHER Probably Damaging 96 TCGA-AA-3864-01 LARGE INTESTINE c.2574C>T p.D858D COSMIC NP NP 97 TCGA-AA-3877-01 LARGE INTESTINE c.1660G>C p.A554P COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-AA-3956-01 LARGE INTESTINE c.1660G>A p.A554T COSMIC PASSENGER/OTHER Probably Damaging 99 TCGA-AA-3966-01 LARGE INTESTINE c.768_769delGA p.K257fs*16 COSMIC NP NP 100 TCGA-AA-A00J-01 LARGE INTESTINE c.3316C>T p.P1106S COSMIC PASSENGER/OTHER Benign 101 TCGA-AA-A00N-01 LARGE INTESTINE c.1294G>A p.E432K COSMIC PASSENGER/OTHER Benign 102 TCGA-AA-A010-01 LARGE INTESTINE c.3710C>T p.S1237L COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-AA-A01Q-01 LARGE INTESTINE c.1550A>C p.Q517P COSMIC PASSENGER/OTHER Probably Damaging 104 TCGA-AA-A01Z-01 LARGE INTESTINE c.1294G>A p.E432K COSMIC PASSENGER/OTHER Benign 105 TCGA-AB-2833-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.499A>T p.I167F COSMIC PASSENGER/OTHER Probably Damaging 106 TCGA-AF-2689-01 LARGE INTESTINE c.319C>G p.L107V COSMIC PASSENGER/OTHER Possibly Damaging 107 TCGA-AG-3609-01 LARGE INTESTINE c.4591G>C p.E1531Q COSMIC PASSENGER/OTHER Probably Damaging 108 TCGA-AG-3882-01 LARGE INTESTINE c.4097C>T p.T1366M COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-AG-A002-01 LARGE INTESTINE c.1453G>A p.E485K COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-AG-A002-01 LARGE INTESTINE c.689G>A p.R230H COSMIC PASSENGER/OTHER Benign 111 TCGA-AG-A02N-01 LARGE INTESTINE c.407G>A p.R136H COSMIC PASSENGER/OTHER Possibly Damaging 112 TCGA-AG-A02N-01 LARGE INTESTINE c.4103G>A p.R1368Q COSMIC PASSENGER/OTHER Probably Damaging 113 TCGA-AN-A0XW-01 BREAST c.2505C>T p.I835I COSMIC NP NP 114 TCGA-AP-A051-01 ENDOMETRIUM c.2787C>T p.N929N COSMIC NP NP 115 TCGA-AP-A056-01 ENDOMETRIUM c.151G>A p.E51K COSMIC PASSENGER/OTHER Probably Damaging 116 TCGA-AP-A059-01 ENDOMETRIUM c.1137G>A p.Q379Q COSMIC NP NP 117 TCGA-AP-A0LM-01 ENDOMETRIUM c.4358G>T p.R1453M COSMIC PASSENGER/OTHER Possibly Damaging 118 TCGA-AP-A0LM-01 ENDOMETRIUM c.4394G>A p.G1465D COSMIC PASSENGER/OTHER Probably Damaging 119 TCGA-AR-A251-01 BREAST c.2318C>T p.P773L COSMIC PASSENGER/OTHER Probably Damaging 120 TCGA-AU-6004-01 LARGE INTESTINE c.687G>A p.T229T COSMIC NP NP 121 TCGA-AZ-4315-01 LARGE INTESTINE c.2873G>A p.R958H COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-B0-4712-01 KIDNEY c.2702A>C p.E901A COSMIC PASSENGER/OTHER Benign 123 TCGA-B0-5095-01 KIDNEY c.2088G>A p.M696I COSMIC PASSENGER/OTHER Benign 124 TCGA-B0-5709-01 KIDNEY c.647C>A p.P216Q COSMIC PASSENGER/OTHER Benign 125 TCGA-B5-A0JZ-01 ENDOMETRIUM c.2364C>T p.N788N COSMIC NP NP 126 TCGA-BG-A0LX-01 ENDOMETRIUM c.2895T>A p.D965E COSMIC PASSENGER/OTHER Probably Damaging 127 TCGA-BG-A0W1-01 ENDOMETRIUM c.2787C>T p.N929N COSMIC NP NP 128 TCGA-BH-A0GY-01 BREAST c.4036G>C p.D1346H COSMIC PASSENGER/OTHER Probably Damaging 129 TCGA-BS-A0UF-01 ENDOMETRIUM c.151G>A p.E51K COSMIC PASSENGER/OTHER Probably Damaging 130 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1435T>C p.F479L COSMIC PASSENGER/OTHER Possibly Damaging 131 TCGA-BS-A0UM-01 ENDOMETRIUM c.897C>T p.P299P COSMIC NP NP 132 TCGA-BS-A0UV-01 ENDOMETRIUM c.3045A>C p.K1015N COSMIC PASSENGER/OTHER Possibly Damaging 133 TCGA-CA-6718-01 LARGE INTESTINE c.1732A>G p.T578A COSMIC PASSENGER/OTHER Benign 134 TCGA-CH-5769-01 PROSTATE c.2189G>A p.R730H COSMIC PASSENGER/OTHER Probably Damaging 135 TCGA-CJ-5682-01 KIDNEY c.3886T>C p.F1296L COSMIC PASSENGER/OTHER Possibly Damaging 136 TCGA-CK-5913-01 LARGE INTESTINE c.4721G>A p.R1574Q COSMIC PASSENGER/OTHER Probably Damaging 137 TCGA-CK-5913-01 LARGE INTESTINE c.890G>A p.R297Q COSMIC PASSENGER/OTHER Possibly Damaging 138 TCGA-CM-4743-01 LARGE INTESTINE c.2152delA p.M718fs*59 COSMIC NP NP 139 TCGA-CM-5861-01 LARGE INTESTINE c.2875C>T p.P959S COSMIC PASSENGER/OTHER Benign 140 TCGA-CM-6674-01 LARGE INTESTINE c.2619C>T p.Y873Y COSMIC NP NP 141 TCGA-CZ-5986-01 KIDNEY c.4520A>G p.H1507R COSMIC PASSENGER/OTHER Probably Damaging 142 TCGA-D1-A103-01 ENDOMETRIUM c.1073A>G p.Q358R COSMIC PASSENGER/OTHER Benign 143 TCGA-D1-A103-01 ENDOMETRIUM c.1453G>A p.E485K COSMIC PASSENGER/OTHER Probably Damaging 144 TCGA-D1-A103-01 ENDOMETRIUM c.369A>G p.A123A COSMIC NP NP 145 TCGA-D1-A103-01 ENDOMETRIUM c.4766G>A p.G1589D COSMIC PASSENGER/OTHER Probably Damaging 146 TCGA-D1-A103-01 ENDOMETRIUM c.497C>T p.T166I COSMIC PASSENGER/OTHER Benign 147 TCGA-D1-A16X-01 ENDOMETRIUM c.1770C>T p.V590V COSMIC NP NP 148 TCGA-D1-A17Q-01 ENDOMETRIUM c.151G>A p.E51K COSMIC PASSENGER/OTHER Probably Damaging 149 TCGA-D1-A17Q-01 ENDOMETRIUM c.1885G>A p.D629N COSMIC PASSENGER/OTHER Probably Damaging 150 TCGA-D1-A17U-01 ENDOMETRIUM c.4560C>T p.D1520D COSMIC NP NP 151 TCGA-D5-6540-01 LARGE INTESTINE c.566C>T p.S189L COSMIC PASSENGER/OTHER Benign 152 TCGA-DK-A3IS-01 URINARY TRACT c.1408G>A p.D470N COSMIC PASSENGER/OTHER Probably Damaging 153 TCGA-DK-A3IT-01 URINARY TRACT c.508C>G p.H170D COSMIC PASSENGER/OTHER Possibly Damaging 154 TCGA-DK-A3IT-01 URINARY TRACT c.541C>G p.Q181E COSMIC PASSENGER/OTHER Benign 155 TCGA-DM-A28F-01 LARGE INTESTINE c.957A>G p.E319E COSMIC NP NP 156 TCGA-EI-6510-01 LARGE INTESTINE c.4145C>T p.S1382L COSMIC PASSENGER/OTHER Probably Damaging 157 TCGA-EJ-5505-01 PROSTATE c.1747G>A p.D583N COSMIC PASSENGER/OTHER Possibly Damaging 158 TCGA-EW-A1PA-01 BREAST c.2575G>A p.D859N COSMIC PASSENGER/OTHER Benign 159 TCGA-F4-6856-01 LARGE INTESTINE c.4146G>A p.S1382S COSMIC NP NP 160 TCGA-F5-6571-01 LARGE INTESTINE c.3672G>C p.P1224P COSMIC NP NP 161 TCGA-FI-A2F8-01 ENDOMETRIUM c.3620G>A p.R1207H COSMIC PASSENGER/OTHER Probably Damaging 162 TCGA-G2-A2EO-01 URINARY TRACT c.3531C>T p.F1177F COSMIC NP NP 163 TCGA-G9-6332-01 PROSTATE c.1016G>C p.R339P COSMIC PASSENGER/OTHER Benign 164 TCGA-GC-A3I6-01 URINARY TRACT c.1164C>G p.I388M COSMIC PASSENGER/OTHER Benign 165 WA43-27 PROSTATE c.4039G>A p.D1347N COSMIC PASSENGER/OTHER Benign 166 WA43-27 PROSTATE c.4044G>A p.K1348K COSMIC NP NP 167 WA43-44 PROSTATE c.4039G>A p.D1347N COSMIC PASSENGER/OTHER Benign 168 WA43-44 PROSTATE c.4044G>A p.K1348K COSMIC NP NP 169 WA43-71 PROSTATE c.4039G>A p.D1347N COSMIC PASSENGER/OTHER Benign 170 WA43-71 PROSTATE c.4044G>A p.K1348K COSMIC NP NP 171 cSCCP1 SKIN c.3514C>T p.P1172S COSMIC PASSENGER/OTHER Benign 172 cSCCP6 SKIN c.2960_2961CC>TT p.A987V COSMIC PASSENGER/OTHER Possibly Damaging 173 cSCCP7 SKIN c.1609C>T p.P537S COSMIC PASSENGER/OTHER Probably Damaging 174 pfg019T STOMACH c.2152delA p.M718fs*59 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR DNMT1 DNMT1 DNMT1 ENSP00000345739 P26358 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt P26358 DNMT1 ENSP00000345739 DNMT1 P26358 Expression Atlas Protein Atlas OMIM IntAct PharmGKB DNMT1 ENSP00000345739 126375 P26358 PA27443
