dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CDYL |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334194 LUNG c.143T>C p.V48A COSMIC PASSENGER/OTHER Benign 2 2334194 LUNG c.179C>G p.A60G COSMIC PASSENGER/OTHER Benign 3 2334194 LUNG c.25T>C p.S9P COSMIC PASSENGER/OTHER Benign 4 2334194 LUNG c.4A>G p.T2A COSMIC PASSENGER/OTHER Benign 5 587222 LARGE INTESTINE c.985C>T p.R329C COSMIC PASSENGER/OTHER Benign 6 587284 LARGE INTESTINE c.478G>A p.E160K COSMIC PASSENGER/OTHER Benign 7 587304 LARGE INTESTINE c.745G>A p.A249T COSMIC PASSENGER/OTHER Benign 8 587374 LARGE INTESTINE c.946A>T p.I316F COSMIC PASSENGER/OTHER Benign 9 ESO-114 OESOPHAGUS c.1065C>G p.I355M COSMIC PASSENGER/OTHER Probably Damaging 10 ESO03T OESOPHAGUS c.847G>A p.G283R COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
Tissue Type Mean Expression Value Median Expression Value Mean CNV Median CNV AUTONOMIC GANGLIA 8.3960 8.4283 -0.0590 -0.06139 BILIARY TRACT 8.8174 8.8682 -0.1138 -0.1277 BONE 8.5358 8.5646 -0.0741 -0.01209 BREAST 8.8028 8.8909 0.0317 0.01948625 CENTRAL NERVOUS SYSTEM 8.6690 8.6805 0.0827 0.1021 ENDOMETRIUM 8.9131 8.9231 0.0820 0.02306 HAEMATOPOIETIC AND LYMPHOID TISSUE 8.9317 8.9931 0.0689 0.01243 KIDNEY 8.4465 8.3475 -0.0355 0.04317 LARGE INTESTINE 8.6650 8.6188 -0.1450 -0.0419 LIVER 8.7196 8.8408 0.1678 0.1484 
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test
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Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR CDYL CDYL CDYL ENSP00000330512 Q9Y232 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9Y232 CDYL ENSP00000330512 CDYL Q9Y232 Expression Atlas Protein Atlas OMIM IntAct PharmGKB CDYL ENSP00000330512 603778 Q9Y232 PA26356