dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CARM1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.992A>G p.Q331R CCLE NP NP 2 647V URINARY TRACT c.1006G>T p.E336* CCLE NP NP 3 COLO741 SKIN c.963_964insAA p.K321fs CCLE NP NP 4 CORL47 LUNG c.916C>T p.R306* CCLE NP NP 5 COV504 OVARY c.966_967delAC p.P322fs CCLE NP NP 6 GCT SOFT TISSUE c.948_949CC>TT p.Q317* CCLE NP NP 7 HS746T STOMACH c.955A>T p.K319* CCLE NP NP 8 HSC3 UPPER AERODIGESTIVE TRACT c.915_916insTAAG p.K305fs CCLE NP NP 9 J82 URINARY TRACT c.960G>C p.K320N CCLE NP NP 10 KCL22 HAEMATOPOIETIC AND LYMPHOID TISSUE c.902_902delC p.P301fs CCLE NP NP 11 KNS42 CENTRAL NERVOUS SYSTEM c.1024C>T p.R342* CCLE NP NP 12 KYSE30 OESOPHAGUS c.976G>A p.E326K CCLE NP NP 13 KYSE410 OESOPHAGUS c.1009C>T p.R337C CCLE NP NP 14 MEC1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.949_950insC p.Q317fs CCLE NP NP 15 MEWO SKIN c.949C>T p.Q317* CCLE NP NP 16 MFE296 ENDOMETRIUM c.916C>T p.R306* CCLE NP NP 17 NCIH1184 LUNG c.1001G>T p.G334V CCLE NP NP 18 NCIH1373 LUNG c.1015G>T p.E339* CCLE NP NP 19 NCIH2228 LUNG c.991C>T p.Q331* CCLE NP NP 20 OCILY10 HAEMATOPOIETIC AND LYMPHOID TISSUE c.955A>T p.K319* CCLE NP NP 21 OE19 OESOPHAGUS c.929_930insA p.N310fs CCLE NP NP 22 OVSAHO OVARY c.1024C>T p.R342* CCLE NP NP 23 RCM1 LARGE INTESTINE c.916C>T p.R306* CCLE NP NP 24 REC1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.949C>T p.Q317* CCLE NP NP 25 RMUGS OVARY c.1040C>T p.A347V CCLE NP NP 26 S117 SOFT TISSUE c.976G>T p.E326* CCLE NP NP 27 TEN ENDOMETRIUM c.1024C>T p.R342* CCLE NP NP 28 UACC893 BREAST c.1024C>T p.R342* CCLE NP NP 29 UBLC1 URINARY TRACT c.991C>T p.Q331* CCLE NP NP 30 091 HAEMATOPOIETIC AND LYMPHOID TISSUE c.499G>A p.V167M COSMIC PASSENGER/OTHER Probably Damaging 31 091-01-6TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.499G>A p.V167M COSMIC PASSENGER/OTHER Probably Damaging 32 587228 LARGE INTESTINE c.1439C>T p.T480M COSMIC PASSENGER/OTHER Probably Damaging 33 ESO-859 OESOPHAGUS c.1462C>A p.H488N COSMIC PASSENGER/OTHER Benign 34 HCC104T LIVER c.1327delA p.N443fs*27 COSMIC NP NP 35 HCC132T LIVER c.1020G>T p.V340V COSMIC NP NP 36 HCC4T LIVER c.305T>C p.L102P COSMIC PASSENGER/OTHER Probably Damaging 37 HCC68T LIVER c.1449C>G p.P483P COSMIC NP NP 38 HX13T LIVER c.305T>C p.L102P COSMIC PASSENGER/OTHER Probably Damaging 39 K20 KIDNEY c.978C>G p.L326L COSMIC NP NP 40 LC_S11 LUNG c.701G>C p.R234P COSMIC PASSENGER/OTHER Probably Damaging 41 LPJ119 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1517G>C p.S506T COSMIC PASSENGER/OTHER Benign 42 LUAD-D02185 LUNG c.396G>A p.L132L COSMIC NP NP 43 LUAD-F00057 LUNG c.574G>T p.G192C COSMIC PASSENGER/OTHER Probably Damaging 44 LUAD-S00499 LUNG c.1721C>T p.T574M COSMIC PASSENGER/OTHER Probably Damaging 45 MB_Exm575 CENTRAL NERVOUS SYSTEM c.796G>A p.E266K COSMIC PASSENGER/OTHER Probably Damaging 46 OVCAR-5 OVARY c.254C>T p.S85F COSMIC PASSENGER/OTHER Benign 47 PD4132a BREAST c.636G>A p.A212A COSMIC NP NP 48 PGBM33PT CENTRAL NERVOUS SYSTEM c.1355T>C p.I452T COSMIC PASSENGER/OTHER Possibly Damaging 49 TCGA-05-4384-01 LUNG c.605C>T p.A202V COSMIC PASSENGER/OTHER Probably Damaging 50 TCGA-05-4389-01 LUNG c.607G>C p.A203P COSMIC PASSENGER/OTHER Probably Damaging 51 TCGA-29-1777-01 OVARY c.1156G>A p.G386S COSMIC PASSENGER/OTHER Probably Damaging 52 TCGA-44-8117-01 LUNG c.559A>G p.I187V COSMIC PASSENGER/OTHER Benign 53 TCGA-49-4490-01 LUNG c.605C>T p.A202V COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-55-7574-01 LUNG c.1304C>T p.S435L COSMIC PASSENGER/OTHER Benign 55 TCGA-55-7574-01 LUNG c.1800G>A p.P600P COSMIC NP NP 56 TCGA-61-1914-01 OVARY c.1021G>A p.D341N COSMIC PASSENGER/OTHER Benign 57 TCGA-61-1914-01 OVARY c.630C>G p.I210M COSMIC PASSENGER/OTHER Possibly Damaging 58 TCGA-66-2766-01 LUNG c.1665G>C p.M555I COSMIC PASSENGER/OTHER Benign 59 TCGA-AA-3864-01 LARGE INTESTINE c.1430C>T p.T477M COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-AA-A00A-01 LARGE INTESTINE c.257G>C p.R86P COSMIC PASSENGER/OTHER Benign 61 TCGA-AD-6895-01 LARGE INTESTINE c.873C>T p.D291D COSMIC NP NP 62 TCGA-AP-A051-01 ENDOMETRIUM c.1203C>T p.T401T COSMIC NP NP 63 TCGA-AP-A059-01 ENDOMETRIUM c.1529C>A p.A510D COSMIC PASSENGER/OTHER Benign 64 TCGA-AP-A05N-01 ENDOMETRIUM c.623G>A p.R208Q COSMIC PASSENGER/OTHER Possibly Damaging 65 TCGA-AX-A0J0-01 ENDOMETRIUM c.346G>A p.D116N COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-B5-A0K0-01 ENDOMETRIUM c.1825T>C p.*609Q COSMIC NP NP 67 TCGA-B5-A11E-01 ENDOMETRIUM c.1117C>T p.P373S COSMIC PASSENGER/OTHER Benign 68 TCGA-BH-A0GY-01 BREAST c.726delG p.E243fs*37 COSMIC NP NP 69 TCGA-BL-A13J-01 URINARY TRACT c.1775C>A p.S592Y COSMIC PASSENGER/OTHER Probably Damaging 70 TCGA-BS-A0UF-01 ENDOMETRIUM c.333C>T p.F111F COSMIC NP NP 71 TCGA-E9-A1RG-01 BREAST c.950C>T p.S317F COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-G2-A2EL-01 URINARY TRACT c.424G>A p.E142K COSMIC PASSENGER/OTHER Benign 73 TCGA-GV-A3QH-01 URINARY TRACT c.1583C>G p.S528C COSMIC PASSENGER/OTHER Possibly Damaging 74 TCGA-HQ-A2OE-01 URINARY TRACT c.1350C>T p.I450I COSMIC NP NP 75 pfg017T STOMACH c.228_229insTG p.V77fs*49 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR CARM1 CARM1 CARM1 ENSP00000325690 Q86X55 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q86X55 CARM1 ENSP00000325690 CARM1 Q86X55 Expression Atlas Protein Atlas OMIM IntAct PharmGKB CARM1 ENSP00000325690 603934 Q86X55 PA134959553
