dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: CARM1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.992A>G p.Q331R CCLE NP NP 2 647V URINARY TRACT c.1006G>T p.E336* CCLE NP NP 3 COLO741 SKIN c.963_964insAA p.K321fs CCLE NP NP 4 CORL47 LUNG c.916C>T p.R306* CCLE NP NP 5 COV504 OVARY c.966_967delAC p.P322fs CCLE NP NP 6 GCT SOFT TISSUE c.948_949CC>TT p.Q317* CCLE NP NP 7 HS746T STOMACH c.955A>T p.K319* CCLE NP NP 8 HSC3 UPPER AERODIGESTIVE TRACT c.915_916insTAAG p.K305fs CCLE NP NP 9 J82 URINARY TRACT c.960G>C p.K320N CCLE NP NP 10 KCL22 HAEMATOPOIETIC AND LYMPHOID TISSUE c.902_902delC p.P301fs CCLE NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
Tissue Type Mean Expression Value Median Expression Value Mean CNV Median CNV AUTONOMIC GANGLIA 8.7708 8.8061 -0.1196 -0.0481 BILIARY TRACT 8.6799 8.715 -0.2320 -0.0875 BONE 8.8705 8.9393 -0.0414 -0.0041 BREAST 8.6273 8.71165 -0.0781 0.00235 CENTRAL NERVOUS SYSTEM 8.6447 8.6771 0.0126 0.0093 ENDOMETRIUM 8.9588 8.8434 -0.0427 -0.01885 HAEMATOPOIETIC AND LYMPHOID TISSUE 9.0290 9.0135 0.1043 0.015 KIDNEY 8.5378 8.7648 -0.0285 0.0501 LARGE INTESTINE 9.0850 9.1313 -0.1048 -0.05867 LIVER 8.6103 8.6519 -0.1978 -0.3046 
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test
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Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR CARM1 CARM1 CARM1 ENSP00000325690 Q86X55 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q86X55 CARM1 ENSP00000325690 CARM1 Q86X55 Expression Atlas Protein Atlas OMIM IntAct PharmGKB CARM1 ENSP00000325690 603934 Q86X55 PA134959553