dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTR8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.11C>G p.A4G COSMIC PASSENGER/OTHER Benign 2 Br27P CENTRAL NERVOUS SYSTEM c.1190C>T p.T397I COSMIC CANCER Benign 3 ESO-003 OESOPHAGUS c.1174T>G p.L392V COSMIC CANCER Possibly Damaging 4 ESO-732 OESOPHAGUS c.1168A>G p.M390V COSMIC CANCER Benign 5 N608T AUTONOMIC GANGLIA c.866C>A p.T289K COSMIC CANCER Probably Damaging 6 TARGET-30-PATDWN AUTONOMIC GANGLIA c.1307C>A p.A436E COSMIC PASSENGER/OTHER Benign 7 TCGA-04-1338-01 OVARY c.591T>A p.P197P COSMIC NP NP 8 TCGA-23-1120-01 OVARY c.1573G>C p.D525H COSMIC PASSENGER/OTHER Probably Damaging 9 TCGA-33-6737-01 LUNG c.230G>A p.R77Q COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-39-5019-01 LUNG c.996C>G p.C332W COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
Tissue Type Mean Expression Value Median Expression Value Mean CNV Median CNV AUTONOMIC GANGLIA 7.1679 7.0818 -0.0277 -0.0269 BILIARY TRACT 6.7857 6.778 -0.0101 -0.0304 BONE 7.0379 7.1205 -0.2347 -0.0385 BREAST 6.9029 6.9909 -0.2608 -0.2016 CENTRAL NERVOUS SYSTEM 7.0702 7.0783 -0.0563 -0.0206 ENDOMETRIUM 7.0242 7.0734 -0.0597 -0.0215 HAEMATOPOIETIC AND LYMPHOID TISSUE 7.4192 7.4474 -0.0412 0.006556 KIDNEY 6.5148 6.5425 -0.5769 -0.7168 LARGE INTESTINE 6.9725 7.0122 -0.1281 -0.053355 LIVER 6.7847 6.7742 -0.1840 -0.1657 
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test
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Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ACTR8 ACTR8 ACTR8 ENSP00000336842 Q9H981 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H981 ACTR8 ENSP00000336842 ACTR8 Q9H981 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ACTR8 ENSP00000336842 NA Q9H981 PA24491