dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTR5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1960034 URINARY TRACT c.205C>G p.R69G COSMIC PASSENGER/OTHER Possibly Damaging 2 587222 LARGE INTESTINE c.1349G>A p.R450Q COSMIC PASSENGER/OTHER Probably Damaging 3 587234 LARGE INTESTINE c.1552C>T p.R518W COSMIC PASSENGER/OTHER Possibly Damaging 4 587332 LARGE INTESTINE c.1166G>A p.S389N COSMIC PASSENGER/OTHER Possibly Damaging 5 587342 LARGE INTESTINE c.35G>A p.R12H COSMIC PASSENGER/OTHER Probably Damaging 6 ESO-1608 OESOPHAGUS c.516C>G p.Y172* COSMIC NP NP 7 ESO-408 OESOPHAGUS c.1036C>G p.L346V COSMIC PASSENGER/OTHER Probably Damaging 8 ESO-838 OESOPHAGUS c.1306T>G p.L436V COSMIC PASSENGER/OTHER Benign 9 HCC106T LIVER c.202G>T p.G68C COSMIC PASSENGER/OTHER Probably Damaging 10 HCC10T LIVER c.691C>T p.P231S COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
Tissue Type Mean Expression Value Median Expression Value Mean CNV Median CNV AUTONOMIC GANGLIA 7.1105 7.0085 0.0871 0.01777 BILIARY TRACT 7.3617 7.1263 0.3170 0.2557 BONE 6.6260 6.6023 0.0940 0.0027 BREAST 6.9233 6.84595 0.2605 0.2878 CENTRAL NERVOUS SYSTEM 6.6682 6.5452 0.2658 0.1932 ENDOMETRIUM 6.8743 6.8459 0.1185 0.01358 HAEMATOPOIETIC AND LYMPHOID TISSUE 7.1966 7.233 0.0694 0.02184 KIDNEY 6.4956 6.6538 0.2029 0.1872 LARGE INTESTINE 7.3789 7.39465 0.2815 0.10021 LIVER 7.0290 7.0761 0.4238 0.4804 
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test
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Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB
Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
$x"); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d]"); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo""; include("$dir/ptm.html"); echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ACTR5 ACTR5 ACTR5 ENSP00000243903 Q9H9F9 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H9F9 ACTR5 ENSP00000243903 ACTR5 Q9H9F9 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ACTR5 ENSP00000243903 NA Q9H9F9 PA24490