dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: ACTR5 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1960034 URINARY TRACT c.205C>G p.R69G COSMIC PASSENGER/OTHER Possibly Damaging 2 587222 LARGE INTESTINE c.1349G>A p.R450Q COSMIC PASSENGER/OTHER Probably Damaging 3 587234 LARGE INTESTINE c.1552C>T p.R518W COSMIC PASSENGER/OTHER Possibly Damaging 4 587332 LARGE INTESTINE c.1166G>A p.S389N COSMIC PASSENGER/OTHER Possibly Damaging 5 587342 LARGE INTESTINE c.35G>A p.R12H COSMIC PASSENGER/OTHER Probably Damaging 6 ESO-1608 OESOPHAGUS c.516C>G p.Y172* COSMIC NP NP 7 ESO-408 OESOPHAGUS c.1036C>G p.L346V COSMIC PASSENGER/OTHER Probably Damaging 8 ESO-838 OESOPHAGUS c.1306T>G p.L436V COSMIC PASSENGER/OTHER Benign 9 HCC106T LIVER c.202G>T p.G68C COSMIC PASSENGER/OTHER Probably Damaging 10 HCC10T LIVER c.691C>T p.P231S COSMIC PASSENGER/OTHER Probably Damaging 11 HCC88T LIVER c.1299G>T p.V433V COSMIC NP NP 12 LC_C27 LUNG c.628C>T p.R210C COSMIC PASSENGER/OTHER Probably Damaging 13 LC_C27 LUNG c.629G>C p.R210P COSMIC PASSENGER/OTHER Probably Damaging 14 LUAD-E00443 LUNG c.1682G>T p.G561V COSMIC CANCER Probably Damaging 15 ME030T SKIN c.1240C>T p.P414S COSMIC PASSENGER/OTHER Possibly Damaging 16 SWE-38 PROSTATE c.1541T>G p.M514R COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-38-4632-01 LUNG c.1162G>C p.D388H COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-60-2698-01 LUNG c.924C>A p.L308L COSMIC NP NP 19 TCGA-66-2734-01 LUNG c.1146C>A p.L382L COSMIC NP NP 20 TCGA-85-6175-01 LUNG c.1581G>A p.S527S COSMIC NP NP 21 TCGA-AA-3510-01 LARGE INTESTINE c.385G>A p.D129N COSMIC PASSENGER/OTHER Possibly Damaging 22 TCGA-AA-3811-01 LARGE INTESTINE c.1443G>T p.K481N COSMIC PASSENGER/OTHER Possibly Damaging 23 TCGA-AA-3950-01 LARGE INTESTINE c.579G>A p.T193T COSMIC NP NP 24 TCGA-AA-3984-01 LARGE INTESTINE c.531G>T p.K177N COSMIC PASSENGER/OTHER Benign 25 TCGA-AP-A059-01 ENDOMETRIUM c.579G>A p.T193T COSMIC NP NP 26 TCGA-B0-4706-01 KIDNEY c.926A>G p.N309S COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-B5-A11E-01 ENDOMETRIUM c.690C>T p.Y230Y COSMIC NP NP 28 TCGA-B5-A11N-01 ENDOMETRIUM c.1015A>G p.M339V COSMIC PASSENGER/OTHER Benign 29 TCGA-B8-4621-01 KIDNEY c.1459C>A p.L487M COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-BS-A0UV-01 ENDOMETRIUM c.531G>T p.K177N COSMIC PASSENGER/OTHER Benign 31 TCGA-CI-6622-01 LARGE INTESTINE c.333G>C p.L111F COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-CM-4743-01 LARGE INTESTINE c.1134G>A p.A378A COSMIC NP NP 33 TCGA-D1-A167-01 ENDOMETRIUM c.1580C>T p.S527L COSMIC PASSENGER/OTHER Benign 34 TCGA-D1-A16X-01 ENDOMETRIUM c.645A>G p.G215G COSMIC NP NP 35 TCGA-D1-A17Q-01 ENDOMETRIUM c.1808C>T p.A603V COSMIC PASSENGER/OTHER Benign 36 TCGA-D5-6930-01 LARGE INTESTINE c.1747G>A p.A583T COSMIC PASSENGER/OTHER Benign 37 TCGA-E9-A243-01 BREAST c.756C>A p.I252I COSMIC NP NP 38 TCGA-EJ-7789-01 PROSTATE c.1747G>A p.A583T COSMIC PASSENGER/OTHER Benign 39 XPA27PT1 CENTRAL NERVOUS SYSTEM c.1208T>C p.L403S COSMIC PASSENGER/OTHER Benign 40 XPA27PT2 CENTRAL NERVOUS SYSTEM c.1208T>C p.L403S COSMIC PASSENGER/OTHER Benign 41 YUHEF SKIN c.1222A>G p.S408G COSMIC PASSENGER/OTHER Benign 42 cSCCP1 SKIN c.1205C>T p.S402F COSMIC PASSENGER/OTHER Possibly Damaging 43 ccRCC-29 KIDNEY c.908delG p.R304fs*31 COSMIC NP NP 44 pfg008T STOMACH c.620A>C p.N207T COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
-
Post Translational Modifications (+)
$x "); for($d=2;$d<$l777;$d++) { fwrite($FP6,$row6[$d]); fwrite($FP7,"$row6[$d] "); fwrite($FP6,"\t"); } fwrite($FP6,"\n"); fwrite($FP7,""); } fclose($FP6); echo""; } else{echo"
"; ##### table ##### $ptm_tr=file_get_contents("$dir/ptm"); if($ptm_tr != '') { echo"S. No. Position Amino acid Type Post translational modifications are not found!!";} ?> -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR ACTR5 ACTR5 ACTR5 ENSP00000243903 Q9H9F9 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9H9F9 ACTR5 ENSP00000243903 ACTR5 Q9H9F9 Expression Atlas Protein Atlas OMIM IntAct PharmGKB ACTR5 ENSP00000243903 NA Q9H9F9 PA24490
