Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE


Result Reset Search:
ProteinNeoepitopesTissuePositionProt MutationcDNA MutationMutation TypeNum MismatchPromiscuity (%)Cell LineCTLMHC INHLApredMHC IIBcell
ERBB2AVCVGSPYVLUNG775p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins30.11NCIH1781Y2110N
ERBB2AYVMAVCVGLUNG771p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins40.11NCIH1781N000N
ERBB2CVGSPYVSRLUNG777p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins10.11NCIH1781Y6100N
ERBB2DEAYVMAVCLUNG769p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins20.11NCIH1781N600N
ERBB2EAYVMAVCVLUNG770p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins30.11NCIH1781N600N
ERBB2MAVCVGSPYLUNG774p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins40.11NCIH1781N800N
ERBB2VCVGSPYVSLUNG776p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins20.11NCIH1781N001N
ERBB2VMAVCVGSPLUNG773p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins50.11NCIH1781N000N
ERBB2YVMAVCVGSLUNG772p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins50.11NCIH1781N2048N
ERBB2LDEAYVMAVLUNG768p.776_776G>VCc.2326_2327insTGTIn_Frame_Ins10.22NCIH1781N700N