Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
NF2	ACLSTSKIL	PLEURA	501	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	12	0	0	N
NF2	AGIFGPRGI	LARGE_INTESTINE	159	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	9	0	0	N
NF2	AQSCCLEWM	STOMACH	229	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	6	0	0	N
NF2	ASTSLVTAC	PLEURA	494	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	1	0	0	N
NF2	CCLEWMPWG	STOMACH	232	p.K227fs	c.679_679delA	Frame_Shift_Del	7	0.11	NUGC3	N	0	0	0	N
NF2	CLEWMPWGF	STOMACH	233	p.K227fs	c.679_679delA	Frame_Shift_Del	7	0.11	NUGC3	N	5	0	0	N
NF2	CLLTYQAST	PLEURA	488	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	5	0	0	N
NF2	CLVRRAPRP	LARGE_INTESTINE	189	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	CSQAGIFGP	LARGE_INTESTINE	156	p.P155fs	c.465_466delCA	Frame_Shift_Del	7	0.11	SNUC4	N	0	0	0	N
NF2	DDSGNVGGE	LARGE_INTESTINE	178	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	DPCSQAGIF	LARGE_INTESTINE	154	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	11	0	0	N
NF2	DSGNVGGEN	LARGE_INTESTINE	179	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	EWMPWGFTF	STOMACH	235	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	3	0	0	N
NF2	FRGMKSETS	LUNG	256	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	N	3	0	35	N
NF2	FTFMTLRTD	STOMACH	241	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	2	0	8	N
NF2	GFTFMTLRT	STOMACH	240	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	1	0	0	N
NF2	GIFGPRGIA	LARGE_INTESTINE	160	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	1	0	0	N
NF2	GNVGGENYC	LARGE_INTESTINE	181	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	HRCLLTYQA	PLEURA	486	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	Y	3	10	0	N
NF2	IFGPRGIAS	LARGE_INTESTINE	161	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	Y
NF2	IKHWIRKLM	LARGE_INTESTINE	273	p.P275fs	c.823_823delC	Frame_Shift_Del	6	0.11	RKO	N	5	0	11	N
NF2	KHWIRKLMS	LARGE_INTESTINE	274	p.P275fs	c.823_823delC	Frame_Shift_Del	6	0.11	RKO	N	1	0	0	N
NF2	KSVSDDSGN	LARGE_INTESTINE	174	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	1	0	0	N
NF2	LEWMPWGFT	STOMACH	234	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	7	0	0	N
NF2	LLLNHWIRK	LUNG	271	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	N	6	0	0	N
NF2	LLNHWIRKL	LUNG	272	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	Y	11	10	14	N
NF2	LNHWIRKLM	LUNG	273	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	N	4	0	11	N
NF2	LVRRAPRPS	LARGE_INTESTINE	190	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	28	N
NF2	LVTACLSTS	PLEURA	498	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	0	0	17	N
NF2	MNHRCLLTY	PLEURA	484	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	7	0	5	N
NF2	MPWGFTFMT	STOMACH	237	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	Y	9	9	0	N
NF2	NHWIRKLMS	LUNG	274	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	N	1	0	0	N
NF2	NKRAQSCCL	STOMACH	226	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	3	0	0	N
NF2	NVGGENYCL	LARGE_INTESTINE	182	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	6	0	0	N
NF2	NYCLVRRAP	LARGE_INTESTINE	187	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	PCSQAGIFG	LARGE_INTESTINE	155	p.P155fs	c.465_466delCA	Frame_Shift_Del	7	0.11	SNUC4	N	0	0	0	N
NF2	PMNHRCLLT	PLEURA	483	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	0	0	0	N
NF2	PWGFTFMTL	STOMACH	238	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	0	0	0	N
NF2	QAGIFGPRG	LARGE_INTESTINE	158	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	QASTSLVTA	PLEURA	493	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	3	0	0	N
NF2	QSCCLEWMP	STOMACH	230	p.K227fs	c.679_679delA	Frame_Shift_Del	7	0.11	NUGC3	N	0	0	0	N
NF2	RCLLTYQAS	PLEURA	487	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	1	0	0	N
NF2	RGMKSETSR	LUNG	257	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	N	0	0	0	N
NF2	RNKRAQSCC	STOMACH	225	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	0	0	0	N
NF2	RSLLLNHWI	LUNG	269	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	Y	9	13	0	N
NF2	SCCLEWMPW	STOMACH	231	p.K227fs	c.679_679delA	Frame_Shift_Del	7	0.11	NUGC3	N	2	0	0	N
NF2	SDDSGNVGG	LARGE_INTESTINE	177	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	0	0	0	N
NF2	SGNVGGENY	LARGE_INTESTINE	180	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	5	0	0	N
NF2	SKKGNKSVS	LARGE_INTESTINE	169	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	1	0	0	N
NF2	SLLLNHWIR	LUNG	270	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	Y	6	11	0	N
NF2	SQAGIFGPR	LARGE_INTESTINE	157	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	5	0	0	N
NF2	TRSLLLNHW	LUNG	268	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.11	LOUNH91	Y	2	9	0	N
NF2	VGGENYCLV	LARGE_INTESTINE	183	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	Y	10	11	0	N
NF2	VSDDSGNVG	LARGE_INTESTINE	176	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	1	0	0	N
NF2	WGFTFMTLR	STOMACH	239	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	N	4	0	2	N
NF2	WMPWGFTFM	STOMACH	236	p.K227fs	c.679_679delA	Frame_Shift_Del	6	0.11	NUGC3	Y	14	9	0	N
NF2	YCLVRRAPR	LARGE_INTESTINE	188	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	6	0	8	N
NF2	YDPCSQAGI	LARGE_INTESTINE	153	p.P155fs	c.465_466delCA	Frame_Shift_Del	6	0.11	SNUC4	N	7	0	0	N
NF2	YQASTSLVT	PLEURA	492	p.P486fs	c.1456_1465delCCAATTCCAG	Frame_Shift_Del	6	0.11	MPP89	N	6	0	5	N
NF2	HWIRKLMSS	LUNG	275	p.F256fs	c.768_768delC	Frame_Shift_Del	6	0.22	LOUNH91	N	0	0	0	N
NF2	HWIRKLMSS	LARGE_INTESTINE	275	p.P275fs	c.823_823delC	Frame_Shift_Del	6	0.22	RKO	N	0	0	0	N