Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
FBXW7	AVLEMPLLG	ENDOMETRIUM	476	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	N	0	0	0	N
FBXW7	EMPLLGFGI	ENDOMETRIUM	479	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	N	9	0	0	N
FBXW7	ILRQASVYM	ENDOMETRIUM	487	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	Y	7	10	17	N
FBXW7	LEMPLLGFG	ENDOMETRIUM	478	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	N	2	0	0	N
FBXW7	LRQASVYMF	ENDOMETRIUM	488	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	Y	5	10	27	N
FBXW7	MPLLGFGIL	ENDOMETRIUM	480	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	N	23	0	0	N
FBXW7	VLEMPLLGF	ENDOMETRIUM	477	p.R473fs	c.1417_1417delA	Frame_Shift_Del	6	0.11	HEC108	N	6	0	2	N
FBXW7	CWCWTLMWT	LARGE_INTESTINE	697	p.G667fs	c.2001_2001delG	Frame_Shift_Del	7	0.22	SNUC5	N	0	0	0	N
FBXW7	CWCWTLMWT	LARGE_INTESTINE	697	p.G667fs	c.2001_2001delG	Frame_Shift_Del	7	0.22	SW48	N	0	0	0	N
FBXW7	GLKKPSCWC	LARGE_INTESTINE	691	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	2	0	0	N
FBXW7	GLKKPSCWC	LARGE_INTESTINE	691	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	2	0	0	N
FBXW7	KKPSCWCWT	LARGE_INTESTINE	693	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	2	0	0	N
FBXW7	KKPSCWCWT	LARGE_INTESTINE	693	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	2	0	0	N
FBXW7	KPSCWCWTL	LARGE_INTESTINE	694	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	Y	19	9	0	N
FBXW7	KPSCWCWTL	LARGE_INTESTINE	694	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	Y	19	9	0	N
FBXW7	LKKPSCWCW	LARGE_INTESTINE	692	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	4	0	0	N
FBXW7	LKKPSCWCW	LARGE_INTESTINE	692	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	4	0	0	N
FBXW7	MGLKKPSCW	LARGE_INTESTINE	690	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	3	0	5	N
FBXW7	MGLKKPSCW	LARGE_INTESTINE	690	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	3	0	5	N
FBXW7	PQTQSWCVQ	LARGE_INTESTINE	677	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	0	0	0	N
FBXW7	PQTQSWCVQ	LARGE_INTESTINE	677	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	0	0	0	N
FBXW7	PSCWCWTLM	LARGE_INTESTINE	695	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	0	0	0	N
FBXW7	PSCWCWTLM	LARGE_INTESTINE	695	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	0	0	0	N
FBXW7	SCWCWTLMW	LARGE_INTESTINE	696	p.G667fs	c.2001_2001delG	Frame_Shift_Del	7	0.22	SNUC5	N	5	0	0	N
FBXW7	SCWCWTLMW	LARGE_INTESTINE	696	p.G667fs	c.2001_2001delG	Frame_Shift_Del	7	0.22	SW48	N	5	0	0	N
FBXW7	TQSWCVQLG	LARGE_INTESTINE	679	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	0	0	0	N
FBXW7	TQSWCVQLG	LARGE_INTESTINE	679	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	0	0	0	N
FBXW7	WCVQLGVGM	LARGE_INTESTINE	682	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SNUC5	N	7	0	1	N
FBXW7	WCVQLGVGM	LARGE_INTESTINE	682	p.G667fs	c.2001_2001delG	Frame_Shift_Del	6	0.22	SW48	N	7	0	1	N
FBXW7	ENISGTYRW	LARGE_INTESTINE	415	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	Y	2	17	0	N
FBXW7	GTYRWSMVI	LARGE_INTESTINE	419	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	13	0	0	N
FBXW7	ISGTYRWSM	LARGE_INTESTINE	417	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	5	0	0	N
FBXW7	ITNERQHHH	LARGE_INTESTINE	427	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	Y	0	10	0	N
FBXW7	LVSSHRQMS	LARGE_INTESTINE	406	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	0	0	25	N
FBXW7	MVITNERQH	LARGE_INTESTINE	425	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	2	0	9	N
FBXW7	NISGTYRWS	LARGE_INTESTINE	416	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	1	0	0	N
FBXW7	NTFKSLVSS	LARGE_INTESTINE	401	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	1	0	0	N
FBXW7	RWSMVITNE	LARGE_INTESTINE	422	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	0	0	0	N
FBXW7	SMVITNERQ	LARGE_INTESTINE	424	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	0	0	0	N
FBXW7	TFKSLVSSH	LARGE_INTESTINE	402	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	0	0	0	N
FBXW7	TYRWSMVIT	LARGE_INTESTINE	420	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	Y	1	11	0	N
FBXW7	VITNERQHH	LARGE_INTESTINE	426	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	0	0	9	N
FBXW7	VSSHRQMSE	LARGE_INTESTINE	407	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	0	0	0	N
FBXW7	WSMVITNER	LARGE_INTESTINE	423	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	5	0	10	N
FBXW7	YRWSMVITN	LARGE_INTESTINE	421	p.L403fs	c.1208_1209insT	Frame_Shift_Ins	6	0.11	SW837	N	5	0	15	N