Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
RET	AGLPPREPQ	LUNG	813	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	Y
RET	APPHRGVRQ	LUNG	800	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	Y
RET	APPPSSPPF	LARGE_INTESTINE	1046	p.A1046fs	c.3136_3137insC	Frame_Shift_Ins	5	0.11	LS411N	N	13	0	0	N
RET	AWLPGQWRQ	LUNG	824	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	DGPAPPHRG	LUNG	797	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	1	0	0	Y
RET	EPQSGAWLP	LUNG	819	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	1	0	0	N
RET	GAWLPGQWR	LUNG	823	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	7	0	0	N
RET	GLPPREPQS	LUNG	814	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	1	0	0	Y
RET	GPAPPHRGV	LUNG	798	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	13	12	0	Y
RET	GQWRQPQLQ	LUNG	828	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	GVRQIRLPA	LUNG	805	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	2	0	0	N
RET	HRGVRQIRL	LUNG	803	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	7	10	0	N
RET	IRLPAGLPP	LUNG	809	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	1	0	2	N
RET	LPAGLPPRE	LUNG	811	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	1	0	0	N
RET	LPGQWRQPQ	LUNG	826	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	2	0	0	N
RET	LPPREPQSG	LUNG	815	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	1	0	0	Y
RET	PAGLPPREP	LUNG	812	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	PAPPHRGVR	LUNG	799	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	Y
RET	PGQWRQPQL	LUNG	827	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	1	0	0	N
RET	PHRGVRQIR	LUNG	802	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	N
RET	PPHRGVRQI	LUNG	801	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	7	13	0	N
RET	PPPSSPPFH	LARGE_INTESTINE	1047	p.A1046fs	c.3136_3137insC	Frame_Shift_Ins	5	0.11	LS411N	N	0	0	0	N
RET	PPREPQSGA	LUNG	816	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	4	0	0	Y
RET	PPSSPPFHM	LARGE_INTESTINE	1048	p.A1046fs	c.3136_3137insC	Frame_Shift_Ins	6	0.11	LS411N	N	5	0	0	N
RET	PQLQLPGPP	LUNG	833	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	PQSGAWLPG	LUNG	820	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	PREPQSGAW	LUNG	817	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	1	0	0	N
RET	PSSPPFHMD	LARGE_INTESTINE	1049	p.A1046fs	c.3136_3137insC	Frame_Shift_Ins	5	0.11	LS411N	N	0	0	0	N
RET	QDGPAPPHR	LUNG	796	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	Y
RET	QIRLPAGLP	LUNG	808	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	QLQLPGPPG	LUNG	834	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	N
RET	QPQLQLPGP	LUNG	832	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	QSGAWLPGQ	LUNG	821	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	0	0	0	N
RET	REPQSGAWL	LUNG	818	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	Y	12	10	0	N
RET	RGVRQIRLP	LUNG	804	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	0	0	0	N
RET	RLPAGLPPR	LUNG	810	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	7	0	0	N
RET	RQIRLPAGL	LUNG	807	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	16	0	0	N
RET	SGAWLPGQW	LUNG	822	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	2	0	0	N
RET	VRQIRLPAG	LUNG	806	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	6	0.11	NCIH2347	N	1	0	10	N
RET	WLPGQWRQP	LUNG	825	p.G798fs	c.2393_2394insC	Frame_Shift_Ins	5	0.11	NCIH2347	N	2	0	0	N