Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
PTEN	AELAILSLW	CENTRAL_NERVOUS_SYSTEM	208	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	7	0	0	N
PTEN	AILSLWSAS	CENTRAL_NERVOUS_SYSTEM	211	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	AQYPLKTIT	BREAST	86	p.P89fs	c.267_267delT	Frame_Shift_Del	5	0.11	HCC70	N	5	0	0	N
PTEN	AYLLHRANF	OVARY	137	p.R142fs	c.425_425delG	Frame_Shift_Del	2	0.11	TOV21G	Y	5	9	0	N
PTEN	CAYLLHRAN	OVARY	136	p.R142fs	c.425_425delG	Frame_Shift_Del	2	0.11	TOV21G	N	3	0	0	N
PTEN	CKAGKGQLV	ENDOMETRIUM	124	p.R130fs	c.389_389delG	Frame_Shift_Del	3	0.11	AN3CA	N	2	0	0	N
PTEN	CRVAQYPLK	BREAST	83	p.P89fs	c.267_267delT	Frame_Shift_Del	2	0.11	HCC70	N	2	0	0	N
PTEN	CSVAELAIL	CENTRAL_NERVOUS_SYSTEM	205	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	Y	13	11	0	N
PTEN	ELAILSLWS	CENTRAL_NERVOUS_SYSTEM	209	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	ELIKPFVKI	LARGE_INTESTINE	99	p.F104fs	c.310_310delT	Frame_Shift_Del	3	0.11	LS411N	N	11	0	0	N
PTEN	ETIQCSVAE	CENTRAL_NERVOUS_SYSTEM	201	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	0	0	0	N
PTEN	FEFPHTCVW	LUNG	241	p.Q245fs	c.735_739delGCCGT	Frame_Shift_Del	5	0.11	NCIH1781	N	9	0	0	N
PTEN	FETIQCSVA	CENTRAL_NERVOUS_SYSTEM	200	p.P204fs	c.610_610delC	Frame_Shift_Del	5	0.11	M059K	N	8	0	2	N
PTEN	FHFWVNTLY	BREAST	271	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	2	0.11	CAMA1	N	6	0	3	N
PTEN	FIPGPEETQ	CENTRAL_NERVOUS_SYSTEM	279	p.T286fs	c.857_857delC	Frame_Shift_Del	1	0.11	CAS1	N	2	0	0	N
PTEN	FMYFEFPHT	LUNG	238	p.Q245fs	c.735_739delGCCGT	Frame_Shift_Del	2	0.11	NCIH1781	N	9	0	2	N
PTEN	FWVNTLYQD	BREAST	273	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	4	0.11	CAMA1	N	2	0	0	N
PTEN	HCKAGKGQL	ENDOMETRIUM	123	p.R130fs	c.389_389delG	Frame_Shift_Del	2	0.11	AN3CA	N	5	0	0	N
PTEN	HFWVNTLYQ	BREAST	272	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	3	0.11	CAMA1	N	0	0	0	N
PTEN	HKMMFETIQ	CENTRAL_NERVOUS_SYSTEM	196	p.P204fs	c.610_610delC	Frame_Shift_Del	1	0.11	M059K	N	0	0	0	N
PTEN	ICAYLLHRA	OVARY	135	p.R142fs	c.425_425delG	Frame_Shift_Del	1	0.11	TOV21G	N	1	0	2	N
PTEN	IKPFVKILT	LARGE_INTESTINE	101	p.F104fs	c.310_310delT	Frame_Shift_Del	4	0.11	LS411N	N	1	0	14	N
PTEN	IKTKPTDTF	ENDOMETRIUM	329	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	4	0	0	N
PTEN	ILTKQIKTK	ENDOMETRIUM	324	p.T321fs	c.963_963delA	Frame_Shift_Del	5	0.11	MFE296	N	3	0	5	N
PTEN	IPGPEETQK	CENTRAL_NERVOUS_SYSTEM	280	p.T286fs	c.857_857delC	Frame_Shift_Del	2	0.11	CAS1	N	3	0	0	N
PTEN	IQCSVAELA	CENTRAL_NERVOUS_SYSTEM	203	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	4	0	4	N
PTEN	KFMYFEFPH	LUNG	237	p.Q245fs	c.735_739delGCCGT	Frame_Shift_Del	1	0.11	NCIH1781	N	0	0	0	N
PTEN	KMILTKQIK	ENDOMETRIUM	322	p.T321fs	c.963_963delA	Frame_Shift_Del	5	0.11	MFE296	N	6	0	0	N
PTEN	KMMFETIQC	CENTRAL_NERVOUS_SYSTEM	197	p.P204fs	c.610_610delC	Frame_Shift_Del	2	0.11	M059K	N	4	0	0	N
PTEN	KPFVKILTN	LARGE_INTESTINE	102	p.F104fs	c.310_310delT	Frame_Shift_Del	5	0.11	LS411N	N	6	0	0	N
PTEN	KPTDTFLQI	ENDOMETRIUM	332	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	Y	14	10	0	N
PTEN	KQIKTKPTD	ENDOMETRIUM	327	p.T321fs	c.963_963delA	Frame_Shift_Del	5	0.11	MFE296	N	0	0	0	N
PTEN	KTKPTDTFL	ENDOMETRIUM	330	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	11	0	0	N
PTEN	LAILSLWSA	CENTRAL_NERVOUS_SYSTEM	210	p.P204fs	c.610_610delC	Frame_Shift_Del	6	0.11	M059K	N	7	0	10	N
PTEN	LELIKPFVK	LARGE_INTESTINE	98	p.F104fs	c.310_310delT	Frame_Shift_Del	2	0.11	LS411N	N	3	0	5	N
PTEN	LIKPFVKIL	LARGE_INTESTINE	100	p.F104fs	c.310_310delT	Frame_Shift_Del	3	0.11	LS411N	Y	10	9	0	N
PTEN	LTKMILTKQ	ENDOMETRIUM	320	p.T321fs	c.963_963delA	Frame_Shift_Del	4	0.11	MFE296	N	0	0	0	N
PTEN	LTKQIKTKP	ENDOMETRIUM	325	p.T321fs	c.963_963delA	Frame_Shift_Del	5	0.11	MFE296	N	0	0	0	N
PTEN	LTLTKMILT	ENDOMETRIUM	318	p.T321fs	c.963_963delA	Frame_Shift_Del	3	0.11	MFE296	N	1	0	0	N
PTEN	LVLTLTKMI	ENDOMETRIUM	316	p.T321fs	c.963_963delA	Frame_Shift_Del	2	0.11	MFE296	N	13	0	38	N
PTEN	LYQDQRKPQ	BREAST	278	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	6	0.11	CAMA1	N	0	0	7	N
PTEN	MFETIQCSV	CENTRAL_NERVOUS_SYSTEM	199	p.P204fs	c.610_610delC	Frame_Shift_Del	4	0.11	M059K	N	4	0	0	N
PTEN	MFHFWVNTL	BREAST	270	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	1	0.11	CAMA1	Y	9	9	18	N
PTEN	MILTKQIKT	ENDOMETRIUM	323	p.T321fs	c.963_963delA	Frame_Shift_Del	6	0.11	MFE296	N	2	0	2	N
PTEN	MMFETIQCS	CENTRAL_NERVOUS_SYSTEM	198	p.P204fs	c.610_610delC	Frame_Shift_Del	3	0.11	M059K	N	4	0	11	N
PTEN	MYFEFPHTC	LUNG	239	p.Q245fs	c.735_739delGCCGT	Frame_Shift_Del	3	0.11	NCIH1781	N	1	0	4	N
PTEN	NCRVAQYPL	BREAST	82	p.P89fs	c.267_267delT	Frame_Shift_Del	1	0.11	HCC70	N	5	0	0	N
PTEN	NTLYQDQRK	BREAST	276	p.F278fs	c.834_837delCTTC	Frame_Shift_Del	6	0.11	CAMA1	N	3	0	0	N
PTEN	PFVKILTNG	LARGE_INTESTINE	103	p.F104fs	c.310_310delT	Frame_Shift_Del	6	0.11	LS411N	N	0	0	0	N
PTEN	PGPEETQKK	CENTRAL_NERVOUS_SYSTEM	281	p.T286fs	c.857_857delC	Frame_Shift_Del	2	0.11	CAS1	N	0	0	0	N