Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MSH3	DVKSLTVCH	UPPER_AERODIGESTIVE_TRACT	1000	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	3	0.11	CAL33	N	2	0	0	N
MSH3	IRDVKSLTV	UPPER_AERODIGESTIVE_TRACT	998	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	1	0.11	CAL33	N	6	0	10	N
MSH3	KSLTVCHPL	UPPER_AERODIGESTIVE_TRACT	1002	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	5	0.11	CAL33	N	17	0	0	N
MSH3	LTVCHPLSA	UPPER_AERODIGESTIVE_TRACT	1004	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	6	0.11	CAL33	N	4	0	4	N
MSH3	RDVKSLTVC	UPPER_AERODIGESTIVE_TRACT	999	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	2	0.11	CAL33	N	4	0	0	N
MSH3	SLTVCHPLS	UPPER_AERODIGESTIVE_TRACT	1003	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	6	0.11	CAL33	N	0	0	0	N
MSH3	TVCHPLSAS	UPPER_AERODIGESTIVE_TRACT	1005	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	6	0.11	CAL33	N	0	0	0	N
MSH3	VCHPLSASL	UPPER_AERODIGESTIVE_TRACT	1006	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	6	0.11	CAL33	N	10	0	0	N
MSH3	VKSLTVCHP	UPPER_AERODIGESTIVE_TRACT	1001	p.L1006fs	c.3016_3017delCT	Frame_Shift_Del	4	0.11	CAL33	N	0	0	13	N
MSH3	ALWECSLPQ	PROSTATE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	22RV1	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	CL34	N	0	0	0	N
MSH3	ALWECSLPQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	DND41	N	0	0	0	N
MSH3	ALWECSLPQ	PROSTATE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	DU145	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	GP2D	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	HCT116	N	0	0	0	N
MSH3	ALWECSLPQ	ENDOMETRIUM	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	HEC151	N	0	0	0	N
MSH3	ALWECSLPQ	ENDOMETRIUM	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	HEC265	N	0	0	0	N
MSH3	ALWECSLPQ	ENDOMETRIUM	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	HEC59	N	0	0	0	N
MSH3	ALWECSLPQ	OVARY	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	IGROV1	N	0	0	0	N
MSH3	ALWECSLPQ	STOMACH	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	IM95	N	0	0	0	N
MSH3	ALWECSLPQ	ENDOMETRIUM	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	JHUEM1	N	0	0	0	N
MSH3	ALWECSLPQ	PROSTATE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	LNCAPCLONEFGC	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	LS411N	N	0	0	0	N
MSH3	ALWECSLPQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	NALM6	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	RKO	N	0	0	0	N
MSH3	ALWECSLPQ	ENDOMETRIUM	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	RL952	N	0	0	0	N
MSH3	ALWECSLPQ	ENDOMETRIUM	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	SNGM	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	SNU1040	N	0	0	0	N
MSH3	ALWECSLPQ	STOMACH	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	SNU1	N	0	0	0	N
MSH3	ALWECSLPQ	PANCREAS	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	SNU324	N	0	0	0	N
MSH3	ALWECSLPQ	STOMACH	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	SNU520	N	0	0	0	N
MSH3	ALWECSLPQ	LARGE_INTESTINE	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	SNUC4	N	0	0	0	N
MSH3	ALWECSLPQ	STOMACH	389	p.K381fs	c.1141_1141delA	Frame_Shift_Del	6	2.65	TGBC11TKB	N	0	0	0	N
MSH3	ARLCLIVSR	PROSTATE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	22RV1	Y	3	9	0	N
MSH3	ARLCLIVSR	LARGE_INTESTINE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	CL34	Y	3	9	0	N
MSH3	ARLCLIVSR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	DND41	Y	3	9	0	N
MSH3	ARLCLIVSR	PROSTATE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	DU145	Y	3	9	0	N
MSH3	ARLCLIVSR	LARGE_INTESTINE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	GP2D	Y	3	9	0	N
MSH3	ARLCLIVSR	LARGE_INTESTINE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	HCT116	Y	3	9	0	N
MSH3	ARLCLIVSR	ENDOMETRIUM	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	HEC151	Y	3	9	0	N
MSH3	ARLCLIVSR	ENDOMETRIUM	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	HEC265	Y	3	9	0	N
MSH3	ARLCLIVSR	ENDOMETRIUM	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	HEC59	Y	3	9	0	N
MSH3	ARLCLIVSR	OVARY	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	IGROV1	Y	3	9	0	N
MSH3	ARLCLIVSR	STOMACH	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	IM95	Y	3	9	0	N
MSH3	ARLCLIVSR	ENDOMETRIUM	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	JHUEM1	Y	3	9	0	N
MSH3	ARLCLIVSR	PROSTATE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	LNCAPCLONEFGC	Y	3	9	0	N
MSH3	ARLCLIVSR	LARGE_INTESTINE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	LS411N	Y	3	9	0	N
MSH3	ARLCLIVSR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	NALM6	Y	3	9	0	N
MSH3	ARLCLIVSR	LARGE_INTESTINE	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	RKO	Y	3	9	0	N
MSH3	ARLCLIVSR	ENDOMETRIUM	398	p.K381fs	c.1141_1141delA	Frame_Shift_Del	5	2.65	RL952	Y	3	9	0	N