Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MAP3K4	ALAVAMLSF	ENDOMETRIUM	190	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	5	0	0	N
MAP3K4	AMLSFQYLC	ENDOMETRIUM	194	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	Y	4	9	0	N
MAP3K4	ATQGLIFYK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1092	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	4	0.11	MOLP2	Y	5	11	0	N
MAP3K4	AVAMLSFQY	ENDOMETRIUM	192	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	N	6	0	0	N
MAP3K4	DPRVPESDS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	468	p.E473fs	c.1418_1418delA	Frame_Shift_Del	3	0.11	JEKO1	N	5	0	0	N
MAP3K4	FQLYQKMTS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1107	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	2	0	36	N
MAP3K4	FQMWISISL	ENDOMETRIUM	179	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	Y	18	10	25	N
MAP3K4	FYKQLNLPL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1098	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	Y	9	10	9	N
MAP3K4	GGSLPKNQF	ENDOMETRIUM	171	p.P175fs	c.525_525delA	Frame_Shift_Del	3	0.11	MFE296	N	2	0	0	Y
MAP3K4	GLIFYKQLN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1095	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	1	0	0	N
MAP3K4	GSLPKNQFQ	ENDOMETRIUM	172	p.P175fs	c.525_525delA	Frame_Shift_Del	4	0.11	MFE296	N	0	0	0	N
MAP3K4	IFYKQLNLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1097	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	0	0	1	N
MAP3K4	ISISLTSAL	ENDOMETRIUM	183	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	17	0	8	N
MAP3K4	ISLTSALAV	ENDOMETRIUM	185	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	6	0	2	N
MAP3K4	KNQFQMWIS	ENDOMETRIUM	176	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	N	0	0	0	N
MAP3K4	KQLNLPLFQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1100	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	0	0	0	N
MAP3K4	LAVAMLSFQ	ENDOMETRIUM	191	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	0	0	0	N
MAP3K4	LFQLYQKMT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1106	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	1	0	0	N
MAP3K4	LIFYKQLNL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1096	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	15	0	11	N
MAP3K4	LNLPLFQLY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1102	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	9	0	0	N
MAP3K4	LPKNQFQMW	ENDOMETRIUM	174	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	N	7	0	0	N
MAP3K4	LPLFQLYQK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1104	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	6	0	0	N
MAP3K4	LSFQYLCPC	ENDOMETRIUM	196	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	1	0	0	N
MAP3K4	LTSALAVAM	ENDOMETRIUM	187	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	4	0	1	N
MAP3K4	MLSFQYLCP	ENDOMETRIUM	195	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	0	0	3	N
MAP3K4	MWISISLTS	ENDOMETRIUM	181	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	0	0	28	N
MAP3K4	NLPLFQLYQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1103	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	1	0	0	N
MAP3K4	NQFQMWISI	ENDOMETRIUM	177	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	Y	13	12	0	N
MAP3K4	PKNQFQMWI	ENDOMETRIUM	175	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	N	5	0	0	N
MAP3K4	PLFQLYQKM	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1105	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	3	0	0	N
MAP3K4	PRVPESDSP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	469	p.E473fs	c.1418_1418delA	Frame_Shift_Del	3	0.11	JEKO1	N	0	0	0	N
MAP3K4	QFQMWISIS	ENDOMETRIUM	178	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	N	0	0	0	N
MAP3K4	QGLIFYKQL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1094	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	15	0	0	N
MAP3K4	QLNLPLFQL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1101	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	Y	10	11	0	N
MAP3K4	QMWISISLT	ENDOMETRIUM	180	p.P175fs	c.525_525delA	Frame_Shift_Del	6	0.11	MFE296	N	5	0	0	N
MAP3K4	SALAVAMLS	ENDOMETRIUM	189	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	2	0	0	N
MAP3K4	SFQYLCPCL	ENDOMETRIUM	197	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	8	0	0	N
MAP3K4	SISLTSALA	ENDOMETRIUM	184	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	0	0	0	N
MAP3K4	SLPKNQFQM	ENDOMETRIUM	173	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	Y	10	9	0	Y
MAP3K4	SLTSALAVA	ENDOMETRIUM	186	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	3	0	0	N
MAP3K4	TQGLIFYKQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1093	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	0	0	0	N
MAP3K4	TSALAVAML	ENDOMETRIUM	188	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	Y	9	10	0	N
MAP3K4	VAMLSFQYL	ENDOMETRIUM	193	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	18	0	1	N
MAP3K4	WATQGLIFY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1091	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	3	0.11	MOLP2	Y	9	11	0	N
MAP3K4	WISISLTSA	ENDOMETRIUM	182	p.P175fs	c.525_525delA	Frame_Shift_Del	5	0.11	MFE296	N	5	0	4	N
MAP3K4	YHKEVVWGV	STOMACH	1046	p.V1050fs	c.3150_3160delTGTTCGTTTGA	Frame_Shift_Del	3	0.11	SNU601	Y	5	13	0	N
MAP3K4	YKQLNLPLF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1099	p.F1096fs	c.3286_3286delT	Frame_Shift_Del	5	0.11	MOLP2	N	5	0	7	N
MAP3K4	DHKKMYSAH	ENDOMETRIUM	156	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	AN3CA	N	0	0	0	N
MAP3K4	DHKKMYSAH	LARGE_INTESTINE	156	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	CW2	N	0	0	0	N
MAP3K4	DHKKMYSAH	ENDOMETRIUM	156	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	HEC151	N	0	0	0	N
MAP3K4	DHKKMYSAH	ENDOMETRIUM	156	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	HEC265	N	0	0	0	N
MAP3K4	DHKKMYSAH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	156	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	P31FUJ	N	0	0	0	N
MAP3K4	DHKKMYSAH	LARGE_INTESTINE	156	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	SNUC4	N	0	0	0	N
MAP3K4	ERDHKKMYS	ENDOMETRIUM	154	p.K158fs	c.472_472delA	Frame_Shift_Del	3	0.66	AN3CA	N	1	0	0	Y
MAP3K4	ERDHKKMYS	LARGE_INTESTINE	154	p.K158fs	c.472_472delA	Frame_Shift_Del	3	0.66	CW2	N	1	0	0	Y
MAP3K4	ERDHKKMYS	ENDOMETRIUM	154	p.K158fs	c.472_472delA	Frame_Shift_Del	3	0.66	HEC151	N	1	0	0	Y
MAP3K4	ERDHKKMYS	ENDOMETRIUM	154	p.K158fs	c.472_472delA	Frame_Shift_Del	3	0.66	HEC265	N	1	0	0	Y
MAP3K4	ERDHKKMYS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	154	p.K158fs	c.472_472delA	Frame_Shift_Del	3	0.66	P31FUJ	N	1	0	0	Y
MAP3K4	ERDHKKMYS	LARGE_INTESTINE	154	p.K158fs	c.472_472delA	Frame_Shift_Del	3	0.66	SNUC4	N	1	0	0	Y
MAP3K4	HKKMYSAHS	ENDOMETRIUM	157	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	AN3CA	N	1	0	0	N
MAP3K4	HKKMYSAHS	LARGE_INTESTINE	157	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	CW2	N	1	0	0	N
MAP3K4	HKKMYSAHS	ENDOMETRIUM	157	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	HEC151	N	1	0	0	N
MAP3K4	HKKMYSAHS	ENDOMETRIUM	157	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	HEC265	N	1	0	0	N
MAP3K4	HKKMYSAHS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	157	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	P31FUJ	N	1	0	0	N
MAP3K4	HKKMYSAHS	LARGE_INTESTINE	157	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	SNUC4	N	1	0	0	N
MAP3K4	KKMYSAHSC	ENDOMETRIUM	158	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	AN3CA	N	1	0	0	N
MAP3K4	KKMYSAHSC	LARGE_INTESTINE	158	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	CW2	N	1	0	0	N
MAP3K4	KKMYSAHSC	ENDOMETRIUM	158	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	HEC151	N	1	0	0	N
MAP3K4	KKMYSAHSC	ENDOMETRIUM	158	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	HEC265	N	1	0	0	N
MAP3K4	KKMYSAHSC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	158	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	P31FUJ	N	1	0	0	N
MAP3K4	KKMYSAHSC	LARGE_INTESTINE	158	p.K158fs	c.472_472delA	Frame_Shift_Del	5	0.66	SNUC4	N	1	0	0	N
MAP3K4	RDHKKMYSA	ENDOMETRIUM	155	p.K158fs	c.472_472delA	Frame_Shift_Del	4	0.66	AN3CA	N	4	0	0	N
MAP3K4	RDHKKMYSA	LARGE_INTESTINE	155	p.K158fs	c.472_472delA	Frame_Shift_Del	4	0.66	CW2	N	4	0	0	N
MAP3K4	RDHKKMYSA	ENDOMETRIUM	155	p.K158fs	c.472_472delA	Frame_Shift_Del	4	0.66	HEC151	N	4	0	0	N
MAP3K4	RDHKKMYSA	ENDOMETRIUM	155	p.K158fs	c.472_472delA	Frame_Shift_Del	4	0.66	HEC265	N	4	0	0	N
MAP3K4	RDHKKMYSA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	155	p.K158fs	c.472_472delA	Frame_Shift_Del	4	0.66	P31FUJ	N	4	0	0	N
MAP3K4	RDHKKMYSA	LARGE_INTESTINE	155	p.K158fs	c.472_472delA	Frame_Shift_Del	4	0.66	SNUC4	N	4	0	0	N
MAP3K4	AKKINSRCG	ENDOMETRIUM	175	p.H157fs	c.471_472insA	Frame_Shift_Ins	6	0.11	MFE319	N	0	0	0	N
MAP3K4	CTVLIHVRL	ENDOMETRIUM	161	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	10	0	0	N
MAP3K4	DHKKKCTVL	ENDOMETRIUM	156	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	5	0	0	N
MAP3K4	ERDHKKKCT	ENDOMETRIUM	154	p.H157fs	c.471_472insA	Frame_Shift_Ins	3	0.11	MFE319	N	1	0	0	Y
MAP3K4	FAKKINSRC	ENDOMETRIUM	174	p.H157fs	c.471_472insA	Frame_Shift_Ins	6	0.11	MFE319	N	7	0	1	N
MAP3K4	GWIFAKKIN	ENDOMETRIUM	171	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	0	0	0	N
MAP3K4	HKKKCTVLI	ENDOMETRIUM	157	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	3	0	0	N
MAP3K4	HVRLSGWIF	ENDOMETRIUM	166	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	Y	4	9	0	N
MAP3K4	IFAKKINSR	ENDOMETRIUM	173	p.H157fs	c.471_472insA	Frame_Shift_Ins	6	0.11	MFE319	N	2	0	4	N
MAP3K4	IHVRLSGWI	ENDOMETRIUM	165	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	6	0	4	N
MAP3K4	KCTVLIHVR	ENDOMETRIUM	160	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	3	0	0	N
MAP3K4	KINSRCGSQ	ENDOMETRIUM	177	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	0	0	0	N
MAP3K4	KKCTVLIHV	ENDOMETRIUM	159	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	4	0	0	N
MAP3K4	KKINSRCGS	ENDOMETRIUM	176	p.H157fs	c.471_472insA	Frame_Shift_Ins	6	0.11	MFE319	N	1	0	0	N
MAP3K4	KKKCTVLIH	ENDOMETRIUM	158	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	2	0	0	N
MAP3K4	LIHVRLSGW	ENDOMETRIUM	164	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	3	0	0	N
MAP3K4	LSGWIFAKK	ENDOMETRIUM	169	p.H157fs	c.471_472insA	Frame_Shift_Ins	6	0.11	MFE319	N	3	0	0	N
MAP3K4	RDHKKKCTV	ENDOMETRIUM	155	p.H157fs	c.471_472insA	Frame_Shift_Ins	4	0.11	MFE319	Y	4	11	0	Y
MAP3K4	RLSGWIFAK	ENDOMETRIUM	168	p.H157fs	c.471_472insA	Frame_Shift_Ins	6	0.11	MFE319	Y	6	14	0	N
MAP3K4	SGWIFAKKI	ENDOMETRIUM	170	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	8	0	0	N
MAP3K4	TVLIHVRLS	ENDOMETRIUM	162	p.H157fs	c.471_472insA	Frame_Shift_Ins	4	0.11	MFE319	N	0	0	0	N
MAP3K4	VLIHVRLSG	ENDOMETRIUM	163	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	0	0	32	N
MAP3K4	VRLSGWIFA	ENDOMETRIUM	167	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	Y	5	9	13	N
MAP3K4	WIFAKKINS	ENDOMETRIUM	172	p.H157fs	c.471_472insA	Frame_Shift_Ins	5	0.11	MFE319	N	2	0	34	N