Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MAP3K1	AAAPAGLRW	BREAST	156	p.R162fs	c.485_485delG	Frame_Shift_Del	3	0.11	MDAMB415	Y	3	12	0	N
MAP3K1	AAPAGLRWR	BREAST	157	p.R162fs	c.485_485delG	Frame_Shift_Del	4	0.11	MDAMB415	N	3	0	0	N
MAP3K1	AGLRWRIKK	BREAST	160	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	0	11	0	N
MAP3K1	APAGLRWRI	BREAST	158	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	13	14	0	N
MAP3K1	CTRWMIVQR	BREAST	173	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	Y	5	10	0	N
MAP3K1	GCTRWMIVQ	BREAST	172	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	0	0	0	N
MAP3K1	GLRWRIKKL	BREAST	161	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	11	12	0	N
MAP3K1	IKKLSKGCT	BREAST	166	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	1	N
MAP3K1	KGCTRWMIV	BREAST	171	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	7	0	0	N
MAP3K1	KKLSKGCTR	BREAST	167	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	0	Y
MAP3K1	KLSKGCTRW	BREAST	168	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	5	11	0	N
MAP3K1	LRWRIKKLS	BREAST	162	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	2	0	30	N
MAP3K1	LSKGCTRWM	BREAST	169	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	3	0	1	N
MAP3K1	PAAAPAGLR	BREAST	155	p.R162fs	c.485_485delG	Frame_Shift_Del	2	0.11	MDAMB415	N	0	0	0	N
MAP3K1	PAGLRWRIK	BREAST	159	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	0	0	0	N
MAP3K1	RIKKLSKGC	BREAST	165	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	0	N
MAP3K1	RWMIVQRNE	BREAST	175	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	0	0	0	N
MAP3K1	RWRIKKLSK	BREAST	163	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	0	N
MAP3K1	SKGCTRWMI	BREAST	170	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	Y	2	13	0	N
MAP3K1	SPAAAPAGL	BREAST	154	p.R162fs	c.485_485delG	Frame_Shift_Del	1	0.11	MDAMB415	N	15	0	0	N
MAP3K1	TRWMIVQRN	BREAST	174	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	2	0	0	N
MAP3K1	WRIKKLSKG	BREAST	164	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	3	0	24	N
MAP3K1	KQGDPSKIA	ENDOMETRIUM	1072	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	2	0.22	HEC1A	N	5	0	0	N
MAP3K1	KQGDPSKIA	ENDOMETRIUM	1072	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	2	0.22	HEC1B	N	5	0	0	N
MAP3K1	SKQGDPSKI	ENDOMETRIUM	1071	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	1	0.22	HEC1A	N	1	0	0	N
MAP3K1	SKQGDPSKI	ENDOMETRIUM	1071	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	1	0.22	HEC1B	N	1	0	0	N
MAP3K1	ALSPSSSTP	LIVER	982	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	ALEXANDERCELLS	N	0	0	0	N
MAP3K1	ALSPSSSTP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	982	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	MM1S	N	0	0	0	N
MAP3K1	ALSPSSSTP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	982	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	MOLT16	N	0	0	0	N
MAP3K1	ALSPSSSTP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	982	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	NALM1	N	0	0	0	N
MAP3K1	FPALSPSSS	LIVER	980	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	ALEXANDERCELLS	N	7	0	2	N
MAP3K1	FPALSPSSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	980	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MM1S	N	7	0	2	N
MAP3K1	FPALSPSSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	980	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MOLT16	N	7	0	2	N
MAP3K1	FPALSPSSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	980	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	NALM1	N	7	0	2	N
MAP3K1	LMFPALSPS	LIVER	978	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	ALEXANDERCELLS	N	3	0	0	N
MAP3K1	LMFPALSPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	978	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MM1S	N	3	0	0	N
MAP3K1	LMFPALSPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	978	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MOLT16	N	3	0	0	N
MAP3K1	LMFPALSPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	978	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	NALM1	N	3	0	0	N
MAP3K1	LSPSSSTPS	LIVER	983	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	ALEXANDERCELLS	N	0	0	0	N
MAP3K1	LSPSSSTPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	983	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MM1S	N	0	0	0	N
MAP3K1	LSPSSSTPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	983	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MOLT16	N	0	0	0	N
MAP3K1	LSPSSSTPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	983	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	NALM1	N	0	0	0	N
MAP3K1	MFPALSPSS	LIVER	979	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	ALEXANDERCELLS	N	0	0	4	N
MAP3K1	MFPALSPSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	979	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MM1S	N	0	0	4	N
MAP3K1	MFPALSPSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	979	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	MOLT16	N	0	0	4	N
MAP3K1	MFPALSPSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	979	p.T985del	c.2953_2955delACC	In_Frame_Del	2	0.44	NALM1	N	0	0	4	N
MAP3K1	PALSPSSST	LIVER	981	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	ALEXANDERCELLS	N	0	0	0	N
MAP3K1	PALSPSSST	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	981	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	MM1S	N	0	0	0	N
MAP3K1	PALSPSSST	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	981	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	MOLT16	N	0	0	0	N
MAP3K1	PALSPSSST	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	981	p.T985del	c.2953_2955delACC	In_Frame_Del	3	0.44	NALM1	N	0	0	0	N