Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
MAP3K1	AAAPAGLRW	BREAST	156	p.R162fs	c.485_485delG	Frame_Shift_Del	3	0.11	MDAMB415	Y	3	12	0	N
MAP3K1	AAPAGLRWR	BREAST	157	p.R162fs	c.485_485delG	Frame_Shift_Del	4	0.11	MDAMB415	N	3	0	0	N
MAP3K1	AGLRWRIKK	BREAST	160	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	0	11	0	N
MAP3K1	APAGLRWRI	BREAST	158	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	13	14	0	N
MAP3K1	CTRWMIVQR	BREAST	173	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	Y	5	10	0	N
MAP3K1	GCTRWMIVQ	BREAST	172	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	0	0	0	N
MAP3K1	GLRWRIKKL	BREAST	161	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	11	12	0	N
MAP3K1	IKKLSKGCT	BREAST	166	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	1	N
MAP3K1	KGCTRWMIV	BREAST	171	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	7	0	0	N
MAP3K1	KKLSKGCTR	BREAST	167	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	0	Y
MAP3K1	KLSKGCTRW	BREAST	168	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	Y	5	11	0	N
MAP3K1	LRWRIKKLS	BREAST	162	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	2	0	30	N
MAP3K1	LSKGCTRWM	BREAST	169	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	3	0	1	N
MAP3K1	PAAAPAGLR	BREAST	155	p.R162fs	c.485_485delG	Frame_Shift_Del	2	0.11	MDAMB415	N	0	0	0	N
MAP3K1	PAGLRWRIK	BREAST	159	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	0	0	0	N
MAP3K1	RIKKLSKGC	BREAST	165	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	0	N
MAP3K1	RWMIVQRNE	BREAST	175	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	0	0	0	N
MAP3K1	RWRIKKLSK	BREAST	163	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	1	0	0	N
MAP3K1	SKGCTRWMI	BREAST	170	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	Y	2	13	0	N
MAP3K1	SPAAAPAGL	BREAST	154	p.R162fs	c.485_485delG	Frame_Shift_Del	1	0.11	MDAMB415	N	15	0	0	N
MAP3K1	TRWMIVQRN	BREAST	174	p.R162fs	c.485_485delG	Frame_Shift_Del	6	0.11	MDAMB415	N	2	0	0	N
MAP3K1	WRIKKLSKG	BREAST	164	p.R162fs	c.485_485delG	Frame_Shift_Del	5	0.11	MDAMB415	N	3	0	24	N
MAP3K1	KQGDPSKIA	ENDOMETRIUM	1072	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	2	0.22	HEC1A	N	5	0	0	N
MAP3K1	KQGDPSKIA	ENDOMETRIUM	1072	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	2	0.22	HEC1B	N	5	0	0	N
MAP3K1	SKQGDPSKI	ENDOMETRIUM	1071	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	1	0.22	HEC1A	N	1	0	0	N
MAP3K1	SKQGDPSKI	ENDOMETRIUM	1071	p.S1077fs	c.3231_3231delA	Frame_Shift_Del	1	0.22	HEC1B	N	1	0	0	N
MAP3K1	ACGTFCIHL	LARGE_INTESTINE	350	p.R351C	c.1051C>T	Missense_Mutation	1	0.11	HCT116	Y	6	9	0	N
MAP3K1	ADESPGEVQ	ENDOMETRIUM	229	p.A230D	c.689C>A	Missense_Mutation	1	0.11	HEC108	N	0	0	0	Y
MAP3K1	ADTATDVSK	ENDOMETRIUM	995	p.G996D	c.2987G>A	Missense_Mutation	1	0.11	HEC108	N	0	0	0	N
MAP3K1	ADTILVKCA	LARGE_INTESTINE	684	p.V684A	c.2051T>C	Missense_Mutation	1	0.11	SNU1040	N	4	0	0	N
MAP3K1	AEAIQLVVE	BREAST	866	p.G872V	c.2615G>T	Missense_Mutation	1	0.11	CAMA1	N	2	0	0	N
MAP3K1	AEEEEAVAI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1183	p.L1189V	c.3565T>G	Missense_Mutation	1	0.11	L540	N	6	0	0	N
MAP3K1	AEKHSYHLA	ENDOMETRIUM	1451	p.N1456Y	c.4366A>T	Missense_Mutation	1	0.11	HEC151	N	7	0	0	N
MAP3K1	AIQLVVEDT	BREAST	868	p.G872V	c.2615G>T	Missense_Mutation	1	0.11	CAMA1	N	0	0	0	N
MAP3K1	APSHNTIQK	SOFT_TISSUE	402	p.R405H	c.1214G>A	Missense_Mutation	1	0.11	SKUT1	Y	1	12	0	N
MAP3K1	APSIHSHLS	LARGE_INTESTINE	1470	p.P1474H	c.4421C>A	Missense_Mutation	1	0.11	HCT15	N	3	0	0	N
MAP3K1	APSRNPIQK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	402	p.T407P	c.1219A>C	Missense_Mutation	1	0.11	HT	Y	1	15	0	Y
MAP3K1	ASKGRCSPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	244	p.R249C	c.745C>T	Missense_Mutation	1	0.11	KYO1	N	1	0	0	N
MAP3K1	ASPASKGRC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	241	p.R249C	c.745C>T	Missense_Mutation	1	0.11	KYO1	N	1	0	0	N
MAP3K1	ATTAPSIHS	LARGE_INTESTINE	1467	p.P1474H	c.4421C>A	Missense_Mutation	1	0.11	HCT15	N	0	0	0	N
MAP3K1	AVAIAMAMS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1188	p.L1189V	c.3565T>G	Missense_Mutation	1	0.11	L540	N	0	0	0	N
MAP3K1	AVFGAAARL	LUNG	1387	p.D1388V	c.4163A>T	Missense_Mutation	1	0.11	NCIH1648	N	16	0	0	N
MAP3K1	AWKHGWLER	ENDOMETRIUM	196	p.E200G	c.599A>G	Missense_Mutation	1	0.11	AN3CA	Y	2	11	0	N
MAP3K1	CACGTFCIH	LARGE_INTESTINE	349	p.R351C	c.1051C>T	Missense_Mutation	1	0.11	HCT116	N	0	0	0	N
MAP3K1	CDDSFDCSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1091	p.G1096D	c.3287G>A	Missense_Mutation	1	0.11	HPBALL	N	1	0	0	Y
MAP3K1	CGTFCIHLL	LARGE_INTESTINE	351	p.R351C	c.1051C>T	Missense_Mutation	1	0.11	HCT116	N	10	0	0	N
MAP3K1	CMPAWKHGW	ENDOMETRIUM	193	p.E200G	c.599A>G	Missense_Mutation	1	0.11	AN3CA	N	2	0	0	N
MAP3K1	CPLCRSMWR	LARGE_INTESTINE	488	p.K494M	c.1481A>T	Missense_Mutation	1	0.11	HT55	N	4	0	0	N
MAP3K1	CRSKWRPHD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	491	p.S497P	c.1489T>C	Missense_Mutation	1	0.11	NALM19	N	1	0	0	N
MAP3K1	CRSMWRSHD	LARGE_INTESTINE	491	p.K494M	c.1481A>T	Missense_Mutation	1	0.11	HT55	N	1	0	0	N