Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JAK2 | ACGITPMYH | LARGE_INTESTINE | 74 | p.V80M | c.238G>A | Missense_Mutation | 1 | 0.11 | LS411N | Y | 0 | 10 | 0 | N | ||||||||||||
| JAK2 | ACLMMTEME | LARGE_INTESTINE | 4 | p.T7M | c.20C>T | Missense_Mutation | 1 | 0.11 | LS411N | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | ADAHHYPCK | LARGE_INTESTINE | 377 | p.L383P | c.1148T>C | Missense_Mutation | 1 | 0.11 | HCT15 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | AEFMCMIGN | LARGE_INTESTINE | 1059 | p.R1063C | c.3187C>T | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 4 | 0 | 0 | N | ||||||||||||
| JAK2 | AENENRVKI | ENDOMETRIUM | 984 | p.V984A | c.2951T>C | Missense_Mutation | 1 | 0.11 | EN | Y | 7 | 12 | 0 | N | ||||||||||||
| JAK2 | AGRCNLKLI | URINARY_TRACT | 920 | p.R923C | c.2767C>T | Missense_Mutation | 1 | 0.11 | UMUC1 | Y | 9 | 9 | 0 | N | ||||||||||||
| JAK2 | AGRHNLKLI | ENDOMETRIUM | 920 | p.R923H | c.2768G>A | Missense_Mutation | 1 | 0.11 | HEC59 | Y | 9 | 9 | 0 | N | ||||||||||||
| JAK2 | AHHYPCKEV | LARGE_INTESTINE | 379 | p.L383P | c.1148T>C | Missense_Mutation | 1 | 0.11 | HCT15 | N | 2 | 0 | 0 | N | ||||||||||||
| JAK2 | AHRNYSKSF | SKIN | 586 | p.E592K | c.1774G>A | Missense_Mutation | 1 | 0.11 | SKMEL28 | N | 1 | 0 | 0 | N | ||||||||||||
| JAK2 | AIYNSISYN | ENDOMETRIUM | 199 | p.K207N | c.621G>T | Missense_Mutation | 1 | 0.11 | HEC251 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | AKENNQTPL | LARGE_INTESTINE | 190 | p.D194N | c.580G>A | Missense_Mutation | 1 | 0.11 | HT115 | N | 4 | 0 | 0 | N | ||||||||||||
| JAK2 | AKNILLFRE | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 676 | p.I682F | c.2044A>T | Missense_Mutation | 1 | 0.11 | MHHCALL4 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | AKNILLIGE | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 676 | p.R683G | c.2047A>G | Missense_Mutation | 1 | 0.11 | MUTZ5 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | AKQLAWSMH | ENDOMETRIUM | 654 | p.A660S | c.1978G>T | Missense_Mutation | 1 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| JAK2 | ALRVDQIRN | LARGE_INTESTINE | 1120 | p.D1128N | c.3382G>A | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | ATRNILAEN | ENDOMETRIUM | 978 | p.V984A | c.2951T>C | Missense_Mutation | 1 | 0.11 | EN | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | AWSMHFLEE | ENDOMETRIUM | 658 | p.A660S | c.1978G>T | Missense_Mutation | 1 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | CAKNILLFR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 675 | p.I682F | c.2044A>T | Missense_Mutation | 1 | 0.11 | MHHCALL4 | N | 4 | 0 | 0 | N | ||||||||||||
| JAK2 | CAKNILLIG | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 675 | p.R683G | c.2047A>G | Missense_Mutation | 1 | 0.11 | MUTZ5 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | CGITPMYHN | LARGE_INTESTINE | 75 | p.V80M | c.238G>A | Missense_Mutation | 1 | 0.11 | LS411N | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | CLMMTEMEG | LARGE_INTESTINE | 5 | p.T7M | c.20C>T | Missense_Mutation | 1 | 0.11 | LS411N | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | CMIGNDKQG | LARGE_INTESTINE | 1063 | p.R1063C | c.3187C>T | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 1 | 0 | 0 | N | ||||||||||||
| JAK2 | CNFPNIIDV | LARGE_INTESTINE | 318 | p.D319N | c.955G>A | Missense_Mutation | 1 | 0.11 | HT115 | Y | 8 | 15 | 0 | N | ||||||||||||
| JAK2 | CNLKLIMEY | URINARY_TRACT | 923 | p.R923C | c.2767C>T | Missense_Mutation | 1 | 0.11 | UMUC1 | N | 6 | 0 | 0 | N | ||||||||||||
| JAK2 | CYSAGRCNL | URINARY_TRACT | 917 | p.R923C | c.2767C>T | Missense_Mutation | 1 | 0.11 | UMUC1 | Y | 6 | 9 | 0 | N | ||||||||||||
| JAK2 | CYSAGRHNL | ENDOMETRIUM | 917 | p.R923H | c.2768G>A | Missense_Mutation | 1 | 0.11 | HEC59 | Y | 6 | 9 | 0 | N | ||||||||||||
| JAK2 | DAHHYPCKE | LARGE_INTESTINE | 378 | p.L383P | c.1148T>C | Missense_Mutation | 1 | 0.11 | HCT15 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | DKAHRNYSK | SKIN | 584 | p.E592K | c.1774G>A | Missense_Mutation | 1 | 0.11 | SKMEL28 | N | 1 | 0 | 0 | Y | ||||||||||||
| JAK2 | DLATRNILA | ENDOMETRIUM | 976 | p.V984A | c.2951T>C | Missense_Mutation | 1 | 0.11 | EN | N | 2 | 0 | 0 | N | ||||||||||||
| JAK2 | DLIVNESLG | LARGE_INTESTINE | 544 | p.F547V | c.1639T>G | Missense_Mutation | 1 | 0.11 | SNUC2A | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | DLNSLFTTD | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 804 | p.P811T | c.2431C>A | Missense_Mutation | 1 | 0.11 | MC116 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | DLQLYCNFP | LARGE_INTESTINE | 313 | p.D319N | c.955G>A | Missense_Mutation | 1 | 0.11 | HT115 | N | 1 | 0 | 0 | N | ||||||||||||
| JAK2 | DPVLQVHLY | OVARY | 36 | p.Y42H | c.124T>C | Missense_Mutation | 1 | 0.11 | OVK18 | Y | 12 | 12 | 0 | N | ||||||||||||
| JAK2 | DQIRNNMAG | LARGE_INTESTINE | 1124 | p.D1128N | c.3382G>A | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | DRCPDEIYM | PROSTATE | 1092 | p.G1093R | c.3277G>A | Missense_Mutation | 1 | 0.11 | 22RV1 | Y | 3 | 10 | 0 | N | ||||||||||||
| JAK2 | DTYLKNNKN | ENDOMETRIUM | 635 | p.K640N | c.1920G>T | Missense_Mutation | 1 | 0.11 | JHUEM7 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | DYHILTRKP | LARGE_INTESTINE | 220 | p.R228P | c.683G>C | Missense_Mutation | 1 | 0.11 | CL14 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | EDLIVNESL | LARGE_INTESTINE | 543 | p.F547V | c.1639T>G | Missense_Mutation | 1 | 0.11 | SNUC2A | N | 7 | 0 | 0 | N | ||||||||||||
| JAK2 | EFMCMIGND | LARGE_INTESTINE | 1060 | p.R1063C | c.3187C>T | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | EFVKFGSPD | ENDOMETRIUM | 627 | p.L634P | c.1901T>C | Missense_Mutation | 1 | 0.11 | MFE319 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | ENNQTPLAI | LARGE_INTESTINE | 192 | p.D194N | c.580G>A | Missense_Mutation | 1 | 0.11 | HT115 | N | 2 | 0 | 0 | N | ||||||||||||
| JAK2 | EQDLQLYCN | LARGE_INTESTINE | 311 | p.D319N | c.955G>A | Missense_Mutation | 1 | 0.11 | HT115 | N | 0 | 0 | 0 | N | ||||||||||||
| JAK2 | EVAKQLAWS | ENDOMETRIUM | 652 | p.A660S | c.1978G>T | Missense_Mutation | 1 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| JAK2 | FGSPDTYLK | ENDOMETRIUM | 631 | p.L634P | c.1901T>C | Missense_Mutation | 1 | 0.11 | MFE319 | N | 2 | 0 | 2 | N | ||||||||||||
| JAK2 | FMCMIGNDK | LARGE_INTESTINE | 1061 | p.R1063C | c.3187C>T | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 5 | 0 | 4 | N | ||||||||||||
| JAK2 | FMDLALRVD | LUNG | 1116 | p.R1117M | c.3350G>T | Missense_Mutation | 1 | 0.11 | NCIH358 | N | 2 | 0 | 0 | N | ||||||||||||
| JAK2 | FREEDRKTG | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 682 | p.I682F | c.2044A>T | Missense_Mutation | 1 | 0.11 | MHHCALL4 | N | 1 | 0 | 0 | N | ||||||||||||
| JAK2 | FTKLFKGVR | ENDOMETRIUM | 556 | p.I559L | c.1675A>C | Missense_Mutation | 1 | 0.11 | HEC251 | N | 6 | 0 | 3 | Y | ||||||||||||
| JAK2 | FTTDYELLT | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 809 | p.P811T | c.2431C>A | Missense_Mutation | 1 | 0.11 | MC116 | N | 3 | 0 | 0 | N | ||||||||||||
| JAK2 | FVKFGSPDT | ENDOMETRIUM | 628 | p.L634P | c.1901T>C | Missense_Mutation | 1 | 0.11 | MFE319 | N | 1 | 0 | 8 | N | ||||||||||||
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