Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
HSP90B1	ASQIRELRS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	63	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	1	0.11	KMS11	N	0	0	0	N
HSP90B1	DTIKNLVKN	LARGE_INTESTINE	262	p.K269fs	c.805_805delA	Frame_Shift_Del	1	0.11	SNU175	N	1	0	0	N
HSP90B1	ELRSRKSLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	68	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	1	0	0	N
HSP90B1	IKNLVKNIH	LARGE_INTESTINE	264	p.K269fs	c.805_805delA	Frame_Shift_Del	3	0.11	SNU175	N	1	0	27	N
HSP90B1	IRELRSRKS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	66	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	2	0	23	N
HSP90B1	KNLVKNIHS	LARGE_INTESTINE	265	p.K269fs	c.805_805delA	Frame_Shift_Del	4	0.11	SNU175	N	0	0	0	N
HSP90B1	KSLPSKPKL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	73	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	6	0.11	KMS11	N	17	0	0	N
HSP90B1	LPSKPKLTE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	75	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	6	0.11	KMS11	N	2	0	5	N
HSP90B1	LRSRKSLPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	69	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	2	0	39	N
HSP90B1	NLVKNIHSS	LARGE_INTESTINE	266	p.K269fs	c.805_805delA	Frame_Shift_Del	5	0.11	SNU175	N	2	0	0	Y
HSP90B1	QIRELRSRK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	65	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	3	0.11	KMS11	Y	2	15	0	N
HSP90B1	RELRSRKSL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	67	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	10	0	0	N
HSP90B1	RKSLPSKPK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	72	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	5	0.11	KMS11	N	2	0	0	N
HSP90B1	RSRKSLPSK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	70	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	5	0.11	KMS11	N	3	0	0	N
HSP90B1	SLPSKPKLT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	74	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	6	0.11	KMS11	N	3	0	0	Y
HSP90B1	SQIRELRSR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	64	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	2	0.11	KMS11	N	5	0	0	N
HSP90B1	SRKSLPSKP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	71	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	1	0	0	N
HSP90B1	TIKNLVKNI	LARGE_INTESTINE	263	p.K269fs	c.805_805delA	Frame_Shift_Del	2	0.11	SNU175	Y	3	11	0	N
HSP90B1	DEEETAKES	KIDNEY	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	786O	N	3	0	0	N
HSP90B1	DEEETAKES	THYROID	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	8505C	N	3	0	0	N
HSP90B1	DEEETAKES	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	A3KAW	N	3	0	0	N
HSP90B1	DEEETAKES	PLEURA	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	ACCMESO1	N	3	0	0	N
HSP90B1	DEEETAKES	URINARY_TRACT	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	ACCS	N	3	0	0	N
HSP90B1	DEEETAKES	STOMACH	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	AGS	N	3	0	0	N
HSP90B1	DEEETAKES	PANCREAS	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	ASPC1	N	3	0	0	N
HSP90B1	DEEETAKES	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BDCM	N	3	0	0	N
HSP90B1	DEEETAKES	CENTRAL_NERVOUS_SYSTEM	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BECKER	N	3	0	0	N
HSP90B1	DEEETAKES	KIDNEY	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BFTC909	N	3	0	0	N
HSP90B1	DEEETAKES	UPPER_AERODIGESTIVE_TRACT	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BHY	N	3	0	0	N
HSP90B1	DEEETAKES	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BL70	N	3	0	0	N
HSP90B1	DEEETAKES	BREAST	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BT20	N	3	0	0	N
HSP90B1	DEEETAKES	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	BV173	N	3	0	0	N
HSP90B1	DEEETAKES	LARGE_INTESTINE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	C2BBE1	N	3	0	0	N
HSP90B1	DEEETAKES	SKIN	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	C32	N	3	0	0	N
HSP90B1	DEEETAKES	LIVER	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	C3A	N	3	0	0	N
HSP90B1	DEEETAKES	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CA46	N	3	0	0	N
HSP90B1	DEEETAKES	BREAST	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CAL120	N	3	0	0	N
HSP90B1	DEEETAKES	BREAST	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CAMA1	N	3	0	0	N
HSP90B1	DEEETAKES	LARGE_INTESTINE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CCK81	N	3	0	0	N
HSP90B1	DEEETAKES	SKIN	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CHL1	N	3	0	0	N
HSP90B1	DEEETAKES	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CMLT1	N	3	0	0	N
HSP90B1	DEEETAKES	LARGE_INTESTINE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	COLO205	N	3	0	0	N
HSP90B1	DEEETAKES	SKIN	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	COLO792	N	3	0	0	N
HSP90B1	DEEETAKES	OVARY	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	COV504	N	3	0	0	N
HSP90B1	DEEETAKES	LARGE_INTESTINE	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	CW2	N	3	0	0	N
HSP90B1	DEEETAKES	CENTRAL_NERVOUS_SYSTEM	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	D341MED	N	3	0	0	N
HSP90B1	DEEETAKES	LUNG	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	EBC1	N	3	0	0	N
HSP90B1	DEEETAKES	ENDOMETRIUM	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	EN	N	3	0	0	N
HSP90B1	DEEETAKES	STOMACH	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	GCIY	N	3	0	0	N
HSP90B1	DEEETAKES	CENTRAL_NERVOUS_SYSTEM	787	p.E791del	c.2362_2364delGAA	In_Frame_Del	1	21.79	GMS10	N	3	0	0	N