Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
HSP90B1	ASQIRELRS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	63	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	1	0.11	KMS11	N	0	0	0	N
HSP90B1	DTIKNLVKN	LARGE_INTESTINE	262	p.K269fs	c.805_805delA	Frame_Shift_Del	1	0.11	SNU175	N	1	0	0	N
HSP90B1	ELRSRKSLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	68	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	1	0	0	N
HSP90B1	IKNLVKNIH	LARGE_INTESTINE	264	p.K269fs	c.805_805delA	Frame_Shift_Del	3	0.11	SNU175	N	1	0	27	N
HSP90B1	IRELRSRKS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	66	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	2	0	23	N
HSP90B1	KNLVKNIHS	LARGE_INTESTINE	265	p.K269fs	c.805_805delA	Frame_Shift_Del	4	0.11	SNU175	N	0	0	0	N
HSP90B1	KSLPSKPKL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	73	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	6	0.11	KMS11	N	17	0	0	N
HSP90B1	LPSKPKLTE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	75	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	6	0.11	KMS11	N	2	0	5	N
HSP90B1	LRSRKSLPS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	69	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	2	0	39	N
HSP90B1	NLVKNIHSS	LARGE_INTESTINE	266	p.K269fs	c.805_805delA	Frame_Shift_Del	5	0.11	SNU175	N	2	0	0	Y
HSP90B1	QIRELRSRK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	65	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	3	0.11	KMS11	Y	2	15	0	N
HSP90B1	RELRSRKSL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	67	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	10	0	0	N
HSP90B1	RKSLPSKPK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	72	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	5	0.11	KMS11	N	2	0	0	N
HSP90B1	RSRKSLPSK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	70	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	5	0.11	KMS11	N	3	0	0	N
HSP90B1	SLPSKPKLT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	74	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	6	0.11	KMS11	N	3	0	0	Y
HSP90B1	SQIRELRSR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	64	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	2	0.11	KMS11	N	5	0	0	N
HSP90B1	SRKSLPSKP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	71	p.R70fs	c.208_211delAGAG	Frame_Shift_Del	4	0.11	KMS11	N	1	0	0	N
HSP90B1	TIKNLVKNI	LARGE_INTESTINE	263	p.K269fs	c.805_805delA	Frame_Shift_Del	2	0.11	SNU175	Y	3	11	0	N
HSP90B1	AGSIRKEAE	LARGE_INTESTINE	542	p.S545I	c.1634G>T	Missense_Mutation	1	0.11	HRT18	N	0	0	0	N
HSP90B1	AIQLDGLNS	LARGE_INTESTINE	55	p.A63S	c.187G>T	Missense_Mutation	1	0.11	HT115	N	0	0	0	N
HSP90B1	AITLVLKEE	ENDOMETRIUM	246	p.T246A	c.736A>G	Missense_Mutation	1	0.11	JHUEM2	N	0	0	0	N
HSP90B1	AKVEEEPKE	ENDOMETRIUM	753	p.E760K	c.2278G>A	Missense_Mutation	1	0.11	JHUEM7	N	0	0	0	N
HSP90B1	AKVEEQPEE	LUNG	753	p.E758Q	c.2272G>C	Missense_Mutation	1	0.11	NCIH2342	N	0	0	0	N
HSP90B1	ALPKFDGKR	LARGE_INTESTINE	579	p.E582K	c.1744G>A	Missense_Mutation	1	0.11	SNU81	N	6	0	0	N
HSP90B1	AQEDGQSIS	URINARY_TRACT	181	p.T188I	c.563C>T	Missense_Mutation	1	0.11	ACCS	N	0	0	0	N
HSP90B1	ATLRSGYLS	BREAST	721	p.L729S	c.2186T>C	Missense_Mutation	1	0.11	UACC812	N	0	0	0	N
HSP90B1	AYQTGKDNS	CENTRAL_NERVOUS_SYSTEM	666	p.I673N	c.2018T>A	Missense_Mutation	1	0.11	A172	N	2	0	0	N
HSP90B1	CASQKKTFE	ENDOMETRIUM	678	p.Y678C	c.2033A>G	Missense_Mutation	1	0.11	EN	N	0	0	0	N
HSP90B1	CIQALPKFD	LARGE_INTESTINE	576	p.E582K	c.1744G>A	Missense_Mutation	1	0.11	SNU81	N	0	0	0	N
HSP90B1	CRVFITDDF	LUNG	414	p.R414C	c.1240C>T	Missense_Mutation	1	0.11	NCIH1781	N	4	0	0	N
HSP90B1	DAKVEEEPK	ENDOMETRIUM	752	p.E760K	c.2278G>A	Missense_Mutation	1	0.11	JHUEM7	N	1	0	0	N
HSP90B1	DAKVEEQPE	LUNG	752	p.E758Q	c.2272G>C	Missense_Mutation	1	0.11	NCIH2342	N	0	0	0	N
HSP90B1	DEYGFKKSD	SKIN	399	p.S403F	c.1208C>T	Missense_Mutation	1	0.11	HS936T	N	1	0	0	N
HSP90B1	DGLNSSQIR	LARGE_INTESTINE	59	p.A63S	c.187G>T	Missense_Mutation	1	0.11	HT115	N	1	0	0	N
HSP90B1	DGPMAYIHF	UPPER_AERODIGESTIVE_TRACT	367	p.D368G	c.1103A>G	Missense_Mutation	1	0.11	CAL33	Y	7	9	0	N
HSP90B1	DGQSISELI	URINARY_TRACT	184	p.T188I	c.563C>T	Missense_Mutation	1	0.11	ACCS	N	7	0	0	N
HSP90B1	DISTNYCAS	ENDOMETRIUM	672	p.Y678C	c.2033A>G	Missense_Mutation	1	0.11	EN	N	2	0	0	N
HSP90B1	DKIYFIAGS	BREAST	536	p.M541I	c.1623G>A	Missense_Mutation	1	0.11	BT474	N	2	0	0	N
HSP90B1	DMLQRIKED	ENDOMETRIUM	696	p.R699Q	c.2096G>A	Missense_Mutation	1	0.11	HEC251	N	0	0	0	N
HSP90B1	DNSTNYYAS	CENTRAL_NERVOUS_SYSTEM	672	p.I673N	c.2018T>A	Missense_Mutation	1	0.11	A172	N	1	0	0	N
HSP90B1	DPDAKVEEQ	LUNG	750	p.E758Q	c.2272G>C	Missense_Mutation	1	0.11	NCIH2342	N	0	0	0	N
HSP90B1	DYIKLYVCR	LUNG	407	p.R414C	c.1240C>T	Missense_Mutation	1	0.11	NCIH1781	Y	2	10	0	N
HSP90B1	EAQEDGQSI	URINARY_TRACT	180	p.T188I	c.563C>T	Missense_Mutation	1	0.11	ACCS	N	5	0	0	N
HSP90B1	EDGQSISEL	URINARY_TRACT	183	p.T188I	c.563C>T	Missense_Mutation	1	0.11	ACCS	N	6	0	0	N
HSP90B1	EEEPKEEPE	ENDOMETRIUM	756	p.E760K	c.2278G>A	Missense_Mutation	1	0.11	JHUEM7	N	0	0	0	N
HSP90B1	EEPKEEPEE	ENDOMETRIUM	757	p.E760K	c.2278G>A	Missense_Mutation	1	0.11	JHUEM7	N	0	0	0	N
HSP90B1	EEQPEEEPE	LUNG	756	p.E758Q	c.2272G>C	Missense_Mutation	1	0.11	NCIH2342	N	0	0	0	N
HSP90B1	EKQDKIYFI	BREAST	533	p.M541I	c.1623G>A	Missense_Mutation	1	0.11	BT474	N	4	0	0	N
HSP90B1	ENHSNRTRL	ENDOMETRIUM	498	p.D499N	c.1495G>A	Missense_Mutation	1	0.11	HEC59	Y	6	19	0	Y
HSP90B1	EPKEEPEET	ENDOMETRIUM	758	p.E760K	c.2278G>A	Missense_Mutation	1	0.11	JHUEM7	N	4	0	0	N