Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
GATA1	APPPVCGSC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	13	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	Y	5	10	0	N
GATA1	APPPVCGSC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	13	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	Y	5	10	0	N
GATA1	CGSCSGVLH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	18	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	0	0	0	N
GATA1	CGSCSGVLH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	18	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	0	0	0	N
GATA1	CSGVLHTRI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	4	0	0	N
GATA1	CSGVLHTRI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	21	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	4	0	0	N
GATA1	DLRAPPPVC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	10	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	2	0	0	N
GATA1	DLRAPPPVC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	10	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	2	0	0	N
GATA1	GDLRAPPPV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	9	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	5	0	0	N
GATA1	GDLRAPPPV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	9	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	5	0	0	N
GATA1	GSCSGVLHT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	19	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	1	0	0	N
GATA1	GSCSGVLHT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	19	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	1	0	0	N
GATA1	GVLHTRIRG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	23	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	0	0	0	N
GATA1	GVLHTRIRG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	23	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	0	0	0	N
GATA1	GVPGDLRAP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	6	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	0	0	0	N
GATA1	GVPGDLRAP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	6	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	0	0	0	N
GATA1	HTRIRGFLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	26	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	2	0	0	N
GATA1	HTRIRGFLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	26	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	2	0	0	N
GATA1	IRGFLPLWA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	29	p.E2fs	c.4_5delGA	Frame_Shift_Del	4	0.22	CMK115	N	4	0	41	Y
GATA1	IRGFLPLWA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	29	p.E2fs	c.4_5delGA	Frame_Shift_Del	4	0.22	CMK	N	4	0	41	Y
GATA1	LHTRIRGFL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	25	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	8	0	4	N
GATA1	LHTRIRGFL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	25	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	8	0	4	N
GATA1	LRAPPPVCG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	11	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	1	0	0	N
GATA1	LRAPPPVCG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	11	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	1	0	0	N
GATA1	MVPWPGVPG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	0	0	4	N
GATA1	MVPWPGVPG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	0	0	4	N
GATA1	PGDLRAPPP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	8	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	0	0	0	N
GATA1	PGDLRAPPP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	8	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	0	0	0	N
GATA1	PGVPGDLRA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	5	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	0	0	0	N
GATA1	PGVPGDLRA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	5	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	0	0	0	N
GATA1	PPPVCGSCS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	14	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	0	0	0	N
GATA1	PPPVCGSCS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	14	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	0	0	0	N
GATA1	PPVCGSCSG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	15	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	0	0	0	N
GATA1	PPVCGSCSG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	15	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	0	0	0	N
GATA1	PVCGSCSGV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	16	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	0	0	0	N
GATA1	PVCGSCSGV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	16	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	0	0	0	N
GATA1	PWPGVPGDL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	0	0	0	N
GATA1	PWPGVPGDL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	0	0	0	N
GATA1	RAPPPVCGS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	12	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	2	0	0	N
GATA1	RAPPPVCGS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	12	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	2	0	0	N
GATA1	RIRGFLPLW	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	28	p.E2fs	c.4_5delGA	Frame_Shift_Del	4	0.22	CMK115	Y	5	10	0	N
GATA1	RIRGFLPLW	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	28	p.E2fs	c.4_5delGA	Frame_Shift_Del	4	0.22	CMK	Y	5	10	0	N
GATA1	SCSGVLHTR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	20	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	Y	4	9	0	N
GATA1	SCSGVLHTR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	20	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	Y	4	9	0	N
GATA1	SGVLHTRIR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	22	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	1	0	0	N
GATA1	SGVLHTRIR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	22	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	1	0	0	N
GATA1	TRIRGFLPL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	27	p.E2fs	c.4_5delGA	Frame_Shift_Del	4	0.22	CMK115	N	9	0	0	N
GATA1	TRIRGFLPL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	27	p.E2fs	c.4_5delGA	Frame_Shift_Del	4	0.22	CMK	N	9	0	0	N
GATA1	VCGSCSGVL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	17	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	6	0	2	N
GATA1	VCGSCSGVL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	17	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	6	0	2	N
GATA1	VLHTRIRGF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	24	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	Y	6	9	3	N
GATA1	VLHTRIRGF	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	24	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	Y	6	9	3	N
GATA1	VPGDLRAPP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK115	N	2	0	0	Y
GATA1	VPGDLRAPP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	7	p.E2fs	c.4_5delGA	Frame_Shift_Del	5	0.22	CMK	N	2	0	0	Y
GATA1	VPWPGVPGD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	2	0	0	N
GATA1	VPWPGVPGD	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	2	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	2	0	0	N
GATA1	WPGVPGDLR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	4	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK115	N	6	0	0	N
GATA1	WPGVPGDLR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	4	p.E2fs	c.4_5delGA	Frame_Shift_Del	6	0.22	CMK	N	6	0	0	N