Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FGFR2 | PHINGSVKH | ENDOMETRIUM | 814 | p.T822fs | c.2464_2464delA | Frame_Shift_Del | 1 | 0.11 | ISHIKAWAHERAKLIO02ER | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | ADTPHAGRG | LARGE_INTESTINE | 456 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 5 | 0.11 | SNUC4 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | DTPHAGRGL | LARGE_INTESTINE | 457 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 6 | 0.11 | SNUC4 | N | 6 | 0 | 0 | N | ||||||||||||
| FGFR2 | LSSTADTPH | LARGE_INTESTINE | 452 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 1 | 0.11 | SNUC4 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | PHAGRGLRV | LARGE_INTESTINE | 459 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 6 | 0.11 | SNUC4 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | SSTADTPHA | LARGE_INTESTINE | 453 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 2 | 0.11 | SNUC4 | N | 1 | 0 | 0 | Y | ||||||||||||
| FGFR2 | STADTPHAG | LARGE_INTESTINE | 454 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 3 | 0.11 | SNUC4 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | TADTPHAGR | LARGE_INTESTINE | 455 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 4 | 0.11 | SNUC4 | N | 4 | 0 | 0 | N | ||||||||||||
| FGFR2 | TPHAGRGLR | LARGE_INTESTINE | 458 | p.P459fs | c.1377_1378insC | Frame_Shift_Ins | 6 | 0.11 | SNUC4 | N | 4 | 0 | 0 | N | ||||||||||||
| FGFR2 | AARNVLVTK | SKIN | 629 | p.E637K | c.1909G>A | Missense_Mutation | 1 | 0.11 | A375 | Y | 2 | 14 | 0 | Y | ||||||||||||
| FGFR2 | ACTASSTVD | UPPER_AERODIGESTIVE_TRACT | 106 | p.R111S | c.333G>C | Missense_Mutation | 1 | 0.11 | SNU899 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | ACTQNGPLY | SKIN | 554 | p.D558N | c.1672G>A | Missense_Mutation | 1 | 0.11 | COLO679 | N | 4 | 0 | 0 | N | ||||||||||||
| FGFR2 | ADAGEYICN | ENDOMETRIUM | 333 | p.K341N | c.1023G>T | Missense_Mutation | 1 | 0.11 | HEC251 | N | 1 | 0 | 0 | N | ||||||||||||
| FGFR2 | AEVFVSENS | LARGE_INTESTINE | 140 | p.D142V | c.425A>T | Missense_Mutation | 1 | 0.11 | SNU283 | N | 5 | 0 | 0 | N | ||||||||||||
| FGFR2 | AGEYICNVS | ENDOMETRIUM | 335 | p.K341N | c.1023G>T | Missense_Mutation | 1 | 0.11 | HEC251 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | AGGNPMSTM | LARGE_INTESTINE | 181 | p.P187S | c.559C>T | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 5 | 0 | 0 | N | ||||||||||||
| FGFR2 | AIYRIGVFL | ENDOMETRIUM | 380 | p.C383R | c.1147T>C | Missense_Mutation | 1 | 0.11 | JHUEM2 | N | 15 | 0 | 0 | N | ||||||||||||
| FGFR2 | APGRKKEIT | LUNG | 363 | p.E367K | c.1099G>A | Missense_Mutation | 1 | 0.11 | SBC5 | N | 6 | 0 | 0 | N | ||||||||||||
| FGFR2 | ARNVLVTKN | SKIN | 630 | p.E637K | c.1909G>A | Missense_Mutation | 1 | 0.11 | A375 | N | 2 | 0 | 0 | N | ||||||||||||
| FGFR2 | ARRPLGMEY | LARGE_INTESTINE | 579 | p.P583L | c.1748C>T | Missense_Mutation | 1 | 0.11 | HCT116 | Y | 3 | 10 | 0 | N | ||||||||||||
| FGFR2 | ARRPPGMEH | ENDOMETRIUM | 579 | p.Y587H | c.1759T>C | Missense_Mutation | 1 | 0.11 | EN | Y | 2 | 11 | 0 | Y | ||||||||||||
| FGFR2 | ASSTVDSET | UPPER_AERODIGESTIVE_TRACT | 109 | p.R111S | c.333G>C | Missense_Mutation | 1 | 0.11 | SNU899 | N | 1 | 0 | 0 | N | ||||||||||||
| FGFR2 | ATGMEYLAS | LUNG | 612 | p.R613T | c.1838G>C | Missense_Mutation | 1 | 0.11 | NCIH2009 | N | 1 | 0 | 0 | N | ||||||||||||
| FGFR2 | AVHKLTKRM | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 415 | p.I423M | c.1269C>G | Missense_Mutation | 1 | 0.11 | OCIM1 | N | 3 | 0 | 0 | N | ||||||||||||
| FGFR2 | AVHKLTKRV | LARGE_INTESTINE | 415 | p.I423V | c.1267A>G | Missense_Mutation | 1 | 0.11 | GP2D | N | 2 | 0 | 0 | N | ||||||||||||
| FGFR2 | AVTVVVKML | ENDOMETRIUM | 512 | p.A516V | c.1547C>T | Missense_Mutation | 1 | 0.11 | HEC59 | Y | 7 | 10 | 0 | N | ||||||||||||
| FGFR2 | AYTPMLAGV | LARGE_INTESTINE | 456 | p.D457Y | c.1369G>T | Missense_Mutation | 1 | 0.11 | SNU175 | N | 3 | 0 | 0 | N | ||||||||||||
| FGFR2 | CIGGYKVRN | BREAST | 203 | p.R203C | c.607C>T | Missense_Mutation | 1 | 0.11 | HCC1143 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | CLPQYTHIN | PANCREAS | 809 | p.P814T | c.2440C>A | Missense_Mutation | 1 | 0.11 | PSN1 | N | 2 | 0 | 0 | N | ||||||||||||
| FGFR2 | CNVSNYIGQ | ENDOMETRIUM | 340 | p.K341N | c.1023G>T | Missense_Mutation | 1 | 0.11 | HEC251 | N | 0 | 0 | 0 | Y | ||||||||||||
| FGFR2 | CPAGGNPMS | LARGE_INTESTINE | 179 | p.P187S | c.559C>T | Missense_Mutation | 1 | 0.11 | SNU1040 | N | 3 | 0 | 0 | N | ||||||||||||
| FGFR2 | CQMKNTTKK | STOMACH | 399 | p.R400Q | c.1199G>A | Missense_Mutation | 1 | 0.11 | MKN74 | N | 6 | 0 | 0 | N | ||||||||||||
| FGFR2 | CRMKNMTKK | PLEURA | 399 | p.T404M | c.1211C>T | Missense_Mutation | 1 | 0.11 | MSTO211H | N | 2 | 0 | 0 | N | ||||||||||||
| FGFR2 | CTASSTVDS | UPPER_AERODIGESTIVE_TRACT | 107 | p.R111S | c.333G>C | Missense_Mutation | 1 | 0.11 | SNU899 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | CTQNGPLYV | SKIN | 555 | p.D558N | c.1672G>A | Missense_Mutation | 1 | 0.11 | COLO679 | Y | 2 | 12 | 0 | N | ||||||||||||
| FGFR2 | CTYQLATGM | LUNG | 607 | p.R613T | c.1838G>C | Missense_Mutation | 1 | 0.11 | NCIH2009 | N | 5 | 0 | 0 | N | ||||||||||||
| FGFR2 | DAGEYICNV | ENDOMETRIUM | 334 | p.K341N | c.1023G>T | Missense_Mutation | 1 | 0.11 | HEC251 | Y | 4 | 9 | 0 | N | ||||||||||||
| FGFR2 | DDTDGAEVF | LARGE_INTESTINE | 135 | p.D142V | c.425A>T | Missense_Mutation | 1 | 0.11 | SNU283 | N | 5 | 0 | 0 | N | ||||||||||||
| FGFR2 | DGAEVFVSE | LARGE_INTESTINE | 138 | p.D142V | c.425A>T | Missense_Mutation | 1 | 0.11 | SNU283 | N | 0 | 0 | 0 | Y | ||||||||||||
| FGFR2 | DGLPYLRVL | ENDOMETRIUM | 304 | p.K310R | c.929A>G | Missense_Mutation | 1 | 0.11 | AN3CA | N | 17 | 0 | 0 | N | ||||||||||||
| FGFR2 | DGPLYVVVE | BILIARY_TRACT | 558 | p.I564V | c.1690A>G | Missense_Mutation | 1 | 0.11 | SNU245 | N | 1 | 0 | 0 | N | ||||||||||||
| FGFR2 | DKDKPKETV | LARGE_INTESTINE | 505 | p.A512T | c.1534G>A | Missense_Mutation | 1 | 0.11 | SNU503 | N | 1 | 0 | 0 | N | ||||||||||||
| FGFR2 | DKPKETVTV | LARGE_INTESTINE | 507 | p.A512T | c.1534G>A | Missense_Mutation | 1 | 0.11 | SNU503 | N | 2 | 0 | 0 | N | ||||||||||||
| FGFR2 | DPMPYEPYL | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 802 | p.C809Y | c.2426G>A | Missense_Mutation | 1 | 0.11 | RCHACV | Y | 19 | 10 | 0 | N | ||||||||||||
| FGFR2 | DTDGAEVFV | LARGE_INTESTINE | 136 | p.D142V | c.425A>T | Missense_Mutation | 1 | 0.11 | SNU283 | Y | 3 | 11 | 0 | N | ||||||||||||
| FGFR2 | DYLEIAIYR | ENDOMETRIUM | 375 | p.C383R | c.1147T>C | Missense_Mutation | 1 | 0.11 | JHUEM2 | Y | 2 | 9 | 0 | N | ||||||||||||
| FGFR2 | EAVTVVVKM | ENDOMETRIUM | 511 | p.A516V | c.1547C>T | Missense_Mutation | 1 | 0.11 | HEC59 | N | 8 | 0 | 0 | N | ||||||||||||
| FGFR2 | EDDTDGAEV | LARGE_INTESTINE | 134 | p.D142V | c.425A>T | Missense_Mutation | 1 | 0.11 | SNU283 | N | 3 | 0 | 0 | N | ||||||||||||
| FGFR2 | EFKQEHCIG | BREAST | 197 | p.R203C | c.607C>T | Missense_Mutation | 1 | 0.11 | HCC1143 | N | 0 | 0 | 0 | N | ||||||||||||
| FGFR2 | EHCIGGYKV | BREAST | 201 | p.R203C | c.607C>T | Missense_Mutation | 1 | 0.11 | HCC1143 | N | 2 | 0 | 0 | N | ||||||||||||
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