Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ERBB2 | LTEILKGGS | BREAST | 145 | p.G152fs | c.454_454delG | Frame_Shift_Del | 1 | 0.11 | MDAMB468 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | AVCVGSPYV | LUNG | 775 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 3 | 0.11 | NCIH1781 | Y | 2 | 11 | 0 | N | ||||||||||||
| ERBB2 | AYVMAVCVG | LUNG | 771 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 4 | 0.11 | NCIH1781 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | CVGSPYVSR | LUNG | 777 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 1 | 0.11 | NCIH1781 | Y | 6 | 10 | 0 | N | ||||||||||||
| ERBB2 | DEAYVMAVC | LUNG | 769 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 2 | 0.11 | NCIH1781 | N | 6 | 0 | 0 | N | ||||||||||||
| ERBB2 | EAYVMAVCV | LUNG | 770 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 3 | 0.11 | NCIH1781 | N | 6 | 0 | 0 | N | ||||||||||||
| ERBB2 | MAVCVGSPY | LUNG | 774 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 4 | 0.11 | NCIH1781 | N | 8 | 0 | 0 | N | ||||||||||||
| ERBB2 | VCVGSPYVS | LUNG | 776 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 2 | 0.11 | NCIH1781 | N | 0 | 0 | 1 | N | ||||||||||||
| ERBB2 | VMAVCVGSP | LUNG | 773 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 5 | 0.11 | NCIH1781 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | YVMAVCVGS | LUNG | 772 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 5 | 0.11 | NCIH1781 | N | 2 | 0 | 48 | N | ||||||||||||
| ERBB2 | LDEAYVMAV | LUNG | 768 | p.776_776G>VC | c.2326_2327insTGT | In_Frame_Ins | 1 | 0.22 | NCIH1781 | N | 7 | 0 | 0 | N | ||||||||||||
| ERBB2 | AAVGILLVV | ENDOMETRIUM | 657 | p.V658A | c.1973T>C | Missense_Mutation | 1 | 0.11 | HEC265 | N | 7 | 0 | 0 | N | ||||||||||||
| ERBB2 | AEDGSQRCE | LUNG | 324 | p.T328S | c.982A>T | Missense_Mutation | 1 | 0.11 | HCC1359 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | AEHRASPLT | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 644 | p.Q646H | c.1938G>C | Missense_Mutation | 1 | 0.11 | BCP1 | N | 6 | 0 | 0 | Y | ||||||||||||
| ERBB2 | AFNPAFDNL | ENDOMETRIUM | 1212 | p.S1214N | c.3641G>A | Missense_Mutation | 1 | 0.11 | HEC59 | Y | 7 | 11 | 0 | N | ||||||||||||
| ERBB2 | AGGCAHCKG | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 221 | p.R226H | c.677G>A | Missense_Mutation | 1 | 0.11 | NALM6 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | AHCKGPLPT | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 225 | p.R226H | c.677G>A | Missense_Mutation | 1 | 0.11 | NALM6 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | ALESILHRR | ENDOMETRIUM | 890 | p.R896H | c.2687G>A | Missense_Mutation | 1 | 0.11 | MFE319 | Y | 6 | 9 | 0 | N | ||||||||||||
| ERBB2 | ARCKGLLPT | LARGE_INTESTINE | 225 | p.P230L | c.689C>T | Missense_Mutation | 1 | 0.11 | KM12 | N | 2 | 0 | 0 | N | ||||||||||||
| ERBB2 | ASPLTCIIS | URINARY_TRACT | 648 | p.S653C | c.1958C>G | Missense_Mutation | 1 | 0.11 | VMCUB1 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | AVGILLVVV | ENDOMETRIUM | 658 | p.V658A | c.1973T>C | Missense_Mutation | 1 | 0.11 | HEC265 | Y | 5 | 10 | 0 | N | ||||||||||||
| ERBB2 | AVVGSPYVS | OVARY | 775 | p.G776V | c.2327G>T | Missense_Mutation | 1 | 0.11 | OVCAR8 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | AYVMAVVGS | OVARY | 771 | p.G776V | c.2327G>T | Missense_Mutation | 1 | 0.11 | OVCAR8 | N | 2 | 0 | 0 | N | ||||||||||||
| ERBB2 | CAGGCAHCK | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 220 | p.R226H | c.677G>A | Missense_Mutation | 1 | 0.11 | NALM6 | N | 2 | 0 | 0 | N | ||||||||||||
| ERBB2 | CAHCKGPLP | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 224 | p.R226H | c.677G>A | Missense_Mutation | 1 | 0.11 | NALM6 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | CARCKGLLP | LARGE_INTESTINE | 224 | p.P230L | c.689C>T | Missense_Mutation | 1 | 0.11 | KM12 | N | 1 | 0 | 0 | Y | ||||||||||||
| ERBB2 | CCKPCARVC | LUNG | 334 | p.S335C | c.1003A>T | Missense_Mutation | 1 | 0.11 | NCIH1563 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | CEKCCKPCA | LUNG | 331 | p.S335C | c.1003A>T | Missense_Mutation | 1 | 0.11 | NCIH1563 | N | 6 | 0 | 0 | N | ||||||||||||
| ERBB2 | CIISAVVGI | URINARY_TRACT | 653 | p.S653C | c.1958C>G | Missense_Mutation | 1 | 0.11 | VMCUB1 | N | 6 | 0 | 0 | N | ||||||||||||
| ERBB2 | CKGLLPTDC | LARGE_INTESTINE | 227 | p.P230L | c.689C>T | Missense_Mutation | 1 | 0.11 | KM12 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | CKPCARVCY | LUNG | 335 | p.S335C | c.1003A>T | Missense_Mutation | 1 | 0.11 | NCIH1563 | N | 2 | 0 | 0 | N | ||||||||||||
| ERBB2 | CMEECRVLQ | LUNG | 540 | p.V541M | c.1621G>A | Missense_Mutation | 1 | 0.11 | NCIH1793 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | CPAEHRASP | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 642 | p.Q646H | c.1938G>C | Missense_Mutation | 1 | 0.11 | BCP1 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | CPLHYQEVT | LUNG | 315 | p.N319Y | c.955A>T | Missense_Mutation | 1 | 0.11 | NCIH2110 | N | 5 | 0 | 0 | N | ||||||||||||
| ERBB2 | CQSLTHTVC | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 212 | p.R217H | c.650G>A | Missense_Mutation | 1 | 0.11 | MOLT16 | N | 3 | 0 | 0 | N | ||||||||||||
| ERBB2 | CTIVCPLHN | LARGE_INTESTINE | 311 | p.L313I | c.937C>A | Missense_Mutation | 1 | 0.11 | HRT18 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | CTLVCPLHY | LUNG | 311 | p.N319Y | c.955A>T | Missense_Mutation | 1 | 0.11 | NCIH2110 | N | 7 | 0 | 0 | N | ||||||||||||
| ERBB2 | DCQSLTHTV | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 211 | p.R217H | c.650G>A | Missense_Mutation | 1 | 0.11 | MOLT16 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | DDKGCPAEH | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 638 | p.Q646H | c.1938G>C | Missense_Mutation | 1 | 0.11 | BCP1 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | DEAYVMAVV | OVARY | 769 | p.G776V | c.2327G>T | Missense_Mutation | 1 | 0.11 | OVCAR8 | N | 7 | 0 | 0 | N | ||||||||||||
| ERBB2 | DGKNVKIPV | LARGE_INTESTINE | 742 | p.E744K | c.2230G>A | Missense_Mutation | 1 | 0.11 | LS411N | N | 5 | 0 | 0 | N | ||||||||||||
| ERBB2 | DGSQRCEKC | LUNG | 326 | p.T328S | c.982A>T | Missense_Mutation | 1 | 0.11 | HCC1359 | N | 2 | 0 | 0 | N | ||||||||||||
| ERBB2 | DKGCPAEHR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 639 | p.Q646H | c.1938G>C | Missense_Mutation | 1 | 0.11 | BCP1 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | DVGFCTLVC | URINARY_TRACT | 307 | p.S310F | c.929C>T | Missense_Mutation | 1 | 0.11 | 5637 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | DVGSCTIVC | LARGE_INTESTINE | 307 | p.L313I | c.937C>A | Missense_Mutation | 1 | 0.11 | HRT18 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | EAYVMAVVG | OVARY | 770 | p.G776V | c.2327G>T | Missense_Mutation | 1 | 0.11 | OVCAR8 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | ECMEECRVL | LUNG | 539 | p.V541M | c.1621G>A | Missense_Mutation | 1 | 0.11 | NCIH1793 | N | 10 | 0 | 0 | N | ||||||||||||
| ERBB2 | EDCQSLTHT | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 210 | p.R217H | c.650G>A | Missense_Mutation | 1 | 0.11 | MOLT16 | N | 1 | 0 | 0 | N | ||||||||||||
| ERBB2 | EDGSQRCEK | LUNG | 325 | p.T328S | c.982A>T | Missense_Mutation | 1 | 0.11 | HCC1359 | N | 0 | 0 | 0 | N | ||||||||||||
| ERBB2 | EHRASPLTS | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 645 | p.Q646H | c.1938G>C | Missense_Mutation | 1 | 0.11 | BCP1 | N | 0 | 0 | 0 | N | ||||||||||||
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