Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
EGFR	ATQSACLRP	LARGE_INTESTINE	558	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	0	0	0	N
EGFR	AYSATQSAC	LARGE_INTESTINE	555	p.E543fs	c.1629_1629delG	Frame_Shift_Del	6	0.11	CW2	N	2	0	0	N
EGFR	CNLLEVSQG	LARGE_INTESTINE	539	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	0	0	0	N
EGFR	CRGIMIFPS	OESOPHAGUS	70	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	2	0	0	N
EGFR	DKCNLLEVS	LARGE_INTESTINE	537	p.E543fs	c.1629_1629delG	Frame_Shift_Del	2	0.11	CW2	N	1	0	0	N
EGFR	EITMCRGIM	OESOPHAGUS	66	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	2	0	0	N
EGFR	EVSQGSLWR	LARGE_INTESTINE	543	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	Y	5	9	0	Y
EGFR	GNLEITMCR	OESOPHAGUS	63	p.T68fs	c.203_203delC	Frame_Shift_Del	3	0.11	KYSE70	N	2	0	0	N
EGFR	GSLWRTLSA	LARGE_INTESTINE	547	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	3	0	0	Y
EGFR	ITMCRGIMI	OESOPHAGUS	67	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	Y	9	15	8	N
EGFR	KCNLLEVSQ	LARGE_INTESTINE	538	p.E543fs	c.1629_1629delG	Frame_Shift_Del	3	0.11	CW2	N	0	0	0	N
EGFR	LEITMCRGI	OESOPHAGUS	65	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	8	0	7	N
EGFR	LEVSQGSLW	LARGE_INTESTINE	542	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	8	0	0	N
EGFR	LGNLEITMC	OESOPHAGUS	62	p.T68fs	c.203_203delC	Frame_Shift_Del	2	0.11	KYSE70	N	0	0	3	N
EGFR	LLEVSQGSL	LARGE_INTESTINE	541	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	9	0	0	N
EGFR	LSAYSATQS	LARGE_INTESTINE	553	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	0	0	1	N
EGFR	LWRTLSAYS	LARGE_INTESTINE	549	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	0	0	4	Y
EGFR	MCRGIMIFP	OESOPHAGUS	69	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	0	0	0	N
EGFR	NLEITMCRG	OESOPHAGUS	64	p.T68fs	c.203_203delC	Frame_Shift_Del	4	0.11	KYSE70	N	1	0	0	N
EGFR	NLLEVSQGS	LARGE_INTESTINE	540	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	0	0	0	N
EGFR	QGSLWRTLS	LARGE_INTESTINE	546	p.E543fs	c.1629_1629delG	Frame_Shift_Del	6	0.11	CW2	N	0	0	0	Y
EGFR	RTLSAYSAT	LARGE_INTESTINE	551	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	2	0	0	N
EGFR	SATQSACLR	LARGE_INTESTINE	557	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	3	0	0	N
EGFR	SAYSATQSA	LARGE_INTESTINE	554	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	4	0	0	N
EGFR	SLWRTLSAY	LARGE_INTESTINE	548	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	Y	7	15	0	Y
EGFR	SQGSLWRTL	LARGE_INTESTINE	545	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	Y	8	12	0	N
EGFR	TLSAYSATQ	LARGE_INTESTINE	552	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	1	0	0	N
EGFR	TMCRGIMIF	OESOPHAGUS	68	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	Y	6	9	0	N
EGFR	VDKCNLLEV	LARGE_INTESTINE	536	p.E543fs	c.1629_1629delG	Frame_Shift_Del	1	0.11	CW2	N	5	0	0	N
EGFR	VLGNLEITM	OESOPHAGUS	61	p.T68fs	c.203_203delC	Frame_Shift_Del	1	0.11	KYSE70	N	6	0	0	N
EGFR	VSQGSLWRT	LARGE_INTESTINE	544	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	1	0	0	Y
EGFR	WRTLSAYSA	LARGE_INTESTINE	550	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	5	0	24	N
EGFR	YSATQSACL	LARGE_INTESTINE	556	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	11	0	2	N
EGFR	AIKEATSPK	LUNG	743	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	3	0.11	HCC4006	N	2	0	0	N
EGFR	IKEATSPKA	LUNG	744	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	2	0.11	HCC4006	N	2	0	0	N
EGFR	IPVAIKEAT	LUNG	740	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	2	0.11	HCC4006	N	6	0	0	N
EGFR	KEATSPKAN	LUNG	745	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	1	0.11	HCC4006	N	4	0	0	N
EGFR	KIPVAIKEA	LUNG	739	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	1	0.11	HCC4006	N	4	0	0	N
EGFR	PVAIKEATS	LUNG	741	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	3	0.11	HCC4006	N	0	0	0	N
EGFR	VAIKEATSP	LUNG	742	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	4	0.11	HCC4006	N	0	0	1	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC2279	N	0	0	0	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC827	N	0	0	0	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	3	0.44	NCIH1650	N	0	0	0	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	3	0.44	PC14	N	0	0	0	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	2	0.44	HCC2279	N	1	0	6	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	2	0.44	HCC827	N	1	0	6	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	2	0.44	NCIH1650	N	1	0	6	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	2	0.44	PC14	N	1	0	6	N
EGFR	IPVAIKTSP	LUNG	740	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC2279	N	2	0	0	N
EGFR	IPVAIKTSP	LUNG	740	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC827	N	2	0	0	N