Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
EGFR	ATQSACLRP	LARGE_INTESTINE	558	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	0	0	0	N
EGFR	AYSATQSAC	LARGE_INTESTINE	555	p.E543fs	c.1629_1629delG	Frame_Shift_Del	6	0.11	CW2	N	2	0	0	N
EGFR	CNLLEVSQG	LARGE_INTESTINE	539	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	0	0	0	N
EGFR	CRGIMIFPS	OESOPHAGUS	70	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	2	0	0	N
EGFR	DKCNLLEVS	LARGE_INTESTINE	537	p.E543fs	c.1629_1629delG	Frame_Shift_Del	2	0.11	CW2	N	1	0	0	N
EGFR	EITMCRGIM	OESOPHAGUS	66	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	2	0	0	N
EGFR	EVSQGSLWR	LARGE_INTESTINE	543	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	Y	5	9	0	Y
EGFR	GNLEITMCR	OESOPHAGUS	63	p.T68fs	c.203_203delC	Frame_Shift_Del	3	0.11	KYSE70	N	2	0	0	N
EGFR	GSLWRTLSA	LARGE_INTESTINE	547	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	3	0	0	Y
EGFR	ITMCRGIMI	OESOPHAGUS	67	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	Y	9	15	8	N
EGFR	KCNLLEVSQ	LARGE_INTESTINE	538	p.E543fs	c.1629_1629delG	Frame_Shift_Del	3	0.11	CW2	N	0	0	0	N
EGFR	LEITMCRGI	OESOPHAGUS	65	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	8	0	7	N
EGFR	LEVSQGSLW	LARGE_INTESTINE	542	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	8	0	0	N
EGFR	LGNLEITMC	OESOPHAGUS	62	p.T68fs	c.203_203delC	Frame_Shift_Del	2	0.11	KYSE70	N	0	0	3	N
EGFR	LLEVSQGSL	LARGE_INTESTINE	541	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	9	0	0	N
EGFR	LSAYSATQS	LARGE_INTESTINE	553	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	0	0	1	N
EGFR	LWRTLSAYS	LARGE_INTESTINE	549	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	0	0	4	Y
EGFR	MCRGIMIFP	OESOPHAGUS	69	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	N	0	0	0	N
EGFR	NLEITMCRG	OESOPHAGUS	64	p.T68fs	c.203_203delC	Frame_Shift_Del	4	0.11	KYSE70	N	1	0	0	N
EGFR	NLLEVSQGS	LARGE_INTESTINE	540	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	0	0	0	N
EGFR	QGSLWRTLS	LARGE_INTESTINE	546	p.E543fs	c.1629_1629delG	Frame_Shift_Del	6	0.11	CW2	N	0	0	0	Y
EGFR	RTLSAYSAT	LARGE_INTESTINE	551	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	2	0	0	N
EGFR	SATQSACLR	LARGE_INTESTINE	557	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	3	0	0	N
EGFR	SAYSATQSA	LARGE_INTESTINE	554	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	4	0	0	N
EGFR	SLWRTLSAY	LARGE_INTESTINE	548	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	Y	7	15	0	Y
EGFR	SQGSLWRTL	LARGE_INTESTINE	545	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	Y	8	12	0	N
EGFR	TLSAYSATQ	LARGE_INTESTINE	552	p.E543fs	c.1629_1629delG	Frame_Shift_Del	4	0.11	CW2	N	1	0	0	N
EGFR	TMCRGIMIF	OESOPHAGUS	68	p.T68fs	c.203_203delC	Frame_Shift_Del	5	0.11	KYSE70	Y	6	9	0	N
EGFR	VDKCNLLEV	LARGE_INTESTINE	536	p.E543fs	c.1629_1629delG	Frame_Shift_Del	1	0.11	CW2	N	5	0	0	N
EGFR	VLGNLEITM	OESOPHAGUS	61	p.T68fs	c.203_203delC	Frame_Shift_Del	1	0.11	KYSE70	N	6	0	0	N
EGFR	VSQGSLWRT	LARGE_INTESTINE	544	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	1	0	0	Y
EGFR	WRTLSAYSA	LARGE_INTESTINE	550	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	5	0	24	N
EGFR	YSATQSACL	LARGE_INTESTINE	556	p.E543fs	c.1629_1629delG	Frame_Shift_Del	5	0.11	CW2	N	11	0	2	N
EGFR	AAACTGPRE	LIVER	237	p.G239A	c.716G>C	Missense_Mutation	1	0.11	SNU886	N	0	0	0	N
EGFR	AACTGPRES	LIVER	238	p.G239A	c.716G>C	Missense_Mutation	1	0.11	SNU886	N	1	0	0	N
EGFR	ACTGPRESD	LIVER	239	p.G239A	c.716G>C	Missense_Mutation	1	0.11	SNU886	N	0	0	0	N
EGFR	AFGADSYEM	LUNG	310	p.C311F	c.932G>T	Missense_Mutation	1	0.11	NCIH1793	N	2	0	0	N
EGFR	AGEENCQNL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	202	p.K209N	c.627A>C	Missense_Mutation	1	0.11	AMO1	Y	11	9	0	N
EGFR	AHKGSHQIS	LUNG	1158	p.Q1159H	c.3477G>C	Missense_Mutation	1	0.11	NCIH1355	N	1	0	0	N
EGFR	AHWAHKGSH	LUNG	1155	p.Q1159H	c.3477G>C	Missense_Mutation	1	0.11	NCIH1355	N	0	0	0	N
EGFR	AIDVYMIMV	LARGE_INTESTINE	940	p.T940A	c.2818A>G	Missense_Mutation	1	0.11	LS411N	Y	7	10	0	N
EGFR	AIKELREAI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	743	p.T751I	c.2252C>T	Missense_Mutation	1	0.11	RPMI8226	N	4	0	0	N
EGFR	AISPKANKE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	750	p.T751I	c.2252C>T	Missense_Mutation	1	0.11	RPMI8226	N	0	0	0	N
EGFR	AIVDNPHVC	OESOPHAGUS	767	p.S768I	c.2303G>T	Missense_Mutation	1	0.11	KYSE450	N	2	0	0	N
EGFR	AKLLGVEEK	LARGE_INTESTINE	859	p.A864V	c.2591C>T	Missense_Mutation	1	0.11	SNU175	Y	1	17	0	N
EGFR	ALNTVEQIP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	92	p.R98Q	c.293G>A	Missense_Mutation	1	0.11	SUDHL1	N	0	0	0	N
EGFR	ANKKILDEA	SKIN	755	p.E758K	c.2272G>A	Missense_Mutation	1	0.11	WM88	N	0	0	0	N
EGFR	APSRDPQYQ	OVARY	1118	p.H1124Q	c.3372C>G	Missense_Mutation	1	0.11	COV362	N	0	0	0	N
EGFR	AQDPQRYLV	ENDOMETRIUM	972	p.R973Q	c.2918G>A	Missense_Mutation	1	0.11	ISHIKAWAHERAKLIO02ER	Y	6	13	0	N
EGFR	ASEISSILG	LARGE_INTESTINE	920	p.E928G	c.2783A>G	Missense_Mutation	1	0.11	CW2	N	1	0	0	N