Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDH1 | APRPIRPPF | LARGE_INTESTINE | 124 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | Y | 12 | 10 | 0 | N | ||||||||||||
| CDH1 | GTTTAPRPI | LARGE_INTESTINE | 120 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 2 | 0 | 0 | N | ||||||||||||
| CDH1 | KVTLNTVGT | LARGE_INTESTINE | 113 | p.V119fs | c.357_357delG | Frame_Shift_Del | 1 | 0.11 | HCT116 | N | 3 | 0 | 0 | N | ||||||||||||
| CDH1 | LNTVGTTTA | LARGE_INTESTINE | 116 | p.V119fs | c.357_357delG | Frame_Shift_Del | 4 | 0.11 | HCT116 | N | 2 | 0 | 6 | N | ||||||||||||
| CDH1 | NTVGTTTAP | LARGE_INTESTINE | 117 | p.V119fs | c.357_357delG | Frame_Shift_Del | 4 | 0.11 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | TAPRPIRPP | LARGE_INTESTINE | 123 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | TLNTVGTTT | LARGE_INTESTINE | 115 | p.V119fs | c.357_357delG | Frame_Shift_Del | 3 | 0.11 | HCT116 | N | 2 | 0 | 0 | N | ||||||||||||
| CDH1 | TTAPRPIRP | LARGE_INTESTINE | 122 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | Y | 0 | 12 | 0 | N | ||||||||||||
| CDH1 | TTTAPRPIR | LARGE_INTESTINE | 121 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 4 | 0 | 0 | N | ||||||||||||
| CDH1 | TVGTTTAPR | LARGE_INTESTINE | 118 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | Y | 5 | 9 | 0 | Y | ||||||||||||
| CDH1 | VGTTTAPRP | LARGE_INTESTINE | 119 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | VTLNTVGTT | LARGE_INTESTINE | 114 | p.V119fs | c.357_357delG | Frame_Shift_Del | 2 | 0.11 | HCT116 | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | GHHHRPRPI | LARGE_INTESTINE | 120 | p.R124fs | c.372_372delC | Frame_Shift_Del | 2 | 0.22 | GP2D | N | 5 | 0 | 0 | N | ||||||||||||
| CDH1 | GHHHRPRPI | STOMACH | 120 | p.R124fs | c.372_372delC | Frame_Shift_Del | 2 | 0.22 | IM95 | N | 5 | 0 | 0 | N | ||||||||||||
| CDH1 | HHHRPRPIR | LARGE_INTESTINE | 121 | p.R124fs | c.372_372delC | Frame_Shift_Del | 3 | 0.22 | GP2D | Y | 2 | 9 | 0 | N | ||||||||||||
| CDH1 | HHHRPRPIR | STOMACH | 121 | p.R124fs | c.372_372delC | Frame_Shift_Del | 3 | 0.22 | IM95 | Y | 2 | 9 | 0 | N | ||||||||||||
| CDH1 | HHRPRPIRP | LARGE_INTESTINE | 122 | p.R124fs | c.372_372delC | Frame_Shift_Del | 4 | 0.22 | GP2D | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | HHRPRPIRP | STOMACH | 122 | p.R124fs | c.372_372delC | Frame_Shift_Del | 4 | 0.22 | IM95 | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | HRPRPIRPP | LARGE_INTESTINE | 123 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.22 | GP2D | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | HRPRPIRPP | STOMACH | 123 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.22 | IM95 | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | RPRPIRPPF | LARGE_INTESTINE | 124 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.22 | GP2D | Y | 14 | 12 | 0 | N | ||||||||||||
| CDH1 | RPRPIRPPF | STOMACH | 124 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.22 | IM95 | Y | 14 | 12 | 0 | N | ||||||||||||
| CDH1 | TVGHHHRPR | LARGE_INTESTINE | 118 | p.R124fs | c.372_372delC | Frame_Shift_Del | 1 | 0.22 | GP2D | Y | 3 | 9 | 0 | N | ||||||||||||
| CDH1 | TVGHHHRPR | STOMACH | 118 | p.R124fs | c.372_372delC | Frame_Shift_Del | 1 | 0.22 | IM95 | Y | 3 | 9 | 0 | N | ||||||||||||
| CDH1 | VGHHHRPRP | LARGE_INTESTINE | 119 | p.R124fs | c.372_372delC | Frame_Shift_Del | 1 | 0.22 | GP2D | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | VGHHHRPRP | STOMACH | 119 | p.R124fs | c.372_372delC | Frame_Shift_Del | 1 | 0.22 | IM95 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | AAQKMKKAH | LARGE_INTESTINE | 162 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | GP2D | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | AAQKMKKAH | LARGE_INTESTINE | 162 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.33 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | AAQKMKKAH | STOMACH | 162 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | IM95 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | AHFLKTWFR | LARGE_INTESTINE | 169 | p.R124fs | c.372_372delC | Frame_Shift_Del | 6 | 0.33 | GP2D | N | 2 | 0 | 0 | N | ||||||||||||
| CDH1 | AHFLKTWFR | LARGE_INTESTINE | 169 | p.V119fs | c.357_357delG | Frame_Shift_Del | 6 | 0.33 | HCT116 | N | 2 | 0 | 0 | N | ||||||||||||
| CDH1 | AHFLKTWFR | STOMACH | 169 | p.R124fs | c.372_372delC | Frame_Shift_Del | 6 | 0.33 | IM95 | N | 2 | 0 | 0 | N | ||||||||||||
| CDH1 | AKELTHPLL | LARGE_INTESTINE | 194 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | GP2D | N | 4 | 0 | 0 | N | ||||||||||||
| CDH1 | AKELTHPLL | LARGE_INTESTINE | 194 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.33 | HCT116 | N | 4 | 0 | 0 | N | ||||||||||||
| CDH1 | AKELTHPLL | STOMACH | 194 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | IM95 | N | 4 | 0 | 0 | N | ||||||||||||
| CDH1 | AQKMKKAHF | LARGE_INTESTINE | 163 | p.R124fs | c.372_372delC | Frame_Shift_Del | 6 | 0.33 | GP2D | N | 7 | 0 | 0 | N | ||||||||||||
| CDH1 | AQKMKKAHF | LARGE_INTESTINE | 163 | p.V119fs | c.357_357delG | Frame_Shift_Del | 6 | 0.33 | HCT116 | N | 7 | 0 | 0 | N | ||||||||||||
| CDH1 | AQKMKKAHF | STOMACH | 163 | p.R124fs | c.372_372delC | Frame_Shift_Del | 6 | 0.33 | IM95 | N | 7 | 0 | 0 | N | ||||||||||||
| CDH1 | ARFSTASLA | LARGE_INTESTINE | 186 | p.R124fs | c.372_372delC | Frame_Shift_Del | 6 | 0.33 | GP2D | Y | 5 | 9 | 0 | N | ||||||||||||
| CDH1 | ARFSTASLA | LARGE_INTESTINE | 186 | p.V119fs | c.357_357delG | Frame_Shift_Del | 6 | 0.33 | HCT116 | Y | 5 | 9 | 0 | N | ||||||||||||
| CDH1 | ARFSTASLA | STOMACH | 186 | p.R124fs | c.372_372delC | Frame_Shift_Del | 6 | 0.33 | IM95 | Y | 5 | 9 | 0 | N | ||||||||||||
| CDH1 | ASEDRRETG | LARGE_INTESTINE | 148 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | GP2D | Y | 1 | 11 | 0 | N | ||||||||||||
| CDH1 | ASEDRRETG | LARGE_INTESTINE | 148 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.33 | HCT116 | Y | 1 | 11 | 0 | N | ||||||||||||
| CDH1 | ASEDRRETG | STOMACH | 148 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | IM95 | Y | 1 | 11 | 0 | N | ||||||||||||
| CDH1 | ASLAKELTH | LARGE_INTESTINE | 191 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | GP2D | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | ASLAKELTH | LARGE_INTESTINE | 191 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.33 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | ASLAKELTH | STOMACH | 191 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | IM95 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | CSHFPTPLL | LARGE_INTESTINE | 139 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | GP2D | Y | 11 | 10 | 0 | N | ||||||||||||
| CDH1 | CSHFPTPLL | LARGE_INTESTINE | 139 | p.V119fs | c.357_357delG | Frame_Shift_Del | 5 | 0.33 | HCT116 | Y | 11 | 10 | 0 | N | ||||||||||||
| CDH1 | CSHFPTPLL | STOMACH | 139 | p.R124fs | c.372_372delC | Frame_Shift_Del | 5 | 0.33 | IM95 | Y | 11 | 10 | 0 | N | ||||||||||||
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