Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
BRAF	ATPLPHYLA	ENDOMETRIUM	400	p.P403fs	c.1208_1208delC	Frame_Shift_Del	6	0.22	ISHIKAWAHERAKLIO02ER	N	2	0	0	N
BRAF	ATPLPHYLA	ENDOMETRIUM	400	p.P403fs	c.1208_1208delC	Frame_Shift_Del	6	0.22	RL952	N	2	0	0	N
BRAF	GLSATPLPH	ENDOMETRIUM	397	p.P403fs	c.1208_1208delC	Frame_Shift_Del	3	0.22	ISHIKAWAHERAKLIO02ER	N	1	0	0	N
BRAF	GLSATPLPH	ENDOMETRIUM	397	p.P403fs	c.1208_1208delC	Frame_Shift_Del	3	0.22	RL952	N	1	0	0	N
BRAF	LSATPLPHY	ENDOMETRIUM	398	p.P403fs	c.1208_1208delC	Frame_Shift_Del	4	0.22	ISHIKAWAHERAKLIO02ER	N	8	0	0	N
BRAF	LSATPLPHY	ENDOMETRIUM	398	p.P403fs	c.1208_1208delC	Frame_Shift_Del	4	0.22	RL952	N	8	0	0	N
BRAF	SATPLPHYL	ENDOMETRIUM	399	p.P403fs	c.1208_1208delC	Frame_Shift_Del	5	0.22	ISHIKAWAHERAKLIO02ER	Y	12	10	0	N
BRAF	SATPLPHYL	ENDOMETRIUM	399	p.P403fs	c.1208_1208delC	Frame_Shift_Del	5	0.22	RL952	Y	12	10	0	N
BRAF	TGLSATPLP	ENDOMETRIUM	396	p.P403fs	c.1208_1208delC	Frame_Shift_Del	2	0.22	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
BRAF	TGLSATPLP	ENDOMETRIUM	396	p.P403fs	c.1208_1208delC	Frame_Shift_Del	2	0.22	RL952	N	0	0	0	N
BRAF	TPLPHYLAH	ENDOMETRIUM	401	p.P403fs	c.1208_1208delC	Frame_Shift_Del	6	0.22	ISHIKAWAHERAKLIO02ER	N	0	0	0	N
BRAF	TPLPHYLAH	ENDOMETRIUM	401	p.P403fs	c.1208_1208delC	Frame_Shift_Del	6	0.22	RL952	N	0	0	0	N
BRAF	TTGLSATPL	ENDOMETRIUM	395	p.P403fs	c.1208_1208delC	Frame_Shift_Del	1	0.22	ISHIKAWAHERAKLIO02ER	N	4	0	0	N
BRAF	TTGLSATPL	ENDOMETRIUM	395	p.P403fs	c.1208_1208delC	Frame_Shift_Del	1	0.22	RL952	N	4	0	0	N
BRAF	ADEDHQNQF	LARGE_INTESTINE	349	p.R354Q	c.1061G>A	Missense_Mutation	1	0.11	HT115	N	2	0	0	Y
BRAF	AFTNEVGVL	ENDOMETRIUM	497	p.K499T	c.1496A>C	Missense_Mutation	1	0.11	JHUEM7	N	5	0	0	N
BRAF	AIVAQWCEG	LARGE_INTESTINE	526	p.T529A	c.1585A>G	Missense_Mutation	1	0.11	GP2D	N	0	0	0	N
BRAF	APSIYLEAY	BREAST	74	p.P74A	c.220C>G	Missense_Mutation	1	0.11	MDAMB415	N	10	0	0	N
BRAF	AQSNPKSPQ	CENTRAL_NERVOUS_SYSTEM	145	p.R146Q	c.437G>A	Missense_Mutation	1	0.11	CCFSTTG1	N	0	0	0	N
BRAF	AQWCEGSSL	LARGE_INTESTINE	529	p.T529A	c.1585A>G	Missense_Mutation	1	0.11	GP2D	N	12	0	0	N
BRAF	ARSLPKIHC	LARGE_INTESTINE	718	p.R726C	c.2176C>T	Missense_Mutation	1	0.11	SNU407	N	2	0	0	N
BRAF	ASMDSVTSS	LARGE_INTESTINE	115	p.T119S	c.356C>G	Missense_Mutation	1	0.11	HT29	N	1	0	0	N
BRAF	ATKKSRWSG	LARGE_INTESTINE	598	p.V600K	c.1798_1799GT>AA	Missense_Mutation	1	0.11	MDST8	N	0	0	0	N
BRAF	ATVYKGKWH	LUNG	469	p.G469A	c.1406G>C	Missense_Mutation	1	0.11	NCIH1755	N	0	0	0	N
BRAF	AVKMWNVTA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	481	p.L485W	c.1454T>G	Missense_Mutation	1	0.11	CI1	Y	1	11	0	N
BRAF	CNTEVPLMC	LARGE_INTESTINE	272	p.S273N	c.818G>A	Missense_Mutation	1	0.11	CCK81	N	0	0	0	N
BRAF	CSASEPSLN	LARGE_INTESTINE	726	p.R726C	c.2176C>T	Missense_Mutation	1	0.11	SNU407	N	0	0	0	N
BRAF	CSTKVPLMC	SKIN	272	p.E275K	c.823G>A	Missense_Mutation	1	0.11	SKMEL30	N	1	0	0	N
BRAF	CVNYDQLHL	SKIN	280	p.D287H	c.859G>C	Missense_Mutation	1	0.11	SKMEL30	N	5	0	0	N
BRAF	DEDHQNQFG	LARGE_INTESTINE	350	p.R354Q	c.1061G>A	Missense_Mutation	1	0.11	HT115	N	0	0	0	N
BRAF	DFGLATKKS	LARGE_INTESTINE	594	p.V600K	c.1798_1799GT>AA	Missense_Mutation	1	0.11	MDST8	N	0	0	0	N
BRAF	DFGRATVKS	PROSTATE	594	p.L597R	c.1790T>G	Missense_Mutation	1	0.11	22RV1	N	0	0	0	N
BRAF	DFGVATVKS	LUNG	594	p.L597V	c.1789C>G	Missense_Mutation	1	0.11	NCIH2087	N	0	0	0	N
BRAF	DFRLATVKS	LARGE_INTESTINE	594	p.G596R	c.1786G>C	Missense_Mutation	1	0.11	NCIH508	N	0	0	0	N
BRAF	DFSLYVCAS	OVARY	742	p.A747V	c.2240C>T	Missense_Mutation	1	0.11	OC316	N	0	0	0	N
BRAF	DGEKKPVGW	SKIN	202	p.I208V	c.622A>G	Missense_Mutation	1	0.11	LOXIMVI	N	2	0	0	Y
BRAF	DHQNQFGQR	LARGE_INTESTINE	352	p.R354Q	c.1061G>A	Missense_Mutation	1	0.11	HT115	N	1	0	0	Y
BRAF	DKFGGEHNA	BREAST	66	p.P74A	c.220C>G	Missense_Mutation	1	0.11	MDAMB415	N	1	0	0	N
BRAF	DLKSNKIFL	SKIN	576	p.N581K	c.1743T>A	Missense_Mutation	1	0.11	HS936T	Y	9	11	0	N
BRAF	DLKSNYIFL	LARGE_INTESTINE	576	p.N581Y	c.1741A>T	Missense_Mutation	1	0.11	HT55	Y	8	10	0	N
BRAF	DLSKVRNNC	LUNG	677	p.S683N	c.2048G>A	Missense_Mutation	1	0.11	SW1271	Y	1	9	0	N
BRAF	DPVNIDDLI	LUNG	375	p.E375D	c.1125A>T	Missense_Mutation	1	0.11	NCIH1651	N	14	0	0	N
BRAF	DQLHLLFVS	SKIN	284	p.D287H	c.859G>C	Missense_Mutation	1	0.11	SKMEL30	N	1	0	0	N
BRAF	DSNRMKTLG	LUNG	434	p.R435S	c.1305G>T	Missense_Mutation	1	0.11	RERFLCAD1	N	0	0	0	N
BRAF	DSVTSSSSS	LARGE_INTESTINE	118	p.T119S	c.356C>G	Missense_Mutation	1	0.11	HT29	N	1	0	0	N
BRAF	DVAQSNPKS	CENTRAL_NERVOUS_SYSTEM	143	p.R146Q	c.437G>A	Missense_Mutation	1	0.11	CCFSTTG1	N	1	0	0	N
BRAF	DVAVKMWNV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	479	p.L485W	c.1454T>G	Missense_Mutation	1	0.11	CI1	Y	4	11	0	N
BRAF	EDFSLYVCA	OVARY	741	p.A747V	c.2240C>T	Missense_Mutation	1	0.11	OC316	N	8	0	0	N
BRAF	EDHQNQFGQ	LARGE_INTESTINE	351	p.R354Q	c.1061G>A	Missense_Mutation	1	0.11	HT115	N	0	0	0	N
BRAF	EDSNRMKTL	LUNG	433	p.R435S	c.1305G>T	Missense_Mutation	1	0.11	RERFLCAD1	Y	7	9	0	N