Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKAP12 | APKFKFRAL | ENDOMETRIUM | 1407 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | Y | 16 | 12 | 0 | N | ||||||||||||
| AKAP12 | CLGQERQYA | ENDOMETRIUM | 1399 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 4 | 0.11 | EN | N | 2 | 0 | 0 | N | ||||||||||||
| AKAP12 | ERQYAPKFK | ENDOMETRIUM | 1403 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | N | 1 | 0 | 0 | Y | ||||||||||||
| AKAP12 | FKFRALRHH | ENDOMETRIUM | 1410 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | N | 3 | 0 | 17 | N | ||||||||||||
| AKAP12 | FRALRHHSL | ENDOMETRIUM | 1412 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | Y | 9 | 10 | 17 | N | ||||||||||||
| AKAP12 | GQERQYAPK | ENDOMETRIUM | 1401 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | N | 4 | 0 | 0 | N | ||||||||||||
| AKAP12 | KFKFRALRH | ENDOMETRIUM | 1409 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | Y | 1 | 14 | 0 | N | ||||||||||||
| AKAP12 | KFRALRHHS | ENDOMETRIUM | 1411 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 4 | 0.11 | EN | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | KNQSPSWKR | ENDOMETRIUM | 770 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 3 | 0 | 0 | N | ||||||||||||
| AKAP12 | KRLVTPRKN | ENDOMETRIUM | 763 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 1 | 0.11 | HEC108 | N | 2 | 0 | 0 | N | ||||||||||||
| AKAP12 | KVLSKPPKA | LARGE_INTESTINE | 487 | p.P492fs | c.1474_1474delC | Frame_Shift_Del | 2 | 0.11 | SNUC2A | N | 5 | 0 | 0 | N | ||||||||||||
| AKAP12 | LGQERQYAP | ENDOMETRIUM | 1400 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | LVTPRKNQS | ENDOMETRIUM | 765 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 3 | 0.11 | HEC108 | N | 0 | 0 | 21 | N | ||||||||||||
| AKAP12 | NQSPSWKRK | ENDOMETRIUM | 771 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | Y | 3 | 13 | 0 | N | ||||||||||||
| AKAP12 | PCLGQERQY | ENDOMETRIUM | 1398 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 3 | 0.11 | EN | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | PKFKFRALR | ENDOMETRIUM | 1408 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | PPCLGQERQ | ENDOMETRIUM | 1397 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 2 | 0.11 | EN | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | PPPCLGQER | ENDOMETRIUM | 1396 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 1 | 0.11 | EN | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | PRKNQSPSW | ENDOMETRIUM | 768 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | PSWKRKAKT | ENDOMETRIUM | 774 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | QERQYAPKF | ENDOMETRIUM | 1402 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 5 | 0.11 | EN | N | 5 | 0 | 0 | N | ||||||||||||
| AKAP12 | QSPSWKRKA | ENDOMETRIUM | 772 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | QYAPKFKFR | ENDOMETRIUM | 1405 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 6 | 0.11 | EN | Y | 2 | 11 | 0 | N | ||||||||||||
| AKAP12 | RKNQSPSWK | ENDOMETRIUM | 769 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | RLVTPRKNQ | ENDOMETRIUM | 764 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 2 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | RQYAPKFKF | ENDOMETRIUM | 1404 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 6 | 0.11 | EN | N | 12 | 0 | 0 | N | ||||||||||||
| AKAP12 | SPSWKRKAK | ENDOMETRIUM | 773 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | Y | 1 | 10 | 0 | N | ||||||||||||
| AKAP12 | SWKRKAKTP | ENDOMETRIUM | 775 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 4 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | TPRKNQSPS | ENDOMETRIUM | 767 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 5 | 0 | 0 | N | ||||||||||||
| AKAP12 | VLSKPPKAL | LARGE_INTESTINE | 488 | p.P492fs | c.1474_1474delC | Frame_Shift_Del | 3 | 0.11 | SNUC2A | N | 9 | 0 | 5 | N | ||||||||||||
| AKAP12 | VTPRKNQSP | ENDOMETRIUM | 766 | p.R769fs | c.2307_2307delA | Frame_Shift_Del | 4 | 0.11 | HEC108 | N | 0 | 0 | 1 | N | ||||||||||||
| AKAP12 | YAPKFKFRA | ENDOMETRIUM | 1406 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 6 | 0.11 | EN | N | 8 | 0 | 12 | N | ||||||||||||
| AKAP12 | EKVLSKPPK | LARGE_INTESTINE | 486 | p.P492fs | c.1474_1474delC | Frame_Shift_Del | 1 | 0.22 | SNUC2A | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | ASGTQSGGH | LARGE_INTESTINE | 1201 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 1 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | ASSTFQFCV | LARGE_INTESTINE | 1221 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 6 | 0 | 0 | Y | ||||||||||||
| AKAP12 | CTEREASST | LARGE_INTESTINE | 1216 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 4 | 0.11 | RKO | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | EASSTFQFC | LARGE_INTESTINE | 1220 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 2 | 0 | 0 | Y | ||||||||||||
| AKAP12 | EREASSTFQ | LARGE_INTESTINE | 1218 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | FQFCVPGRN | LARGE_INTESTINE | 1225 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 6 | 0.11 | RKO | N | 4 | 0 | 5 | N | ||||||||||||
| AKAP12 | GGHRSRGSS | LARGE_INTESTINE | 1207 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | GHRSRGSSC | LARGE_INTESTINE | 1208 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | GSSCTEREA | LARGE_INTESTINE | 1213 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 4 | 0.11 | RKO | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | GTQSGGHRS | LARGE_INTESTINE | 1203 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 3 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | HRSRGSSCT | LARGE_INTESTINE | 1209 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 2 | 0 | 0 | N | ||||||||||||
| AKAP12 | QSGGHRSRG | LARGE_INTESTINE | 1205 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | REASSTFQF | LARGE_INTESTINE | 1219 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | Y | 10 | 10 | 0 | Y | ||||||||||||
| AKAP12 | RGSSCTERE | LARGE_INTESTINE | 1212 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 4 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | RSRGSSCTE | LARGE_INTESTINE | 1210 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 4 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | SCTEREASS | LARGE_INTESTINE | 1215 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 4 | 0.11 | RKO | N | 1 | 0 | 0 | N | ||||||||||||
| AKAP12 | SGGHRSRGS | LARGE_INTESTINE | 1206 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 5 | 0.11 | RKO | N | 1 | 0 | 0 | N | ||||||||||||
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