Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AAK1 | AQFQMYRTL | LARGE_INTESTINE | 319 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | Y | 15 | 9 | 0 | N | ||||||||||||
| AAK1 | FSLSYSRKS | LARGE_INTESTINE | 310 | p.S311fs | c.933_933delA | Frame_Shift_Del | 6 | 0.11 | SW403 | N | 2 | 0 | 8 | N | ||||||||||||
| AAK1 | KSAQFQMYR | LARGE_INTESTINE | 317 | p.S311fs | c.933_933delA | Frame_Shift_Del | 6 | 0.11 | SW403 | Y | 5 | 9 | 0 | N | ||||||||||||
| AAK1 | LPFLQSFLN | LARGE_INTESTINE | 327 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 7 | 0 | 1 | N | ||||||||||||
| AAK1 | LSYSRKSAQ | LARGE_INTESTINE | 312 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 0 | 0 | 6 | N | ||||||||||||
| AAK1 | PFLQSFLNQ | LARGE_INTESTINE | 328 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 0 | 0 | 0 | N | ||||||||||||
| AAK1 | QFQMYRTLP | LARGE_INTESTINE | 320 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 0 | 0 | 0 | N | ||||||||||||
| AAK1 | RKSAQFQMY | LARGE_INTESTINE | 316 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 3 | 0 | 0 | N | ||||||||||||
| AAK1 | SAQFQMYRT | LARGE_INTESTINE | 318 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 3 | 0 | 0 | N | ||||||||||||
| AAK1 | SLSYSRKSA | LARGE_INTESTINE | 311 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 2 | 0 | 0 | N | ||||||||||||
| AAK1 | SRKSAQFQM | LARGE_INTESTINE | 315 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | Y | 3 | 9 | 0 | N | ||||||||||||
| AAK1 | SYFSLSYSR | LARGE_INTESTINE | 308 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 3 | 0 | 0 | N | ||||||||||||
| AAK1 | SYSRKSAQF | LARGE_INTESTINE | 313 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | Y | 4 | 10 | 0 | N | ||||||||||||
| AAK1 | YFSLSYSRK | LARGE_INTESTINE | 309 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | Y | 3 | 13 | 2 | N | ||||||||||||
| AAK1 | YSRKSAQFQ | LARGE_INTESTINE | 314 | p.S311fs | c.933_933delA | Frame_Shift_Del | 5 | 0.11 | SW403 | N | 2 | 0 | 6 | N | ||||||||||||
| AAK1 | EFAPHSNLC | LARGE_INTESTINE | 881 | p.P884fs | c.2652_2653insC | Frame_Shift_Ins | 5 | 0.11 | LS180 | N | 1 | 0 | 0 | N | ||||||||||||
| AAK1 | PHSNLCSSP | LARGE_INTESTINE | 884 | p.P884fs | c.2652_2653insC | Frame_Shift_Ins | 5 | 0.11 | LS180 | N | 0 | 0 | 0 | N | ||||||||||||
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