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The total number entries retrieved from this search are 20
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Note: Potential Biomarker with * indicates these signatures are candidate biomarkers extracted from experiments on mice, rat or cell lines and they are not validated on human patients'cohort.
Biomarker IDBiomarkerBiomoleculeSubjectRegulationBiomarker's typeExperimentLevel of significanceSourcePMID
2268LIMK1, CENPE, FZD2, ENO2, ITGA9, COPA, KIAA0660, GTF2H1, VPS41, RGS20, MATK, STOML1, BASP1, EPB42, ALDH3B2, MEL, CAT56, RAB3A, PSCD3, PLD2, ADCYAP1R1, ALDH3B1, RHD, CSF3R, KIAA0063, KIAA0296, LRP6, ENO3, CTRB1, YES1, IncytePD:1404153, GYS1, MDFI, GABRE, IncytePD:2685601, CD3Z, DTYMK, SPTBN2, IncytePRNAsHumanUpregulated in PT than PN (with 3 fold change) DiagnosticMetastatic HCC v/s Primary HCC p < 0.01Tissue12640447
2341ZNF216RNAsHumanDownregulated in HCCs with PVI in comparison with HCCs without PVI (with Fisher ratio 1.54) PrognosticHCC with PVI v/s HCC without PVI p < 0.05Tissue17088983
2360PARD3, INSIG1, MPHOSPH9, SKP2, CUL4B, CETN2, ETS2, USH1C, PTPN11, OASL, ARL5, SMURF2, CDC42SE1, CSNK1G3, RACGAP1, DNAJC10, KCNK1, CDO1, CNGA1, NUDT9, GSTM3, SLC16A5, SARA2, ID2, MTHFD2L, SYNGR2, PRL10A, RNF130, MAFB, FLJ23749, LARP6, R3HDM, ZNF652, PGGT1B, HEXB, SLC27A2, ZBTB38, SH3GLB2, AGPAT3, GCHRNAsHumanDifferentially expressed between recurrence HCC disease PrognosticRecurrent v/s non-recurrent HCC p < 0.05Tissue17975138
2419IGF2ProteinHumanUpregulated in HCC than normal DiagnosticHCC v/s normal (R2 = 0.85) compared with HCC versus normal liver (R2 = 0.51)Tissue14517841
2460MEF2BRNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.49) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2464EGR3, MFAP3, EST, MMP9, PDCD4, EST, FLJ37853, ARHE, MAD2L1, NMNAT2, FLJ22016, SND1, MIDORI, FLJ36229, MGST2, CTPS2, OASL, HK2, EEF2, Taxilin, NT5C, CLNS1A, UNC5B, TSC, TNFSF6, KIAA1691, S100A10, ATP6V1D, ASB4, AGR2, KIAA0205, JJAZ1, LOC285859, KIAA0157, PPA2, eIF3k, SGKL, BLMH, ERG-1, BRCA2, PPP2R2ARNAsHumanDifferentially expressed (14 Upregulated and 49 Downregulated) in treatment responder v/s non-responders Predictivetreatment responder v/s non-responders p < 0.01Tissue15447987
2484SOX6, ITIH4, HDGF, SKIP1, RBP4, LOC92033, UGT2B7, FABP1, GATM, UQCRC1, UK114, CP, PBEF, KAL1, CES2, GPX4, UGT1A4, RCL, PABPC1, EST, FGA, RARRES2, SLC22A, SRP14, FLJ14294, cyclin, CA2, CLDN1, FTL, FLJ10004, CYP3A5, ARHGEF12, TDO2, NDUFB2, TEGT, SPR, PCK2, MGC13114, EST, MTHFS, F2, FLJ22313, C9orf5, HRNAsHumanDifferentially expressed between HCC and normal tissues DiagnosticHCC v/s normal p < 0.01Tissue14642619
2499SEMA3F, DDX17, TNFAIP, PDGFRA, VIM, LAPTM5, CCND2, HLADRA, MEF2C, Staf50, SGK, REL,RNAsHumanDiffrenetially Expressed between recurrent and non-recurrent HCC PrognosticEarly intrahepatic recurrence and non-recurrence HCC p < 0.05Tissue12648972
2500RYBP, ATP1B3, TMC, ZNF567, GPR108, CD19, SPINK1, CDC2L6, RSRC1, METAP, GPC3, SNHG11, RY1, CRELD2, GLUL, SERPINB1, TRMT6, UNC13D, E4F1--E4F, SLC22A2, CNIH4, TK1, MAFB, PPP1CB, DNTTIP2, ARID4B, SMARCC2, PRO1386, TRIOBP, VARS, ITGA5, TERF1, PURA, TUBA1B, SNRPE, RRAGD, VWF, GLRX3, ILF2,RNAsHumanUpregulated in HCV related HCC than normal control (With 3-fold change) DiagnosticHCV related HCC v/s normal control p < 0.01Tissue19821982
2501NMNAT3, OASL, TMPRSS3, MFSD7, AEBP1, UBD, S100A4, C1orf151, CRIP1, ASCC3, ZNF271, ANXA4, NMI, UBE2L6, B2 M, HLA-F, PSMB9, TAP1, PSME2, IFI16, IFI27, ARHGAP9, RABGAP1L, TNK1, DEF6, BTN3A3, RPS6KA1, CD24, PARP10, APOL3, STAT, ANKRD10, CKB, H2AFZ, PSMB9, RARRES3, RGS10, TUBB, NOL3, CD7,RNAsHumanUpregulated in HCV related non-HCC than normal control (With 3-fold change) DiagnosticHCV related non-HCC v/s normal control p < 0.01Tissue19821982
2502CAPG, OCC-1, EED, RPLP0, RPLP0P2, AP1S2, RRAGD, PFDN4, CCDC104, C7orf28B, PSIP1, LPCAT1, FSCN3, RAB24, ZNF446, SEC11B, ZNF586, SCNM1, SF3A1, RUFY1, TRIM55, GOLGA4, GPATCH4, THOP1, TUBB2C, PHLDB3, FAM104A, FASTK, EIF2AK4, ZFP41, PRKRIP1, DSTN, PHIP, NUCKS1, TNRC8, CCDC132, EPRS, HIST1H4C, CDCA8,RNAsHumanUpregulated in HCV related HCC than HCV related non-HCC (With 3-fold change) DiagnosticHCV related HCC v/s HCV related non-HCC p < 0.01Tissue19821982
2519Alpha-2-plasmin inhibitor, SERPINF2ProteinHumanDownregulated in HCC than non-tumor (with 100 fold change) DiagnosticHCC v/s non-tumor p < 0.05Cell line, Tissue16980951
2531TRIM25, EIF2S3, CLECSF14, DXYS155E, T-cell receptor beta locus, GIF2H2, SPON2, VDAC2, SLC15A3, HBP1, PTPRC, FES, CDC5L, ITGB2, MPP1, NDUFA2, AHCYL1, CNP, SQLE, RPA3, LGALS1, HLA-DQA1 , STMN1, PCOLCE, LOC387680, DPT, SLK, IGBP1, SNRPG, Human-alpha1-antitrypsin gene (S variant) complete cds, SIAHBP1, RNAsHuman7 genes Downregulated i.e. CYP1A2, Human-alpha1-antitrypsin gene (S variant) complete cds, PCOLCE, CNP, DXYS155E, CLECSF14, TRIM25 and 29 get upregulated in Diagnostic and prognosticSingle nodular HCC group v/s multicentric HCC group; associated with multicentric recurrence p < 0.05Tissue16788756
2536AF147376, FLJ20084, LRP8, DKK2, AK027155, AK002039, PLSCR4, AK021998, ESDN, AKR7A2, MAP2K2, AL133075, APOL3, AK023559, GNRHR, COQ6, AF086143, FLJ14117, HUMCYT2A, D25272, M37712, KLK12, ZNF205, NM_001758, AK001102, KIAA0562, CIAO1, SRRM2, UBE1, FBXO10, AF113699, APOB, D86974, Z70704, SFRS2IP, WDFY1, RNAsHumanDiscriminating among early-stage samples (between LGDN, HGDN and G1) PrognosticDysplastic nodules of HCC v/s Edmondson grade 1 p < 0.001Tissue16175600
2538ILF2, BMI1, TAF9, RFX5, SSRP1, ZNF146, SREBF2, MAFG, CHD4, NR4A1, ESR1, ZNF238, FOSB, ID1, FOS, H2AFY, SNRPB, RPS7, MRPS14, HNRPU, SNRPD2, NCL, RPS10, RPL6, SFPQ, DIM1, MARS, SFRS9, RBM3, U2AF65, SFRS1, SNRPE, SF3B4, RDBP, SNRPF, RRM1, RPL38, HNRPH1, U5-116KD, RPLP1, OXA1L, ADPRT, PRKDC, SMC4L1, H2ARNAsHumanDifferentially Expressed in HCC Tumors than non-tumor (with fold change of 1.5) DiagnosticHCC v/s non-tumor p < 0.01Tissue15057898
2547FBN1, MEF2C, TNFAIP3, LAPTM5, TMSB4X, CUGBP2, HLA-DRA, REL, clone110298, LTBP2, TRIM22, HLA-DRBI, FOXF1, HLA-DQA, SDF1, DDX17, SGK, PDGFRA, F2R, HLADG, MTAP44, CTSK, VIM, ACVR1, ON/SPARC, SCYA3, ARHGEF6, CCND2, COL1A1, ITGB2/CD18, PTPRC, MKNK1, JUNB, EST, GATA6, FUT3, RDBP, E48, SEMA3F, COL6A3, GBAPRNAsHuman 11 genes (FUT3, RDBP, E48, SEMA3F, COL6A3, GBAP, FUT1, GCHFR, CYP2A, MLH1, EST) Upregulated and rest 35 genes downregulated in HCC with early IHR vs. HCC without recurrence PrognosticIntrahepatic recurrence v/s Non-recurrence p < 0.05Tissue15688398
2569H19 and IGF2RNAsHumanUpregulated in B-type HCC DiagnosticHBV-HCC vs HCV -HCC; associated with the progression of HCC p < 0.05Tissue12124323
2576IGF2RNAsHumanUpregulated in HBV-HCCs from patients with LC DiagnosticHBV-HCCs patients with LC (liver cirrhosis) vs without LC (liver cirrhosis) P< 0.05Tissue12771952
2584OAS2, ADH1A, FLJ20378, HSF2, PSME1, E2L6, UBE2L6, STAT1, LIM, FLN29, GABARAPL1,RNAsHumanDownregulated in G2 than G1 (with fisher ratio more than 1.7) Prognostic G1 (well differentiated) HCV-HCC v/s G2 (moderately differentiated) HCV-HCC; associated with invasion or metastsis P < 0.005Tissue15710396
2590MPV17, EST, GZMB, ITGA6, EST, CENPC1, EST, SPP1, RTF1, CYB5-M, P4HA2, DNMBP, EST, DNAJB4, PRH1, STK23, TCF2, POSTN, SPP1, WIZ, OSMR, EST, ILIA, CD44, EST, MUC6, MTHFD2, ANXA2, PCSK2, RBP1, EST, ITGA6, APRT, PDUM3, TPM2, RNASE3, OSMR, GRK1, SLC14A, FETUB, ANXA2P1, UGT2B15, EST, KIAA0703, AKAP10, AVPRRNAsHumanGenes associated with EHR of HCC PrognosticExtrahepatic recurrence (EHR) v/s Early intrahepatic recurrence (IHR) P< 0.05Tissue17016605

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