Biomarker ID 2360 |
| Detailed information | |
|---|---|
| CancerLivER ID | 2360 |
| Biomarker | PARD3, INSIG1, MPHOSPH9, SKP2, CUL4B, CETN2, ETS2, USH1C, PTPN11, OASL, ARL5, SMURF2, CDC42SE1, CSNK1G3, RACGAP1, DNAJC10, KCNK1, CDO1, CNGA1, NUDT9, GSTM3, SLC16A5, SARA2, ID2, MTHFD2L, SYNGR2, PRL10A, RNF130, MAFB, FLJ23749, LARP6, R3HDM, ZNF652, PGGT1B, HEXB, SLC27A2, ZBTB38, SH3GLB2, AGPAT3, GCH |
| Biomarker Name/Symbol (given in Publication) | 57 gene signature (PARD3, INSIG1, MPHOSPH9, SKP2, CUL4B, CETN2, ETS2, USH1C, PTPN11, OASL, ARL5, SMURF2, CDC42SE1, CSNK1G3, RACGAP1, DNAJC10, KCNK1, CDO1, CNGA1, NUDT9, GSTM3, SLC16A5, SARA2, ID2, MTHFD2L, SYNGR2, PRL10A, RNF130, MAFB, FLJ23749, LARP6, R3HDM, ZNF652, PGGT1B, HEXB, SLC27A2, ZBTB38, SH3GLB2, AGPAT3, GCH1, SPACA3, LOC159090, FLJ11016, LOC285550, NARG2, FAM33A, AS3MT, TIGD2, KIAA0676, LMBRD2, MARVELD) |
| Biomolecule | RNAs |
| Subject | Human |
| Degree of Validity | 57-gene signature could accurately stratify HCC patients with different risks of recurrence and validated on independent dataset |
| Experimental Condition | Recurrent v/s non-recurrent HCC |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Differentially expressed between recurrence HCC disease |
| Level of significance | p < 0.05 |
| Source | Tissue |
| PMID | 17975138 |
| Type of Biomarker | Prognostic |
| Pathway | cell growth and maintenance, DNA replication and cellular metabolism, transcription and protein processing, cellular signaling, transport, immune regulators, and apoptosis |
| Cohort | Cancerous and non-cancerous tissue from 80 HCC patients (recurrence status of 80 HCC patients divided into the duration of 6, 12, 18, and 35 months after hepatectomy resection; recurrent (n = 39) and nonrecurrent (n = 41)); Further randomly 48 patients used to study recurrence of HCC for patients wi |
| Sensitivity | 86% |
| Specificity | 82% |
| Accuracy | 84% |
| AUC | NA |
| Disease | Recurrent v/s non-recurrent HCC |
| Year of Publication | 2007 |
| Clinical trial | NO |
| Clinical trial (NCT Number) | NA |