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I-(Hyp)-VILPPLPIFG details

Primary information
ID	antitb_1630,
Name	26213786
N-Terminal modification	Callyaerins 6
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	12
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Inhibition Concentration	Mycobacterium Tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis H37Rv
Cell Line	IC90= 2 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	NA
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1631,
Name	26213786
N-Terminal modification	Callyaerins 6
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	12
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Inhibition Concentration	Mycobacterium Tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis H37Rv
Cell Line	MIC= 6 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	NA
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1632,
Name	26213786
N-Terminal modification	Callyaerins 6
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	12
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
In Vitro/ In vivo	in vitro on THP1 cell line
Cell Line	IC50= 30 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	THP-1 cell line
In vivo Model	50% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1633,
Name	26213786
N-Terminal modification	Callyaerins 6
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	12
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
In Vitro/ In vivo	in vitro on THP1 cell line
Cell Line	IC90= 50 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	THP-1 cell line
In vivo Model	90% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1634,
Name	26213786
N-Terminal modification	Callyaerins 6
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	12
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
In Vitro/ In vivo	in vitro on MRC-5 cell lines
Cell Line	IC50= 20 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	MRC-5 cell lines
In vivo Model	50% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1635,
Name	26213786
N-Terminal modification	Callyaerins 6
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	12
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
In Vitro/ In vivo	in vitro on MRC-5 cell lines
Cell Line	IC90 = 40 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	MRC-5 cell lines
In vivo Model	90% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1636,
Name	26213786
N-Terminal modification	Callyaerins 7
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	11
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Inhibition Concentration	Mycobacterium Tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis H37Rv
Cell Line	IC90 =5 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	NA
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1637,
Name	26213786
N-Terminal modification	Callyaerins 7
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	11
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Inhibition Concentration	Mycobacterium Tuberculosis
In Vitro/ In vivo	Mycobacterium tuberculosis H37Rv
Cell Line	MIC = 10 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	NA
In vivo Model	NA
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1638,
Name	26213786
N-Terminal modification	Callyaerins 7
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	11
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Cell Line	IC50= 5 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	THP-1 cell line
In vivo Model	50% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1639,
Name	26213786
N-Terminal modification	Callyaerins 7
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	11
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Cell Line	IC90 = 30Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	THP-1 cell line
In vivo Model	90% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1640,
Name	26213786
N-Terminal modification	Callyaerins 7
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	11
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Cell Line	IC50= 2 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	MRC-5 cell lines
In vivo Model	50% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),

Primary information
ID	antitb_1641,
Name	26213786
N-Terminal modification	Callyaerins 7
C-Terminal Modification	I-(Hyp)-VILPPLPIFG
Chemical Modification	Free
Linear/Cyclic	Amidation
Length	Hyp= Hydroxiproline, Residue 1-8 involved in cyclic bond formation
Chirality	Cyclic
Nature	11
Source	D
Origin	Cationic
Species	Natural
Strain	Derived from Callyspongia aerizusa
Cell Line	I90C = 6 Î¼g/ml
Inhibition Concentration	in vitro
Sequence	2015
Cytotoxicity	MRC-5 cell lines
In vivo Model	90% reduction in bacterial load
Lethal Dose	NA
Immune Responce	NA
Mechanism of Action	NA
Target	NA
Combination Therapy	NA
Other activities	NA
PMID	NA
Year of Publication	NA
Tertiary Structure (Technique)	Not Predicted),