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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 51
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1881Polydim-I AVAGEKLWLLPHLLKMLLTPTPFreeFreeNoneLinear22LAmphipathicNaturalIsolated from the venom of the Neotropical wasp Polybia dimorpha Mycobacterium abscessusMycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus)MIC = 60.8 μg/mL BothPeritoneal macrophages, J774 macrophages cells, human red blood cells Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice 2 mg/kg/mLW shows 90% reduction in bacterial loadNACell wall disruption Cell wallNoneNA201626930596