Primary information |
---|
ID | antitb_1001, |
Name | 26930596 |
N-Terminal modification | Polydim-I |
C-Terminal Modification | AVAGEKLWLLPHLLKMLLTPTP |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | None |
Chirality | Linear |
Nature | 22 |
Source | L |
Origin | Amphipathic |
Species | Natural |
Strain | Isolated from the venom of the Neotropical wasp Polybia dimorpha |
Inhibition Concentration | Mycobacterium abscessus subsp. massiliense |
In Vitro/ In vivo | Mycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus) |
Cell Line | MIC = 60.8 μg/mL |
Inhibition Concentration | Both |
Sequence | 2016 |
Cytotoxicity | Peritoneal macrophages, J774 macrophages cells, human red blood cells |
In vivo Model | Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load |
Lethal Dose | Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity |
Immune Responce | 6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice |
Mechanism of Action | 2 mg/kg/mLW shows 90% reduction in bacterial load |
Target | NA |
Combination Therapy | Cell wall disruption |
Other activities | Cell wall |
PMID | None |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |
Primary information |
---|
ID | antitb_1881, |
Name | 26930596 |
N-Terminal modification | Polydim-I |
C-Terminal Modification | AVAGEKLWLLPHLLKMLLTPTP |
Chemical Modification | Free |
Linear/Cyclic | Free |
Length | None |
Chirality | Linear |
Nature | 22 |
Source | L |
Origin | Amphipathic |
Species | Natural |
Strain | Isolated from the venom of the Neotropical wasp Polybia dimorpha |
Inhibition Concentration | Mycobacterium abscessus |
In Vitro/ In vivo | Mycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus) |
Cell Line | MIC = 60.8 μg/mL |
Inhibition Concentration | Both |
Sequence | 2016 |
Cytotoxicity | Peritoneal macrophages, J774 macrophages cells, human red blood cells |
In vivo Model | Treatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load |
Lethal Dose | Non-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity |
Immune Responce | 6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice |
Mechanism of Action | 2 mg/kg/mLW shows 90% reduction in bacterial load |
Target | NA |
Combination Therapy | Cell wall disruption |
Other activities | Cell wall |
PMID | None |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |