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AVAGEKLWLLPHLLKMLLTPTP details
Primary information
ID antitb_1001,
Name26930596
N-Terminal modificationPolydim-I
C-Terminal ModificationAVAGEKLWLLPHLLKMLLTPTP
Chemical ModificationFree
Linear/CyclicFree
LengthNone
ChiralityLinear
Nature22
SourceL
OriginAmphipathic
SpeciesNatural
StrainIsolated from the venom of the Neotropical wasp Polybia dimorpha
Inhibition ConcentrationMycobacterium abscessus subsp. massiliense
In Vitro/ In vivoMycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus)
Cell LineMIC = 60.8 μg/mL
Inhibition ConcentrationBoth
Sequence2016
CytotoxicityPeritoneal macrophages, J774 macrophages cells, human red blood cells
In vivo ModelTreatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load
Lethal DoseNon-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity
Immune Responce6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice
Mechanism of Action2 mg/kg/mLW shows 90% reduction in bacterial load
TargetNA
Combination TherapyCell wall disruption
Other activitiesCell wall
PMIDNone
Year of PublicationNA
Tertiary Structure
(Technique)
Not Predicted),
Primary information
ID antitb_1881,
Name26930596
N-Terminal modificationPolydim-I
C-Terminal ModificationAVAGEKLWLLPHLLKMLLTPTP
Chemical ModificationFree
Linear/CyclicFree
LengthNone
ChiralityLinear
Nature22
SourceL
OriginAmphipathic
SpeciesNatural
StrainIsolated from the venom of the Neotropical wasp Polybia dimorpha
Inhibition ConcentrationMycobacterium abscessus
In Vitro/ In vivoMycobacterium abscessus subsp. massiliense isolates GO 01, GO 06, GO 07, GO 08, GO 13, and GO 18, CRM0020 (Mycobacterium abscessus subsp. massiliense), and ATCC19977 (Mycobacterium abscessus subsp. abscessus)
Cell LineMIC = 60.8 μg/mL
Inhibition ConcentrationBoth
Sequence2016
CytotoxicityPeritoneal macrophages, J774 macrophages cells, human red blood cells
In vivo ModelTreatment of infected macrophages with 7.6 μg/mL of Polydim-I decreased approximately 50% of the bacterial load
Lethal DoseNon-cytotoxic, 10% cytotoxicity on J774 cells at concentrations above 121.6 μg/mL (10%) and concentrations up to 121.6 μg/mL presented less than 2.5% of hemolytic activity
Immune Responce6 to 8 weeks old BALB/c and IFN-γKO (Knockout) female mice
Mechanism of Action2 mg/kg/mLW shows 90% reduction in bacterial load
TargetNA
Combination TherapyCell wall disruption
Other activitiesCell wall
PMIDNone
Year of PublicationNA
Tertiary Structure
(Technique)
Not Predicted),