Browse result page of TopicalPdb


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ID1622SequencepyroGHWSYlRP-NHEtNameLeuprolideNature of peptide or cargoNot mentionedAssayHPLCTissue permeability5 mg/mLTissue Samplehuman skin from tummy-tuck surgery (when available) or frozen skin from skin banksPUBMED ID2118954
ID1624SequencepyroGHWSYlRP-NHEtNameLeuprolide (Lupron)Nature of peptide or cargoIt is a useful model peptide for evaluating transdermal administration of peptide drugs.AssayAmerlex LH RIA kitTissue permeability From the transdermal route the peak response was 76.9 ± 99.8 mIU/ mlTissue SampleHuman skinPUBMED ID2121407
ID1625SequencePyroGlu-HWSYGLRPGNameGnRH (gonadotropin releasing hormone)Nature of peptide or cargoGonadotropin releasing hormoneAssayHPLCTissue permeabilityConcentration of GnRH in the receptor after 1 hour was 4,2 uM and after 4 hrs was 6,4 uM.Tissue SampleHairless mouse skinPUBMED ID2203894
ID1638SequencepyroGHWSYlRP-NHEtNameLeuprolideNature of peptide or cargoNot mentionedAssayIontophoresis permetaion studiesTissue permeabilitySerum luteinizing hormone concentration was measured 12 times during an 8 hr period. Significant elevations of LH were seen in active compared with passive patches.(56.4 +- 49.6 mIU/ml) at 4hrs.Tissue Samplehuman skinPUBMED ID3143511
ID1651SequencePyroGlu-HWSYGLRPGNameLeuteinzing hormone releasing hormone(LHRH)Nature of peptide or cargoNot mentionedAssaySingle antibody radioimmunoassayTissue permeabilityThe total amount of LHRH delivered during the 5h was 959 +- 444 ng.Tissue Sampleold female yorkshire pigsPUBMED ID8360818