| PRIMARY INFORMATION |
|---|
| ID | 1638 |
| PMID | 3143511 |
| Year | 1988 |
| Sequence | pyroGHWSYlRP-NHEt |
| Name | Leuprolide |
| Length | 9 |
| N-Terminal Modification | Et |
| C-Terminal Modification | pyroGlutamine |
| Linear/ Cyclic | Linear |
| Chirality | Mix |
| Chemical Modification | Et |
| Origin of Peptide | Synthetic |
| Nature of Peptide/Cargo | Not mentioned |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | No cargo |
Name of cargo
| Not applicable |
| Assay | Iontophoresis permetaion studies |
| Enhancer | Trans-dermal patches contain 0.2 mA |
| Properties of enhancer | Not mentioned |
| Concentration | 5mg in the form of transdermal patches |
| Incubation time | 8 hours |
| Tissue permeability (value with units) | Serum luteinizing hormone concentration was measured 12 times during an 8 hr period. Significant elevations of LH were seen in active compared with passive patches.(56.4 +- 49.6 mIU/ml) at 4hrs. |
| Tissue Sample | human skin |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
