Welcome to Entry Card of Peptide
Details of TopicalPdb ID 1624
| PRIMARY INFORMATION |
|---|
| ID | 1624 |
| PMID | 2121407 |
| Year | 1990 |
| Sequence | pyroGHWSYlRP-NHEt |
| Name | Leuprolide (Lupron) |
| Length | 9 |
| N-Terminal Modification | Et |
| C-Terminal Modification | pyroGlutamine |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | Et |
| Origin of Peptide | Synthetic |
| Nature of Peptide/Cargo | It is a useful model peptide for evaluating transdermal administration of peptide drugs. |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | No cargo |
Name of cargo
| Not applicable |
| Assay | Amerlex LH RIA kit |
| Enhancer | 0.22uA current |
| Properties of enhancer | To induce transdermal absorption of a drug |
| Concentration | 5mg |
| Incubation time | 1 week |
| Tissue permeability (value with units) | From the transdermal route the peak response was 76.9 ± 99.8 mIU/ ml |
| Tissue Sample | Human skin |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
