| ID | 1624 | |
| PMID | 2121407 | |
| Year | 1990 | |
| Sequence | pyroGHWSYlRP-NHEt | |
| Name | Leuprolide (Lupron) | |
| Length | 9 | |
| N-Terminal Modification | Et | |
| C-Terminal Modification | pyroGlutamine | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | Et | |
| Origin of Peptide | Synthetic | |
| Nature of Peptide/Cargo | It is a useful model peptide for evaluating transdermal administration of peptide drugs. | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | No cargo | |
| Name of cargo | Not applicable | |
| Assay | Amerlex LH RIA kit | |
| Enhancer | 0.22uA current | |
| Properties of enhancer | To induce transdermal absorption of a drug | |
| Concentration | 5mg | |
| Incubation time | 1 week | |
| Tissue permeability (value with units) | From the transdermal route the peak response was 76.9 ± 99.8 mIU/ ml | |
| Tissue Sample | Human skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N.A. | |