A database of FDA approved therapeutic peptides and proteins
ID | ThPPID | Name | Peptide Sequence | Length | Functional Classification | Disease | Brand | Company | Physical Appearance | Route of Administartion | Category | Target |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1400 | Th1064 | Muromonab | Heavy Chain: QVQLQQS Full view | 664 | IIa | Immunological | ORTHOCLONE OKT3 STERILE SOLUTION | Centocor Ortho Biotech, L.P. | Sterile Solution is a murine monoclonal antibody to the CD3 antigen of human T cells which functions as an immunosuppressant. | For Intravenous Use Only | Immunologic Factors and Immunosuppressive Agents | N.A. |
1406 | Th1066 | Ibritumomab | Heavy Chain: QAYLQQS Full view | 652 | IIb | Cancer | Zevalin | Spectrum Pharmaceuticals | Clear, colorless, sterile, pyrogen-free, preservative-free solution that may contain translucent particles. | Intravenous infusion | N.A. | Digoxin |
1412 | Th1068 | Tositumomab | Heavy Chain 1: QAYLQ Full view | 1351 | IIb | Cancer | Bexxar | Galaxo Smith Kline | Sterile, pyrogen-free, clear to opalescent, colorless to slightly yellow, preservative-free solution | Intravenous(IV) administration | N.A. | Bacterial outer membrane,Lipoteichoic acid synthesis |
1431 | Th1073 | Alemtuzumab | Heavy Chain 1: QVQLQ Full view | 2839 | IIa | Cancer | CAMPATH | Genzyme Corporation | Sterile, clear, colorless, isotonic solution (pH 6.8-7.4) | Intravenous infusion | N.A. | N.A. |
1432 | Th1073 | Alemtuzumab | Heavy Chain 1: QVQLQ Full view | 2389 | IIa | Cancer | LEMTRADA | Genzyme Corporation | LEMTRADA is a sterile, clear and colorless to slightly yellow, solution (pH 7.2±0.2) for infusion. | Intravenous infusion | NA | NA |
1434 | Th1074 | Alglucerase | ARPCIPKSFGYSSVVCVCNA Full view | 497 | Ia | Metabolic | Ceredase | Genzyme Corporation | Clear sterile non-pyrogenic solution of alglucerase in a citrate buffered solution | Intravenous injection | Enzyme Replacement Agents | Plasminogen,Proteinase-activated receptor 1 |
1435 | Th1075 | Capromab | N.A. Full view | 0 | IV | Cancer | ProstaScint | Jazz Pharmaceuticals, Inc. | Sterile, pyrogen-free, clear, colorless solution that may contain some translucent particles. | Intravenous injection | Indicators, Reagents and Diagnostic Agents | CAMPATH-1 antigen,Low affinity immunoglobulin gamma Fc region receptor III-B,Complement C1r subcomponent,Complement C1q subcomponent subunit A,Complement C1q subcomponent subunit B,Complement C1q subcomponent subunit C,Low affinity immunoglobulin gamma Fc region receptor III-A,High affinity immunoglobulin gamma Fc receptor I,Low affinity immunoglobulin gamma Fc region receptor II-a,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor II-c |
1437 | Th1076 | Laronidase | APHLVQVDAARALWPLRRFW Full view | 626 | Ia | Metabolic | ALDURAZYME | Genzyme Corporation | Sterile, nonpyrogenic, colorless to pale yellow, clear to slightly opalescent solution that must be diluted prior to administration in 0.9% Sodium Chloride Injection | Intravenous infusion | Enzyme Replacement Agents | N.A. |
1456 | Th1086 | Interferon Alfa-2B, Recombinant | CDLPQTHSLGSRRTLMLLAQ Full view | 165 | Ib | Immunological | INTRON® A | Merck | Powder or solution | Intramuscular, Subcutaneous, Intralesional, or Intravenous injection | Immunosuppressive Agents | Granulocyte colony-stimulating factor receptor,Neutrophil elastase, Coagulation factor X,Coagulation factor XI,Coagulation factor VII,Coagulation factor VIII,Prothrombin,Prolow-density lipoprotein receptor-related protein 1,Vitamin K-dependent gamma-carboxylase, Platelet-derived growth factor receptor beta,Platelet-derived growth factor receptor alpha,Alpha-2-macroglobulin |
1460 | Th1087 | Oxytocin | CYIQNCPLG Full view | 9 | Ib | Hormonal | Pitocin | JHP Pharmaceuticals | Sterile, clear, colorless aqueous solution of synthetic oxytocin | Intravenous infusion | Oxytocics, Anti-tocolytic Agents and Labor Induction Agents | Interferon alpha/beta receptor 2,Interferon alpha/beta receptor 1, Globotriaosylceramide |
1465 | Th1089 | Palivizumab | VH region: QVTLRESG< Full view | 120 | IIIa | Infectious | Synagis | MedImmune | Sterile, preservative-free liquid solution | Intramuscular injection | Antiviral Agents | N.A. |
1468 | Th1091 | Bevacizumab | DIQMTQSPSSLSASVGDRVT Full view | 214 | IIa | Cardiac | Avastin | Genentech | Slightly opalescent, colorless to pale brown, sterile, pH 6.2 solution for intravenous infusion | Intravenous infusion | Angiogenesis Inhibitors | Interleukin-2 receptor subunit alpha,Interleukin-2 receptor subunit beta,Low affinity immunoglobulin gamma Fc region receptor III-B,Complement C1r subcomponent,Complement C1q subcomponent subunit A,Complement C1q subcomponent subunit B,Complement C1q subcomponent subunit C,Low affinity immunoglobulin gamma Fc region receptor III-A,High affinity immunoglobulin gamma Fc receptor I,Low affinity immunoglobulin gamma Fc region receptor II-a,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor II-c |
1473 | Th1093 | Eculizumab | N.A. Full view | 0 | Ia | Haemetological | Soliris | Alexion, Inc | Sterile, clear, colorless, preservative-free 10 mg/mL solution for intravenous infusion | N.A. | N.A. | Complement C5 |
1475 | Th1095 | Ranibizumab | Light Chain SASQDISN Full view | 447 | IIa | Hematological/Eye Disorder | Lucentis | Genentech | Sterile, colorless to pale yellow solution | Intravitreal injection | Ophthalmics | Vascular endothelial growth factor A |
1476 | Th1096 | Idursulfase | SETQANSTTDALNVLLIIVD Full view | 525 | Ia | Metabolic | Elaprase | SHIRE | Sterile, nonpyrogenic clear to slightly opalescent, colorless solution that must be diluted prior to administration in 0.9% Sodium Chloride Injection, USP | Intravenous infusion | Enzyme Replacement Agents | Dermatan sulfate,Heparan sulfate,Perilipin-3 |
1482 | Th1100 | Pramlintide | KCNTATCATQRLANFLVHSS Full view | 37 | Ia | Hormonal/Metabolic | Symlin | Amylin Pharmaceuticals (now a wholly owned subsidiary of AstraZeneca) | Clear, isotonic, sterile solution | Subcutaneous injection | N.A. | Calcitonin receptor,Receptor activity-modifying protein 1,Receptor activity-modifying protein 2,Receptor activity-modifying protein 3 |
1494 | Th1101 | Galsulfase | SGAGASRPPHLVFLLADDLG Full view | 497 | Ia | Metabolic | Naglazyme | BioMarin | Sterile, nonpyrogenic, colorless to pale yellow, clear to slightly opalescent solution that must be diluted with 0.9% Sodium Chloride Injection, USP, prior to administration | Intravenous infusion | Enzyme Replacement Agents | Dermatan sulfate,Perilipin-3 |
1502 | Th1105 | Insulin Aspart | A chain: GIVEQCCTSIC Full view | 51 | Ia | Hormonal/Metabolic | NovoLog | Novo Nordisk | Sterile, aqueous, clear, and colorless solution | Subcutaneous injection, Intravenous injection | Hypoglycemic Agents and Antidiabetic Agents | Insulin receptor |
1511 | Th1106 | Insulin Detemir | A chain: GIVEQCCTSIC Full view | 51 | Ia | Hormonal/Metabolic | LEVEMIR | Novo Nordisk | Clear, colorless, aqueous, neutral sterile solution | Subcutaneous injection | Antidiabetic Agents | Insulin receptor |
1520 | Th1107 | Insulin Glulisine | A chain: GIVEQCCTSIC Full view | 51 | Ib | Hormonal/Metabolic | APIDRA | sanofi-aventis | Sterile, aqueous, clear, and colorless solution | N.A. | Antidiabetic Agents | Insulin receptor |
1529 | Th1108 | Pegaptanib | N.A. Full view | 0 | IIa | Hematological/Eye Disorder | Macugen | Gilead Sciences | Sterile, aqueous solution containing pegaptanib sodium for intravitreous injection | Intravitreal injection | Intended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS. | N.A. |
1534 | Th1113 | Glatiramer Acetate | EAYKAAEKAYAAKEAAKEAA Full view | 52 | IIa | Neurological Disorder | Copaxone | Teva Pharmaceutical Industries | Clear, colorless to slightly yellow, sterile, nonpyrogenic solution | Subcutaneous injection | N.A. | N.A. |
1548 | Th1117 | Ipilimumab | Heavy chain: QVQLVES Full view | 663 | IIIc | Cancer | YERVOY | Bristol-Myers Squibb | Sterile, preservative-free, clear to slightly opalescent, colorless to pale-yellow solution | N.A. | Antineoplastic Agents and Monoclonal antibodies | Cytotoxic T-lymphocyte protein 4 |
1550 | Th1119 | Tocilizumab | N.A. Full view | 0 | IIa | Immunological | ACTEMRA | Genentech | Sterile, preservative-free solution, colorless to pale yellow liquid, with a pH of about 6.5 | Intravenous infusion, Subcutaneous injection | N.A. | Interleukin-6 receptor subunit alpha |
1556 | Th1120 | Teriparatide | Parathyroid hormone Full view | 34 | Ib | Osteological | Forteo | Eli Lilly and Company | Sterile, colorless, clear, isotonic solution | Subcutaneous injection | Bone Density Conservation Agents | Parathyroid hormone/parathyroid hormone-related peptide receptor |
1570 | Th1123 | Denosumab | Heavy chain EVQLLESG Full view | 664 | IIIc | Osteological | Xgeva | Amgen. | Sterile, preservative-free, clear, colorless to pale yellow solution | N.A. | Bone Density Conservation Agents and Monoclonal antibodies | Tumor necrosis factor ligand superfamily member 11 |
1571 | Th1123 | Denosumab | Heavy chain EVQLLESG Full view | 664 | IIIc | Osteological | Prolia | Amgen. | Sterile, preservative-free, clear, colorless to pale yellow solution | N.A. | Bone Density Conservation Agents and Monoclonal antibodies | Tumor necrosis factor ligand superfamily member 11 |
1576 | Th1124 | Liraglutide | HAEGTFTSDVSSYLEGQAAK Full view | 33 | Ib | Hormonal | Saxenda | Novo Nordisk | Clear, colorless solution | Subcutaneous injection | N.A. | Glucagon-like peptide 1 receptor |
1577 | Th1124 | Liraglutide | HAEGTFTSDVSSYLEGQAAK Full view | 33 | Ib | Hormonal | Victoza | Novo Nordisk | Clear, colorless solution. | Subcutaneous injection | N.A. | Glucagon-like peptide 1 receptor |
1583 | Th1125 | Golimumab | N.A. Full view | 0 | IIb | Immunological | Simponi Injection | N.A. | Clear to slightly opalescent, colorless to light yellow solution | Subcutaneous injection | Antipsoriatic Agents and Monoclonal antibodies and TNF inhibitor | Tumor necrosis factor |
1584 | Th1125 | Golimumab | N.A. Full view | 0 | IIb | Immunological | Simponi Injection | N.A. | Sterile concentrated solution of the golimumab antibody | Intravenous infusion | Antipsoriatic Agents and Monoclonal antibodies and TNF inhibitor | Tumor necrosis factor |
1600 | Th1127 | Buserelin | N.A. Full view | 0 | IIIc | Cancer/Hormonal | Suprecur (Nasal Spray Solution) | Sanofi-Aventis | 150 micrograms Nasal Spray Solution | Nasal spray | N.A. | Lutropin-choriogonadotropic hormone receptor,Gonadotropin-releasing hormone receptor |
1615 | Th1133 | Aflibercept | SDTGRPFVEMYSEIPEIIHM Full view | 431 | Ib | Cancer | Eylea | Regeneron Pharmaceuticals | Sterile, clear, and colorless to pale yellow solution. | Intravitreal injection | Antineoplastic Agents and Ophthalmics | Vascular endothelial growth factor A,Placenta growth factor,Vascular endothelial growth factor B |
1616 | Th1133 | Aflibercept | SDTGRPFVEMYSEIPEIIHM Full view | 431 | Ib | Cancer | Zaltrap | Sanofi and Regeneron Pharmaceuticals, Inc. | Sterile, clear, colorless to pale yellow, non-pyrogenic, preservative-free, solution. | Intravenous infusion | Antineoplastic Agents and Ophthalmics | Vascular endothelial growth factor A,Placenta growth factor,Vascular endothelial growth factor B |
1622 | Th1135 | Ocriplasmin | Truncated heavy chai Full view | 251 | Ic | Eye Disorder | Jetrea | ThromboGenics NV | Sterile, clear and colorless solution with no preservatives | Intravitreal injection | Ophthalmics | Fibronectin,Alpha-2-macroglobulin,Alpha-2-antiplasmin |
1628 | Th1139 | Certolizumab Pegol | Light chain: DIQMTQS Full view | 443 | IIb | Immunologcal | Cimzia | UCB | Sterile, white, lyophilized powder for solution or as a sterile, solution in a single-use prefilled 1 mL glass syringe | Subcutaneous injection | TNF inhibitor | Tumor necrosis factor |
1635 | Th1141 | Epoetin Zeta | APPRLICDSRVLERYLLEAK Full view | 166 | Ib | Cancer | Retacrit | Norbitec | solution for injection | N.A. | N.A. | Erythropoietin receptor |
1654 | Th1150 | Secukinumab | Secukinumab Heavy Ch Full view | 672 | IIa | Immunological | Cosentyx | Novartis Pharmaceuticals Corporation | Sterile, preservative-free, clear to slightly opalescent, colorless to slightly yellow solution. | Subcutaneous injection | Inhibitor | IL-17A cytokine |
1667 | Th1158 | Aprotinin | RPDFCLEPPYTGPCKARIIR Full view | 58 | IIa | Immunological | Trasylol | Bayer Pharmaceuticals | Clear, colorless, sterile isotonic solution | Intravenous administration | N.A. | Trypsin-1, Chymotrypsinogen B, Plasminogen, Kallikrein-! |
1674 | Th1161 | Albiglutide | HGEGTFTSDVSSYLEGQAAK Full view | 645 | Ib | Hormonal disorders | Eperzan | Glaxosmithkline Inc | Powder for Solution | Subcutaneous | Drugs used in diabetes; alimentary tract and metabolism; blood glucose lowering drugs, excl. insulins. | Glucagon-like peptide 1 receptor |
1676 | Th1161 | Albiglutide | HGEGTFTSDVSSYLEGQAAK Full view | 645 | Ib | Hormonal disorders | Tanzeum | Glaxo Smith Kline Llc | Injection, Powder, Lyophilized, for Solution | Subcutaneous | Drugs used in diabetes; alimentary tract and metabolism; blood glucose lowering drugs, excl. insulins. | Glucagon-like peptide 1 receptor |
1678 | Th1162 | Alirocumab | NA Full view | 0 | Ic | Metabolic/Cardiac | Praluent | Sanofi Aventis U.S. Llc | Injection, Solution | Subcutaneous | N.A. | Proprotein convertase subtilisin/kexin type 9 |
1679 | Th1162 | Alirocumab | NA Full view | 0 | Ic | Metabolic/Cardiac | Praluent | Sanofi Aventis Canada Inc | Solution | Subcutaneous | N.A. | Proprotein convertase subtilisin/kexin type 10 |
1680 | Th1162 | Alirocumab | NA Full view | 0 | Ic | Metabolic/Cardiac | Praluent | Sanofi Aventis Canada Inc | Solution | Subcutaneous | N.A. | Proprotein convertase subtilisin/kexin type 11 |
1681 | Th1162 | Alirocumab | NA Full view | 0 | Ic | Metabolic/Cardiac | Praluent | Sanofi Aventis U.S. Llc | Injection, Solution | Subcutaneous | N.A. | Proprotein convertase subtilisin/kexin type 14 |
1684 | Th1164 | Antithrombin Alfa | NA Full view | 0 | Ia | Hematological Disorders | Atryn | Gtc Biotherapeutics, Inc. | Injection, Powder, Lyophilized, for Solution | Intravenous | NA | NA |
1685 | Th1164 | Antithrombin Alfa | NA Full view | 0 | Ia | Hematological Disorders | Atryn | R Evo Bioloigics, Inc. | Injection, Powder, Lyophilized, for Solution | Intravenous | NA | NA |
1688 | Th1165 | Antithrombin III human | NA Full view | 0 | Ia | Hematological Disorders | Thrombate III | Grifols Therapeutics Inc | Powder for Solution | NA | NA | NA |
1691 | Th1165 | Antithrombin III human | NA Full view | 0 | Ia | Hematological Disorders | Thrombate III Pws IV 1000iu/vial | Miles Inc. Pharmaceutical Division | Powder for Solution | NA | NA | NA |
1694 | Th1166 | Asfotase Alfa | LVPEKEKDPKYWRDQAQETL Full view | 726 | Ia | Genetic Disorders | Strensiq | Alexion Pharma Ghbh | Solution | Subcutaneous | Enzymes Alimentary Tract and Metabolism | Sphingosine 1-phosphate receptor 1; Pyrophosphate |