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Details of SAPdb entry with Sequence LL

Primary information
SAPdb ID	1442,
PMID	24085660
Peptide Name	Fmoc-LL
Peptide sequence	LL
N-Terminal Modification	Fmoc [or N-(fluorenyl-9-methoxycarbonyl)]
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	Transmission Electron Microscopy (TEM) and WAXS(Wide Angle X - Ray scattering)
Solvent	Water + 0.1M Hcl + 0.5 M NaOH
Method	Fmoc-dipeptide was suspended in water. Sodium hydroxide (0.5 M) was gradually added to the aqueous suspensions of Fmoc-dipeptide until pH 10.5 was reached. The samples were vortexed and sonicated for one minute to fully dissolve the peptide amphiphiles. To obtain required pH, a required volume of dilute hydrochloric acid (0.085 M) was then added dropwise to the solution. Solution sonicated and vortexed. Next, the samples were heated to 75â€šÃ„Ã¬80 â€šÃ³Â¶C until fully dissolved and homogenised. The samples were subsequently cooled and maintained at 4 â€šÃ³Â¶C for â€šÃ Âº 12 hours (overnight) to promote gelation.
Conc	10mmol/L
Temperature	8 - 10.5
Temperature	4 Â°C
Incubation Time	~ 12 hours
Year	2013
Self assembly	No
Type of Self assembly	No hydogel formation
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	None
	NA
	LL
	N.A.

Primary information
SAPdb ID	1443,
PMID	24085660
Peptide Name	Fmoc-LL
Peptide sequence	LL
N-Terminal Modification	Fmoc [or N-(fluorenyl-9-methoxycarbonyl)]
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	Transmission Electron Microscopy (TEM) and WAXS(Wide Angle X - Ray scattering)
Solvent	Water + 0.1M Hcl + 0.5 M NaOH
Method	Fmoc-dipeptide was suspended in water. Sodium hydroxide (0.5 M) was gradually added to the aqueous suspensions of Fmoc-dipeptide until pH 10.5 was reached. The samples were vortexed and sonicated for one minute to fully dissolve the peptide amphiphiles. To obtain required pH, a required volume of dilute hydrochloric acid (0.085 M) was then added dropwise to the solution. Solution sonicated and vortexed. Next, the samples were heated to 75â€šÃ„Ã¬80 â€šÃ³Â¶C until fully dissolved and homogenised. The samples were subsequently cooled and maintained at 4 â€šÃ³Â¶C for â€šÃ Âº 12 hours (overnight) to promote gelation.
Conc	10mmol/L
Temperature	4.3 - 6.8
Temperature	4 Â°C
Incubation Time	~ 12 hours
Year	2013
Self assembly	Yes
Type of Self assembly	Nanofibers
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Nanofiber
	NA
	LL
	N.A.

Primary information
SAPdb ID	1478,
PMID	22651803
Peptide Name	Dipeptide6
Peptide sequence	LL
N-Terminal Modification	Napthalene
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	Scanning Electron Microscopy (SEM) and X - Ray Diffraction
Solvent	Water + 0.1 M NaOH
Method	25mg of dipeptide was suspended in deionized 5ml water . An equimolar amount of NaOH (0.1 M,aq) was added, and the solution was gently stirred until a clear solution was formed. Glucono-Å’Â¥- lactone (GdL) was added to the solution and the samples were gently swirled to dissolve the GdL before being left to stand for 24 h without stirring to form gel.
Conc	5mg/ml or 0.5%wt
Temperature	Room temperature
Incubation Time	24 hours
Year	2012
Self assembly	Yes
Type of Self assembly	Turbid gel
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Hydrogel
	NA
	LL
	N.A.

Primary information
SAPdb ID	1607,
PMID	21085503
Peptide Name	(S,S)-bis(LeuLeu) or 1a
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	Transmission Electron Microscopy (TEM)
Solvent	Water/DMSO
Method	10 mg peptide placed in a test tube, and the solvent was added by microsyringe in 100-500 Â¬ÂµL portions. After each addition the mixture was gently heated until the substance dissolved, and was then allowed to cool spontaneously to room temperature and formation of gel. checked by test tube inversion.
Temperature	Room temperature
Year	2010
Self assembly	Yes
Type of Self assembly	Straight fibers
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Nanofiber
	70
	LL
	N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O

Primary information
SAPdb ID	1608,
PMID	21085503
Peptide Name	(S,R)-bis(LeuLeu) or 1a
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	Transmission Electron Microscopy (TEM)
Solvent	Water/DMSO
Method	10 mg peptide placed in a test tube, and the solvent was added by microsyringe in 100-500 Â¬ÂµL portions. After each addition the mixture was gently heated until the substance dissolved, and was then allowed to cool spontaneously to room temperature and formation of gel. checked by test tube inversion.
Temperature	Room temperature
Incubation Time	Yes
Year	2010
Self assembly	Yes
Type of Self assembly	Fibers
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Nanofiber
	30
	LL
	N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O

Primary information
SAPdb ID	1609,
PMID	21085503
Peptide Name	(S,R)-bis(LeuLeu) or 1a
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Methyaltion
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	Transmission Electron Microscopy (TEM)
Solvent	Toluene
Method	10 mg peptide placed in a test tube, and the solvent was added by microsyringe in 100-500 Â¬ÂµL portions. After each addition the mixture was gently heated until the substance dissolved, and was then allowed to cool spontaneously to room temperature and formation of gel. checked by test tube inversion.
Temperature	Room temperature
Incubation Time	Yes
Year	2010
Self assembly	Yes
Type of Self assembly	Tapes
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	Stable
	Nanotape
	NA
	LL
	N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O

Primary information
SAPdb ID	1636,
PMID	24895323
Peptide Name	Dileucine
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	ESEM (Environmental Scanning Electron Microscope)
Solvent	HFP (1,1,1,3,3,3-hexafluoro-2-propanol)
Method	FF-peptide nanotubes (PNT) were prepared by dissolving the L-diphenylalanine peptide in 1,1,1,3,3,3-hexafluoro-2-propanol an initial concentration of 100mg/ml further diluted in deionized water. Drops of the above solutions at a final concentrationof 2mg/ml were placed onto clean silicon substrates and dried at room temperature.The thermally induced LL PNT samples were heated in an oven for 90min at 180 Â¬âˆžC.
Conc	2mg/ml
Temperature	Room temperature
Incubation Time	90 minutes
Year	2014
Self assembly	Yes
Type of Self assembly	Nanotubes
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Nanotube
	NA
	LL
	N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O

Primary information
SAPdb ID	1637,
PMID	24895323
Peptide Name	Dileucine
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	ESEM (Environmental Scanning Electron Microscope)
Solvent	HFP (1,1,1,3,3,3-hexafluoro-2-propanol)
Method	FF-peptide nanotubes (PNT) were prepared by dissolving the L-diphenylalanine peptide in 1,1,1,3,3,3-hexafluoro-2-propanol an initial concentration of 100mg/ml further diluted in deionized water. Drops of the above solutions at a final concentrationof 2mg/ml were placed onto clean silicon substrates and dried at room temperature.The thermally induced LL PNT samples were heated in an oven for 90min at 180 Â¬âˆžC.
Conc	2mg/ml
Temperature	180 Â°C
Incubation Time	> 90 minutes
Year	2014
Self assembly	Yes
Type of Self assembly	Needle like wire -Nanofibril structure
Tertiary Structure (Technique)	Not Predicted),
	Linear
	Temperature induced
	NA
	Nanofiber, Nanowire
	NA
	LL
	N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O

Primary information
SAPdb ID	1888,
PMID	27841381
Peptide Name	dileucine (LL)
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	TEM and SEM
Year	2016
Self assembly	Yes
Type of Self assembly	Nanoparticles
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Other
	NA
	LL
	N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Primary information
SAPdb ID	1917,
PMID	28440566
Peptide Name	Boc-Leu-beta 3,3 -Ac6c-Leu-beta 3,3-Ac6c-OMe, P2
Peptide sequence	LL
N-Terminal Modification	Boc (or t-butoxycarbonyl)
C-Terminal Modification	Methoxy
Non-Terminal Modification	1-Amino- cyclohexane acetic acid (beta3,3-Ac6c)
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Solvent	ethyl acetate/hexane
Conc	8:2
Year	2017
Self assembly	No
Type of Self assembly	NA
Tertiary Structure (Technique)	Not Predicted),
	NA
	NA
	NA
	NA
	NA
	LL
	N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Primary information
SAPdb ID	1926,
PMID	28508902
Peptide Name	L-leucyl-L-leucine (Leu-Leu)
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	atomic force microscopy and X-ray powder diffraction
Solvent	methanol/n-butanol and methanol/acetonitrile
Conc	1:01
Temperature	Room temperature
Incubation Time	3 days
Year	2017
Self assembly	Yes
Type of Self assembly	Nanofibres
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Nanofiber
	NA
	LL
	N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Primary information
SAPdb ID	1941,
PMID	28589640
Peptide Name	Boc-D-Leu-L-Leu-OMe
Peptide sequence	LL
N-Terminal Modification	Boc (or t-butoxycarbonyl)
C-Terminal Modification	Methoxy
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	SEM, circular dichroism, attenuated total internal reflection-fourier transform infrared spectroscopy, X-ray diffraction and microscopy
Solvent	Methanol (MeOH), trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP)
Conc	6 mM
Temperature	Room temperature
Incubation Time	30 min
Year	2017
Self assembly	Yes
Type of Self assembly	long cylinders
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	long cylinders
	NA
	LL
	N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

Primary information
SAPdb ID	1986,
PMID	28820260
Peptide Name	L-leucyl-L-leucine
Peptide sequence	LL
N-Terminal Modification	Free
C-Terminal Modification	Free
Non-Terminal Modification	None
Length	2
Peptide/Conjuagate	Peptide
Conjugate partner	None
Technique	AFM, NMR spectrometry, FTIR spectroscopy and GC-MS
Temperature	180 Â°C
Year	2017
Self assembly	NA
Type of Self assembly	Nanotubes
Tertiary Structure (Technique)	Not Predicted),
	Linear
	NA
	NA
	Nanotube
	NA
	LL
	N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O