Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1724	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJW3.fasta	B3DJW3	1057	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1724	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJW3.fasta	B3DJW3	1057	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1725	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QMN8.fasta	F1QMN8	989	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1725	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QMN8.fasta	F1QMN8	989	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1727	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1727	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1728	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1728	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1739	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5a/b (TLR5a/b)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	NA	NA	NA	induce IFN expression	NA	27721456	2016	NA
PRRID_1739	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5a/b (TLR5a/b)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	NA	NA	NA	induce IFN expression	NA	27721456	2016	NA
PRRID_1757	Lipopeptides Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1757	Lipopeptides Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1774	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	EcToll-like receptor (TLR1b)	Toll-like receptor (TLR)	Zebrafish	spleen and head kidney	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1774	Lipopolysaccharide (LPS) Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	EcToll-like receptor (TLR1b)	Toll-like receptor (TLR)	Zebrafish	spleen and head kidney	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1831	NA Click for more detail	viral hemorrhagic septicemia (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	EcToll-like receptor 2b (TLR2b)	Toll-like receptor (TLR)	Zebrafish	Gills and spleen	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1831	NA Click for more detail	viral hemorrhagic septicemia (virus)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	EcToll-like receptor 2b (TLR2b)	Toll-like receptor (TLR)	Zebrafish	Gills and spleen	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1832	NA Click for more detail	C. irritans (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	EcToll-like receptor 14 (TLR14)	Toll-like receptor (TLR)	Zebrafish	Gills and spleen	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1832	NA Click for more detail	C. irritans (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	EcToll-like receptor 14 (TLR14)	Toll-like receptor (TLR)	Zebrafish	Gills and spleen	leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain.	NA	NA	NA	Activate NF-Kb	NA	27037219	2016	NA
PRRID_1837	Pam3CSk4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1837	Pam3CSk4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	F1QWS9.fasta	F1QWS9	818	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1847	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1847	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Zebrafish	Plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B8JIL3.fasta	B8JIL3	903	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1848	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1848	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	B3DJL6.fasta	B3DJL6	947	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1877	TLR1‚ÄìTLR2 heterodimer Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Zebrafish	plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	A0A0R4IW15.fasta	A0A0R4IW15	795	induce IFN expression	NA	27721456	2016	Pubchem_assay
PRRID_1877	TLR1‚ÄìTLR2 heterodimer Click for more detail	NA	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Zebrafish	plasma membrane	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	A0A0R4IW15.fasta	A0A0R4IW15	795	induce IFN expression	NA	27721456	2016	Pubchem_assay