Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_2011	dsRNA Click for more detail	MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)	NA	NA	Nucleic Acid	Natural	dsRNA induced dimerization	NA	NA	solanaceous	NA	NA	NA	NA	NA	TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jB	NA	28374903	2017	NA
PRRID_2011	dsRNA Click for more detail	MCMV, HSV-1, EMCV, WNV,and enteroviruses (virus)	NA	NA	Nucleic Acid	Natural	dsRNA induced dimerization	NA	NA	solanaceous	NA	NA	NA	NA	NA	TRIF-TRAF3-TBK1/ IKKe-IRF3. TRIF-TRAF6- IKKs-NF-jB	NA	28374903	2017	NA
PRRID_2012	dsRNA Click for more detail	flu virus, SeV and bacteria	NA	NA	Nucleic Acid	Natural	potassium efflux-NEK7 involved NLRP3 inflammasome complex	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Cytoplasm. Ubiquitously expressed	NA	Q96P20.fasta	Q96P20	1036	ASC-inflammasome- caspase-1-IL-1/IL-18	NA	28374903	2017	Pubchem_assay
PRRID_2012	dsRNA Click for more detail	flu virus, SeV and bacteria	NA	NA	Nucleic Acid	Natural	potassium efflux-NEK7 involved NLRP3 inflammasome complex	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	Cytoplasm. Ubiquitously expressed	NA	Q96P20.fasta	Q96P20	1036	ASC-inflammasome- caspase-1-IL-1/IL-18	NA	28374903	2017	Pubchem_assay
PRRID_2013	dsRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2013	dsRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2018	endogenous nucleic acids Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2018	endogenous nucleic acids Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2019	endogenous nucleic acids Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2019	endogenous nucleic acids Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2316	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Pf_Toll-like receptor (TLR18)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2316	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Pf_Toll-like receptor (TLR18)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2319	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Pf_Toll-like receptor 19 (TLR19)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2319	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Pf_Toll-like receptor 19 (TLR19)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2347	mt-DNA Click for more detail	All vertebrates(others)	NA	NA	Nucleic Acid	Natural	Cellular injury and necrosis	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Granulocytes and monocytes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NRN6	154	release of interferon type 1 and TNF-a through the activation of IL-1R-associated kinase 1, 2, and 4 and the phosphorylation of p38 MAPK	NA	28049142	2017	Pubchem_assay
PRRID_2347	mt-DNA Click for more detail	All vertebrates(others)	NA	NA	Nucleic Acid	Natural	Cellular injury and necrosis	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Granulocytes and monocytes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NRN6	154	release of interferon type 1 and TNF-a through the activation of IL-1R-associated kinase 1, 2, and 4 and the phosphorylation of p38 MAPK	NA	28049142	2017	Pubchem_assay
PRRID_2348	mt-DNA Click for more detail	Mitochondria (others)	NA	NA	Nucleic Acid	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29290139	2017	Pubchem_assay
PRRID_2348	mt-DNA Click for more detail	Mitochondria (others)	NA	NA	Nucleic Acid	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29290139	2017	Pubchem_assay
PRRID_2355	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Pf_Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	LRR and TIR domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2355	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Pf_Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Pelteobagrus fulvidraco	isolated peripheral blood lymphocytes	LRR and TIR domain	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28546018	2017	NA
PRRID_2548	IRS 945 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29039348	2017	Pubchem_assay
PRRID_2548	IRS 945 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29039348	2017	Pubchem_assay
PRRID_2558	polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT]) Click for more detail	Bacteria	CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2558	polydeoxyadenylic:polydeoxyt hymidylic acid (poly[dA:dT]) Click for more detail	Bacteria	CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O.C1C(C(OC1N2C=NC3=C2N=CN=C3N)COP(=O)(O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2559	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29353310	2017	Pubchem_assay
PRRID_2559	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29353310	2017	Pubchem_assay
PRRID_2560	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	RIG-1	Pattern recognition receptor (PRR)	bat cell line	Cytosol	NA	NA	NA	NA	NA	RT-qPCR	29122634	2017	NA
PRRID_2560	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	RIG-1	Pattern recognition receptor (PRR)	bat cell line	Cytosol	NA	NA	NA	NA	NA	RT-qPCR	29122634	2017	NA
PRRID_2561	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	MDA5	Rig-like receptor (RLR)	bat cell line	Cytosol	NA	NA	NA	NA	NA	RT-qPCR	29122634	2017	NA
PRRID_2561	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	NA	MDA5	Rig-like receptor (RLR)	bat cell line	Cytosol	NA	NA	NA	NA	NA	RT-qPCR	29122634	2017	NA
PRRID_2562	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	anti- inflammatory activity	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29113797	2017	Pubchem_assay
PRRID_2562	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	anti- inflammatory activity	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	U937 cells	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	29113797	2017	Pubchem_assay
PRRID_2563	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	innate immunity elicitor	CgLRRIG-1	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2563	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	innate immunity elicitor	CgLRRIG-1	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2564	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	innate immunity elicitor	CgLRRIG-2	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2564	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	innate immunity elicitor	CgLRRIG-2	Pattern recognition receptor (PRR)	oyster Crassostrea gigas	Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas.	Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain	NA	NA	NA	immune effectors or pro-inflammatory factors as well as PRRs in oyster.	PAMPs binding assay	28889011	2017	NA
PRRID_2565	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2565	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	The classic signaling cascade generated by RIG-I commences to the C-terminal repressor domain, followed by recruitment of mitochondrial antiviral signaling protein through homophilic interactions between CARD domains.	RIG-1	Rig-like receptor (RLR)	Human	Cytoplasm	Carbohydrate recognition domain (CRD)	O95786.fasta	O95786	925	NF-Œ∫B-mediated in ammatory cytokine pro- duction.	NA	28776416	2017	Pubchem_assay
PRRID_2566	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Activation of CLRs.	CaNTC	C type Lectin (CTL/CLR)	Carassius auratus	Liver	Carbohydrate recognition domain (CRD)	NA	NA	NA	pathogen recognition in Qihe 538 crucian carp	Microbial binding assay	28602683	2017	NA
PRRID_2566	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Activation of CLRs.	CaNTC	C type Lectin (CTL/CLR)	Carassius auratus	Liver	Carbohydrate recognition domain (CRD)	NA	NA	NA	pathogen recognition in Qihe 538 crucian carp	Microbial binding assay	28602683	2017	NA
PRRID_2567	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	tbToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Scophthalmus maximus	Liver and spleen	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	ELISA	28495564	2017	NA
PRRID_2567	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	tbToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Scophthalmus maximus	Liver and spleen	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	ELISA	28495564	2017	NA
PRRID_2568	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2568	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2569	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2569	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Trachinotus ovatus	Spleen and Kidney	25 leucine-rich repeat (LRR) motifs, a transmembrane domain and a 28 TIR motif	NA	NA	NA	activate NF-Œ∫B.	qRT-PCR	28232281	2017	NA
PRRID_2570	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	CcToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Cyprinus carpio L	All tested tissue	A signal peptide, 16 LRR domains, a LRRCT domain in the extracellular region and a TIR domain.	NA	NA	NA	activate NF-Œ∫B.	RT-qPCR	28192255	2017	NA
PRRID_2570	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	CcToll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Cyprinus carpio L	All tested tissue	A signal peptide, 16 LRR domains, a LRRCT domain in the extracellular region and a TIR domain.	NA	NA	NA	activate NF-Œ∫B.	RT-qPCR	28192255	2017	NA
PRRID_2591	RNA Click for more detail	Type B coxsackieviruses (CVBs) (others)	NA	NA	Nucleic Acid	Natural	myocarditis and acute pancreatitis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	NA	NA	28973047	2017	Pubchem_assay
PRRID_2591	RNA Click for more detail	Type B coxsackieviruses (CVBs) (others)	NA	NA	Nucleic Acid	Natural	myocarditis and acute pancreatitis	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	NA	NA	28973047	2017	Pubchem_assay
PRRID_2593	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q99MB1.fasta	Q99MB1	905	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2593	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q99MB1.fasta	Q99MB1	905	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2594	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	P58681.fasta	P58681	1050	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2594	RNA Click for more detail	Brucella abortus(Bacteria)	NA	NA	Nucleic Acid	Natural	On stimulation, production of significant amount of proinflammatory cytokibes such as IL-12, IL-6, IP-10/CXCL10 and TNF-‚ç∫.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	P58681.fasta	P58681	1050	This has immunostimulatory effect which leads to the clearance of pathogen from the host system.	ELISA	28167945	2017	Pubchem_assay
PRRID_2617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29066255	2017	Pubchem_assay
PRRID_2617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29066255	2017	Pubchem_assay
PRRID_2618	single-stranded RNA Click for more detail	exogenous viruses (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	cellular endosomal compartments,	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2618	single-stranded RNA Click for more detail	exogenous viruses (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	cellular endosomal compartments,	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29052054	2017	Pubchem_assay
PRRID_2619	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	29038956	2017	Pubchem_assay
PRRID_2619	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	29038956	2017	Pubchem_assay
PRRID_2620	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	NA	NA	29038956	2017	Pubchem_assay
PRRID_2620	single-stranded RNA Click for more detail	Borrelia spp(Bacteria)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	NA	NA	29038956	2017	Pubchem_assay
PRRID_2621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Induce production of inflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	airway and lung epithelial Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29028369	2017	Pubchem_assay
PRRID_2621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Induce production of inflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	airway and lung epithelial Cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	NA	NA	29028369	2017	Pubchem_assay
PRRID_2622	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29028369	2017	Pubchem_assay
PRRID_2622	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	NA	NA	29028369	2017	Pubchem_assay
PRRID_2623	single-stranded RNA Click for more detail	Respiratory syncytial virus (virus)	NA	NA	Nucleic Acid	Natural	Respiratory syncytial virus infection, activation of NOD2.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2623	single-stranded RNA Click for more detail	Respiratory syncytial virus (virus)	NA	NA	Nucleic Acid	Natural	Respiratory syncytial virus infection, activation of NOD2.	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2624	single-stranded RNA Click for more detail	Vesicular stomatitis (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2624	single-stranded RNA Click for more detail	Vesicular stomatitis (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2625	single-stranded RNA Click for more detail	Parainfluenza (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2625	single-stranded RNA Click for more detail	Parainfluenza (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2626	single-stranded RNA Click for more detail	Influenza A (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2626	single-stranded RNA Click for more detail	Influenza A (virus)	NA	NA	Nucleic Acid	Natural	Activation of NOD2	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	Cellular level	nucleotide-binding oligomerization domain	Q8K3Z0.fasta	Q8K3Z0	1020	Activation of Type I interferon via detection of ssRNA	NA	28823510	2017	Pubchem_assay
PRRID_2627	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2627	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosomes. pDCs and B cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2628	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2628	single-stranded RNA Click for more detail	SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus)	NA	NA	Nucleic Acid	Natural	Z-loop proteolytic cleavage, and receptor dimer conformational change	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosomes. Monocytes, macrophages and cDCs	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB	NA	28374903	2017	Pubchem_assay
PRRID_2629	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2629	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2630	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2630	single-stranded RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2663	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	cytoplasm	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29263932	2017	Pubchem_assay
PRRID_2663	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	cytoplasm	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	29263932	2017	Pubchem_assay
PRRID_2686	viral double stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2686	viral double stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2687	viral double stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	MDA5	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2687	viral double stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	MDA5	Rig-like receptor (RLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2689	Viral RNA Click for more detail	RSV, IAV, and HCMV (virus)	NA	NA	Nucleic Acid	Natural	Likely tetramerization into washer- locker structure	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	Cytoplasm. Macrophages, monocytes, Paneth cells, DCs	NA	Q9HC29.fasta	Q9HC29	1040	NA	NA	28374903	2017	Pubchem_assay
PRRID_2689	Viral RNA Click for more detail	RSV, IAV, and HCMV (virus)	NA	NA	Nucleic Acid	Natural	Likely tetramerization into washer- locker structure	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	Cytoplasm. Macrophages, monocytes, Paneth cells, DCs	NA	Q9HC29.fasta	Q9HC29	1040	NA	NA	28374903	2017	Pubchem_assay
PRRID_2731	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor (TLR19)	Toll-like receptor (TLR)	Grass Carp (Ctenopharyngodon idella)	internal membrane.	LRR,TIR domain	NA	NA	NA	NA	Luciferase assay	29229676	2018	NA
PRRID_2731	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor (TLR19)	Toll-like receptor (TLR)	Grass Carp (Ctenopharyngodon idella)	internal membrane.	LRR,TIR domain	NA	NA	NA	NA	Luciferase assay	29229676	2018	NA

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