Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1724 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B3DJW3.fasta | B3DJW3 | 1057 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1724 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B3DJW3.fasta | B3DJW3 | 1057 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1725 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 21 (TLR21) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QMN8.fasta | F1QMN8 | 989 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1725 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 21 (TLR21) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QMN8.fasta | F1QMN8 | 989 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1727 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B8JIL3.fasta | B8JIL3 | 903 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1727 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B8JIL3.fasta | B8JIL3 | 903 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1728 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B3DJL6.fasta | B3DJL6 | 947 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1728 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B3DJL6.fasta | B3DJL6 | 947 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1739 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Immunostimulant | Toll-like receptor 5a/b (TLR5a/b) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | NA | NA | NA | induce IFN expression | NA | 27721456 | 2016 | NA |
| PRRID_1739 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Immunostimulant | Toll-like receptor 5a/b (TLR5a/b) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | NA | NA | NA | induce IFN expression | NA | 27721456 | 2016 | NA |
| PRRID_1757 | Lipopeptides Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QWS9.fasta | F1QWS9 | 818 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1757 | Lipopeptides Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QWS9.fasta | F1QWS9 | 818 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1774 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | EcToll-like receptor (TLR1b) | Toll-like receptor (TLR) | Zebrafish | spleen and head kidney | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1774 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | EcToll-like receptor (TLR1b) | Toll-like receptor (TLR) | Zebrafish | spleen and head kidney | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1831 | NA Click for more detail | viral hemorrhagic septicemia (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | EcToll-like receptor 2b (TLR2b) | Toll-like receptor (TLR) | Zebrafish | Gills and spleen | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1831 | NA Click for more detail | viral hemorrhagic septicemia (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | EcToll-like receptor 2b (TLR2b) | Toll-like receptor (TLR) | Zebrafish | Gills and spleen | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1832 | NA Click for more detail | C. irritans (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | EcToll-like receptor 14 (TLR14) | Toll-like receptor (TLR) | Zebrafish | Gills and spleen | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1832 | NA Click for more detail | C. irritans (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | EcToll-like receptor 14 (TLR14) | Toll-like receptor (TLR) | Zebrafish | Gills and spleen | leucine-rich repeat (LRR) domains (including an LRR-NT (except for EcTLR1b), several LRR motifs and an LRR-CT), a trans-membrane region and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | Activate NF-Kb | NA | 27037219 | 2016 | NA |
| PRRID_1837 | Pam3CSk4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QWS9.fasta | F1QWS9 | 818 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1837 | Pam3CSk4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QWS9.fasta | F1QWS9 | 818 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1847 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B8JIL3.fasta | B8JIL3 | 903 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1847 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B8JIL3.fasta | B8JIL3 | 903 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1848 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B3DJL6.fasta | B3DJL6 | 947 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1848 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Zebrafish | endosomes and lysosomes. | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | B3DJL6.fasta | B3DJL6 | 947 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1877 | TLR1–TLR2 heterodimer Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Zebrafish | plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | A0A0R4IW15.fasta | A0A0R4IW15 | 795 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1877 | TLR1–TLR2 heterodimer Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Zebrafish | plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | A0A0R4IW15.fasta | A0A0R4IW15 | 795 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |