Result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay | Pdb | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| PRRID_0101 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | NLRC3 | NLR | Human | cytoplasm | Untypical CARD | Q7RTR2.fasta | Q7RTR2 | 1065 | NA | NA | 29353310 | 2018 | NA | PRR_0101.pdb| PRRID_0102 | CpG-ODN | Click for more detail Bacteria | NA | NA | Nucleic Acid | Synthetic | induction of the antiviral protein Mx | TLR9 | TLR | Atlantic salmon (Salmo salar) | muscle, head kidney, liver, gut, heart, spleen and gill | NA | A8SZH4.fasta | A8SZH4 | 1074 | strong induction of IL-1b and IFN-a1 | Real-time PCR | 24736205 | 2014 | NA | PRR_0102.pdb | PRRID_0103 | citric acid | Click for more detail NA | NA | NA | NA | Natural | used to evoke cough in preclinical and clinical studies | Transient receptor potential ankyrin1 (TRPA1) | Transient receptor potential ankyrin1 (TRPA1) | Guinea Pig | neuronal as well as non-neuronal cells of the respiratory tract | NA | E3VTL3.fasta | E3VTL3 | 1111 | Sensor of a wide range of environmental irritants. | Real-time RT-PCR, Calcium influx assay | 24819048 | 2014 | NA | PRR_0103.pdb | PRRID_0104 | NA | Click for more detail NA | NA | NA | NA | Natural | NA | CIITA | NLR | Human | Nucleus | NA | P33076.fasta | P33076 | 1130 | NA | NA | 29353310 | 2018 | NA | PRR_0104.pdb | PRRID_0105 | MDP (muramyldipeptide) | Click for more detail Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | NLRP1 | NLR | Mice | cortical neurons (cell culture, stroke model) | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | NA | PRR_0105.pdb | PRRID_0106 | NA | Click for more detail NA | NA | NA | NA | NA | NA | NLRP5 | NLR | Human | cytoplasm | NA | P59047.fasta | P59047 | 1200 | NA | NA | 29353310 | 2018 | NA | PRR_0106.pdb | PRRID_0107 | MDP (muramyldipeptide) | Click for more detail Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | NLRP1 | NLR | Rat | Hippocampus | NA | D9I2G4 .fasta | D9I2G4 | 1218 | NLRP1 inflammasome activation in aging | NA | 28801521 | 2017 | NA | PRR_0107.pdb | PRRID_0108 | NA | Click for more detail IHE3034 (E.coli strain) (Bacteria) | NA | NA | PAMP | Natural | Causes inflammation and activation of SCR. | SSc5D | Scavenger receptor | Human | Macrophages | Five SRCR modules, and a large C-terminal mucin-like domain | A1L4H1.fasta | A1L4H1 | 1573 | Pathogen recognition; T cell differentiation | Microbial binding assay | 27790215 | 2016 | NA | PRR_0108.pdb | PRRID_0109 | NA | Click for more detail NA | NA | NA | NA | NA | NA | NLRC5 | NLR | Human | Nucleus | NA | Q86WI3.fasta | Q86WI3 | 1866 | NA | NA | 29353310 | 2018 | NA | PRR_0109.pdb | PRRID_0110 | Dextran Sulfate Sodium (DSS) | Click for more detail Dietary Products(others) | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O.Na | NA | Carbohydrate | Synthetic | It has the its inhibitory effects on LPS-induced TLR4-mediated NF-kappaB activation. | Deleted in malignant brain tumors 1 (DMBT1) | PRR | Mice | NA | NA | Q60997.fasta | Q60997 | 2085 | DSS inhibit DMBT1-mediated bacterial aggregation. | ELISA | 19189310 | 2009 | NA | PRR_0110.pdb | |