Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_2470Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result40% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2471Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result30% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2472Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2473Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2474Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result50% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2475Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result40% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2476Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result30% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2477Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2478Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result60% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2479Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result50% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2480Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result45% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2481Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell death after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2482Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2483Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2484Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2485Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result90% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2486Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2487Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result70% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2488Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result30% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2489Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration0.10 MOIIn-vitro result20% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2490Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result80% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2491Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result60% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2492Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2493Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result15% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2494Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-8Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2495Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2496Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result30% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2497Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result95% cell killing after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2498Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell killing after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2499Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2500Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result70% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2501Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result40% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2502Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result30% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2503Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman gastric cancer cell lineCell lineMKN-45Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result15% cell survival after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2504Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result50% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2505Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2506Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2507Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2508Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman squamous cell lineCell lineSCC-25Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2509Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result50% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2510Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2511Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2512Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2513Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman mesothelia cell lineCell lineMSTO-211Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 9Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2514Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2515Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result10% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2516Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2517Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineH1650Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2518Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result70% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2519Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result10% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2520Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result10% cell survival after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2521Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman breast cancer cell lineCell lineMDA-MB-231Concentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result10% cell survival after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2522Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result90% cell survival after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2523Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result20% cell survival after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2524Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2525Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman thyroid cancer cell lineCell line8505cConcentration of cell line3.0E+4 cells per wellIn-vitro toxicityNAAssayLDH release and spectrophometerIn-vitro virus concentration1 MOIIn-vitro result100% cell death after day 7Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2526Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenografted for PANC-1 cell line(2.0E+6 cells)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultDecrease in tumor volume below 2 after 34 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2527Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenografted for PANC-1 cell line(2.0E+6 cells)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultDecrease in tumor volume below 2 after 34 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2813Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2814Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2815Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2816Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT15Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2817Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT15Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2818Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT15Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2819Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2820Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2821Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2822Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineSW620Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2823Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineSW620Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result90% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2824Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineSW620Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2825Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineColo-205Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2826Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineColo-205Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result60% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2827Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineColo-205Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result30% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2828Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2829Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result25% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2830Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell death after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2831Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT15Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2832Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT15Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2833Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT15Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2834Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2835Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2836Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell death after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2837Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineSW620Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2838Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineSW620Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result40% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2839Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineSW620Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell death after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2840Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineColo-205Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2841Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineColo-205Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result10% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2842Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineColo-205Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cell death after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectUpregulation of immune related antigens and cytokines like IFN-gamma, IP-10, MCP-1, MCP-3Clinical trialNAPMID23531320
IDOV_2843Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenograft for HCT-116 (5.0E+6 cells)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultSignificant reduction in tumor volume after 42 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID23531320
IDOV_2867Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell line143-BConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2868Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell line143-BConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2869Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell line143-BConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2870Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell line143-BConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2871Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineORDConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2872Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineORDConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2873Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineORDConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2874Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineORDConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2875Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineHOSConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result30% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2876Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineHOSConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result20% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608
IDOV_2877Virus nameVaccinia virusVirus strainvvDDVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of TK gene and vaccinia growth factorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineOsteosarcoma cell lineCell lineHOSConcentration of cell line5.0E+3 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result10% cell survivalModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID23816608