The Total number of records shown on this page is 16. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_5359	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for 5.0E+5 PANC1	2.0E+6 pfu	NA	Reduction in tumor volume to 400 cubic mm after 60 days compared to 1000 cubic mm	Intratumoral	Virus induced apoptosis	NA	NA	28315430
OV_5360	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with Gemcitabine 1.5mg/kg	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for 3.0E+5 MIAPaCa2	2.0E+6 pfu	NA	Reduction in tumor volume to 500 cubic mm after 60 days compared to 2700 cubic mm	Intratumoral	Virus induced apoptosis	NA	NA	28315430
OV_5361	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with Gemcitabine 1.5mg/kg	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for 5.0E+5 BxPC3	2.0E+6 pfu	NA	Reduction in tumor volume to 400 cubic mm after 60 days compared to 2700 cubic mm	Intratumoral	Virus induced apoptosis	NA	NA	28315430
OV_5362	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with Gemcitabine 1.5mg/kg	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for 5.0E+5 PANC1	2.0E+6 pfu	NA	Reduction in tumor volume to 100 cubic mm after 60 days compared to 1000 cubic mm	Intratumoral	Virus induced apoptosis	NA	NA	28315430
OV_5550	Adenovirus	wild type	DNA	Adenoviridae	None	No	Virus in combination with Gancliovar (100mg/kg) after 80 hours	No	NA	Human adenocortical cell cell line	SW13	NA	NA	NA	NA	NA	Nude mice xenograft for SW13 (10E+6)	2.0E+9 pfu	NA	80% of animal survived after day 50	Intraperitoneal	NA	NA	NA	US6875610
OV_5551	Adenovirus	wild type	DNA	Adenoviridae	None	No	Virus in combination with Gancliovar (100mg/kg) after 30 hours	No	NA	Human adenocortical cell cell line	SW13	NA	NA	NA	NA	NA	Nude mice xenograft for SW13 (10E+6)	2.0E+9 pfu	NA	70% of animal survived after day 50	Intraperitoneal	NA	NA	NA	US6875610
OV_5669	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Hep3B	NA	NA	MTT assay	0.01 MOI	Complete cancer cell death	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5670	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Hep3B	NA	NA	MTT assay	1 MOI	Complete cancer cell death after day 5	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5671	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human renal epithelia cancer cell line	HRE	NA	NA	MTT assay	0.01 MOI	Complete cancer cell death	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5672	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human renal epithelia cancer cell line	HRE	NA	NA	MTT assay	1 MOI	Complete cancer cell death after day 8	No	No	NA	No response	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5673	Adenovirus	OV802	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Balb/c mice xenograft for A549 (5.0E+6 )	4.0E+8 pfu	NA	Reduction in tumor volume to below 300 after 80 days	NA	NA	Induction of IFN-Gamma, IL6 and other immunostimulatory cytokines production	NA	US7473418
OV_5891	Adenovirus	CGTG-602	DNA	Adenoviridae	Virus E1A promoter is replaced by human E2F1 promoter	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 ×10⁴ pfu	80% of cancer cell death occurs after 100 days	No	No	NA	No response	NA	NA	NA	NA	US9410129
OV_5892	Adenovirus	CGTG-602	DNA	Adenoviridae	Virus E1A promoter is replaced by human E2F1 promoter	Yes	No	No	ATCC	Human ovarian carcinoma cell line	SKOV3	NA	NA	MTT assay	1 ×10⁴ pfu	80% of cancer cell death occurs after 100 days	No	No	NA	No response	NA	NA	NA	NA	US9410129
OV_5893	Adenovirus	CGTG-602	DNA	Adenoviridae	Virus E1A promoter is replaced by human E2F1 promoter	Yes	No	No	ATCC	Human prostate cancer cell line	PC-3-MM2	NA	NA	MTT assay	1 ×10⁴ pfu	All cell death occurs after 100 days	No	No	NA	No response	NA	NA	NA	NA	US9410129
OV_5894	Adenovirus	CGTG-602	DNA	Adenoviridae	Virus E1A promoter is replaced by human E2F1 promoter	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Hamster xenograft for HAPT-1 (7.0E+6)	3.0E+8 pfu	NA	Tumor volume reduced to 300mm after 18 days compared to control 800mm	Intratumoral	NA	NA	NA	US9410129
OV_5895	Adenovirus	CGTG-602	DNA	Adenoviridae	Virus E1A promoter is replaced by human E2F1 promoter	No	Virus in combination with cyclosporin	No	NA	NA	NA	NA	NA	NA	NA	NA	Hamster xenograft for HAPT-1 (7.0E+6)	3.0E+8 pfu	NA	Tumor volume reduced to 300mm after 18 days compared to control 800mm	Intratumoral	NA	NA	NA	US9410129