Detailed description page of Selected OV_ID


OV_5362 details
Primary information
OV_IDOV_5362
Virus Name Adenovirus
StrainYDC002
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus having insertion mutant for relaxin gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with Gemcitabine 1.5mg/kg
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for 5 × 10⁵ PANC1
In-vivo virus concentration2 × 10⁶ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 100 cubic mm after 60 days compared to 1000 cubic mm
Mode of deliveryIntratumoral
Pathway inductionVirus induced apoptosis
Immunogenic effectNA
Clinical trialNA
PMID28315430