Browse By Model Organism Result Page of OvirusTdb

The total number of records retrieved from this search are 54. Click on ID to see further detail.
IDOV_5763Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1887.6mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5764Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1181.4mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5765Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 74.4mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5766Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 855.9mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5767Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1392mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5768Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 187.5mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5769Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 264.9mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5770Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 365.7mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5771Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 155.3mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5772Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 62mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5773Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 291.1mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5774Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 314.2mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5775Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 238.3mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5776Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (25mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 117.4mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5777Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 279.8mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5778Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 395.5mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5779Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 206.5mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5780Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (50mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 61mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5781Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 587.1mm compared to control 204.3 mm after 32 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5782Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 391.1mm compared to control 333.9 mm after 42 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5783Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 184mm compared to control 646.6 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5784Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneNoVirus in combination with drug/radiationVirus in combination with cidofovir (100mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 58mm compared to control 886.4 mm after 56 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5785Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 176.9 mm compared to control 278.1 after 53 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5786Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 598.8mm compared to control 755 after 63 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5787Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 668.4 mm compared to control 1169.9 after 69 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5788Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 896.6 mm compared to control 2512.7 after 77 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5789Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 298.8 after 41 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5790Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1448.3 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5791Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 2512.4 after 64 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5792Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 34.07 after 71 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5793Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 415.1 after 41 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5794Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1403.1 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5795Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1163.7 after 64 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5796Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 993 after 71 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5797Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 757.5 after 79 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5798Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 667 after 87 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5799Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 547 after 93 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5800Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 549 after 99 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5801Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 511 after 106 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5802Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 465.3 after 113 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5803Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 441.3 after 119 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5804Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 268.4 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5805Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 623.7 after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5806Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1232.5 after 70 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5807Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1277.05 after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5808Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1189.55 mm after 81 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5809Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 744.4mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5810Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 402.1 after 55 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5811Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1128.15 after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5812Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1485.05 after 70 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5813Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes to 1599.35 after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5814Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1411.4mm after 81 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5815Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1040mm after 89 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5816Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vector respectivelyVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatin (5mg/kg)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for OVCAR-3 (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 906.75 mm after 96 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968