The total number of records retrieved from this search are 40. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_268	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	20 MOI	92% cancer cell viability at 72 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_269	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	50 MOI	95% cancer cell viability at 72 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_270	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	100 MOI	92% cancer cell viability at 72 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_271	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	90% cancer cell viability at 72 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_272	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	200 MOI	88% cancer cell viability at 72 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_273	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	92% cancer cell viability at 24 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_274	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	85% cancer cell viability at 48 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_275	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	90% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_283	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	20 MOI	88% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_284	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	50 MOI	75% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_285	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	100 MOI	77% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_286	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	74% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_287	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	200 MOI	70% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_288	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	90% cancer cell viability at 24 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_289	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	83% cancer cell viability at 48 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_290	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	71% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_298	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	50 MOI	78% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_299	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	No	Virus combined with recombinant human CD47 Fc chimera (rhCD47-Fc) - 1μg/mL	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	50 MOI	82% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_300	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	No	Virus combined with recombinant human CD47 Fc chimera (rhCD47-Fc) - 5μg/mL	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	50 MOI	96% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_305	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	20 MOI	92% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_306	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	50 MOI	65% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_307	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	100 MOI	58% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_308	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	150 MOI	52% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_309	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Leukemia cell line	K562	2.0E+4 cells per well	NA	MTT assay	200 MOI	44% cancer cell viability at 72 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_753	Adenovirus	SG611	DNA	Adenoviridae	None	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	10 MOI	90% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_754	Adenovirus	SG611	DNA	Adenoviridae	None	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	40 MOI	58% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_755	Adenovirus	SG611	DNA	Adenoviridae	None	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	80 MOI	41% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_756	Adenovirus	SG611	DNA	Adenoviridae	None	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	120 MOI	36% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_757	Adenovirus	SG611	DNA	Adenoviridae	None	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	160 MOI	25% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_783	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	10 MOI	90% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_784	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	40 MOI	57% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_785	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	80 MOI	30% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_786	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	120 MOI	11% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_787	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	Yes	No	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	160 MOI	9% cancer cell viability at 96 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_813	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	No	Viral strain in combination with DNR 40 ng/ml	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	40 MOI	50% cancer cell viability at 72 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_814	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	No	Viral strain in combination with DNR 120 ng/ml	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	40 MOI	42% cancer cell viability at 72 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_821	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	No	Viral strain in combination with DNR 40 ng/ml	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	80 MOI	35% cancer cell viability at 72 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_822	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	No	Viral strain in combination with DNR 120 ng/ml	No	Gibco, Thermo Fisher Scientific, Waltham, MA, USA	Human chronic myelogenous leukemic cell line	K562	1.0E+4 cells per well	Slight toxicity to L-02 and BJ cell line	Cell counting kit-8 (CCK-8) assay	80 MOI	29% cancer cell viability at 72 hours	No	No	NA	No response	NA	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_5635	Newcastle disease virus	NDV-MK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human leukemia cell line	K562	80% confluency	NA	MTT assay	5.4 ×10⁴ pfu	50% of cancer cell death occurs	No	No	NA	No response	NA	Induction of apoptosis by virus infection	Induction of IFN-Gamma production	NA	US7470426
OV_5855	Newcastle disease virus	NDV-PPMK107	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human leukemia cell line	K562	80% confluency	NA	NA	5.4 ×10⁴ pfu	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	US8105578