| Primary information |
|---|
| OV_ID | OV_284 |
| Virus Name | Adenovirus |
| Strain | Ad.4N1 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Leukemia cell line |
| Cell line | K562 |
| Concentration of cell line | 2 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 50 MOI |
| In-vitro result | 75% cancer cell viability at 72 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Induces apoptosis by upregulating Bax and activated caspase 3 levels |
| Immunogenic effect | Induces expression of IL-24 |
| Clinical trial | NA |
| PMID | 26554307 |