| Primary information |
|---|
| OV_ID | OV_822 |
| Virus Name | Adenovirus |
| Strain | SG611-VSTM1 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1 |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Viral strain in combination with DNR 120 ng/ml |
| Immune gene induction in virus genome | No |
| Source of cell line | Gibco, Thermo Fisher Scientific, Waltham, MA, USA |
| Origin of cell line | Human chronic myelogenous leukemic cell line |
| Cell line | K562 |
| Concentration of cell line | 1 |
| In-vitro toxicity | Slight toxicity to L-02 and BJ cell line |
| Assay | Cell counting kit-8 (CCK-8) assay |
| In-vitro virus concentration | 80 MOI |
| In-vitro result | 29% cancer cell viability at 72 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Enhanced apoptosis activation is observed |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27472927 |