The total number of records retrieved from this search are 31. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_582	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.001 PFU/cell	86% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_583	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.001 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_584	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.01 PFU/cell	80% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_585	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.01 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_586	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.1 PFU/cell	70% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_587	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.1 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_588	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	1 PFU/cell	38% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_589	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	1 PFU/cell	90% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_590	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	25% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_591	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	10 PFU/cell	80% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_600	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with ESI-09 and with H89(10 μM)	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.1 PFU/cell	75% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	ESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_601	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with ESI-09	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.1 PFU/cell	82% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	ESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_2270	Vesicular stomatitis virus	wild type	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	1 MOI	40% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2284	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	1 MOI	40% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2298	Vesicular stomatitis virus	VSV-p1-GFP	RNA	Rhabdoviridae	Insertion of P gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	1 MOI	30% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2312	Vesicular stomatitis virus	Sev-GFP	RNA	Rhabdoviridae	Insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	1 MOI	50% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2326	Vesicular stomatitis virus	RSV-GFP	RNA	Rhabdoviridae	Insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	1 MOI	50% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2340	Vesicular stomatitis virus	wild type	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	0.01 MOI	5% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2354	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	0.01 MOI	2% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2368	Vesicular stomatitis virus	VSV-p1-GFP	RNA	Rhabdoviridae	Insertion of P gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	0.01 MOI	2% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2382	Vesicular stomatitis virus	Sev-GFP	RNA	Rhabdoviridae	Virus expressing GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	0.01 MOI	70% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2396	Vesicular stomatitis virus	RSV-GFP	RNA	Rhabdoviridae	Virus expressing GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	Capan-1	80% confluent monolayer	NA	MTT assay	0.01 MOI	100% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_4315	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreas adenocarcinoma	Capan-1	4000 cells per well	NA	MTT assay	10 pfu	85.1 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4353	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.001 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4354	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.01 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4355	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.1 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4356	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	10 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4357	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	100 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4361	Alphavirus	M1	RNA	Togaviridae	None	No	Virus in combination with dbcAMP 100 micromoalr	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.001 MOI	70% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4362	Alphavirus	M1	RNA	Togaviridae	None	No	Virus in combination with dbcAMP 200 micromoalr	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.01 MOI	60% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4363	Alphavirus	M1	RNA	Togaviridae	None	No	Virus in combination with dbcAMP 400 micromoalr	No	ATCC	Human pancreatic adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.1 MOI	30% cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347