The total number of records retrieved from this search are 47. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_10	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	10 MOI	70% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_11	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	50 MOI	58% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_12	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	100 MOI	38% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_13	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	10 MOI	100% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_14	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	50 MOI	95% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_15	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	100 MOI	94% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_16	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	10 MOI	77% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_17	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	50 MOI	72% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_18	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	Grown to 70% confluence	NA	MTT assay	100 MOI	58% cancer cell viability	No	No	NA	No response	NA	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_718	Avian influenza A virus	H7N3 NS1-77	RNA	Orthomyxoviridae	Mutations were introduced within the IAV NS1 gene to create a truncated protein of 77 aa (NS1-77)	Yes	No	No	NA	Human pancreatic cancer cell line	MIAPaCa-2	NA	NA	Immunoassay detection	0.001 MOI	70% cancer cell death (calculated as relative to mock-infected)	No	No	NA	No response	NA	NA	Up-regulation of IFN-aplha	NA	27417501
OV_722	Avian influenza A virus	H7N3	RNA	Orthomyxoviridae	None	Yes	No	No	NA	Human pancreatic cancer cell line	MIAPaCa-2	NA	NA	Immunoassay detection	0.001 MOI	90% cancer cell death (calculated as relative to mock-infected)	No	No	NA	No response	NA	NA	Up-regulation of IFN-aplha	NA	27417501
OV_2272	Vesicular stomatitis virus	wild type	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	1 MOI	100% cell death after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2286	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	1 MOI	100% cell death after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2300	Vesicular stomatitis virus	VSV-p1-GFP	RNA	Rhabdoviridae	Insertion of P gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	1 MOI	100% cell death after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2314	Vesicular stomatitis virus	Sev-GFP	RNA	Rhabdoviridae	Insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	1 MOI	2% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2328	Vesicular stomatitis virus	RSV-GFP	RNA	Rhabdoviridae	Insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	1 MOI	20% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2342	Vesicular stomatitis virus	wild type	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	0.01 MOI	2% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2356	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	0.01 MOI	2% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2370	Vesicular stomatitis virus	VSV-p1-GFP	RNA	Rhabdoviridae	Insertion of P gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	0.01 MOI	2% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2384	Vesicular stomatitis virus	Sev-GFP	RNA	Rhabdoviridae	Virus expressing GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	0.01 MOI	70% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2398	Vesicular stomatitis virus	RSV-GFP	RNA	Rhabdoviridae	Virus expressing GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	80% confluent monolayer	NA	MTT assay	0.01 MOI	90% cell survival after 5 days	No	No	NA	No response	NA	NA	Downregulation of IFN-Gamma	NA	22238308
OV_2408	Vesicular stomatitis virus	VSV-Delta-M51-GFP	RNA	Rhabdoviridae	Deletion of M51 gene and insertion of GFP gene	Yes	No	No	ATCC	Pancreatic ductal adeonocarcinoma cell line	MIAPaCa-2	NA	NA	NA	NA	NA	Athymic mice xenograft for MIA PaCa2 cell line	5.0E+7 pfu	NA	Reduction in tumor weight below 5 mg after 25 days	Intratumoral	NA	Downregulation of IFN-Gamma	NA	22238308
OV_3409	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.1 MOI	No cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3410	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.25 MOI	No cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3411	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.5 MOI	No cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3412	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.75 MOI	28% cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3413	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	Yes	No	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	1 MOI	25% cell killing after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3426	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with gemcitabine 3 × 10⁻² micromolar) after 1 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.5 MOI	50% of tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3427	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with gemcitabine (3 × 10⁻² micromolar) after 24 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.5 MOI	75% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3434	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (5 × 10⁻³ micromolar) after 1 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.5 MOI	50% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3435	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (5 × 10⁻³ micromolar) after 24 hour	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.5 MOI	75% of the tumor cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3446	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (15 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.5 MOI	60% cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3447	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (15 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	0.75 MOI	55% cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3448	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (15 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	SRB assay	1 MOI	55% cell mass remain after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3449	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (15 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	CTB assay	0.5 MOI	50% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3450	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (15 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	CTB assay	0.75 MOI	45% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_3451	Vaccinia virus	GLV-1h68	DNA	Poxviridae	Insertion of three gene beta-glucouronidase, galactosidase and GFP	No	Virus in combination with nab-palcitaxel (2.5 nM)and gemcitabine (15 nM)	No	ATCC	Human pancreatic adenocarcinoma cell line	MIAPaCa-2	4.0E+4 cells per well	NA	CTB assay	1 MOI	40% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	28607950
OV_4296	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreas carcinoma	MIAPaCa-2	4000 cells per well	NA	MTT assay	10 pfu	49.1 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_5345	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	1 MOI	78% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5346	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	2 MOI	78% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5347	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.01 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	1 MOI	60% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5348	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.01 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	2 MOI	50% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5349	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.05 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	1 MOI	35% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5350	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.05 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	2 MOI	30% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5561	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	MIAPaCa-2	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5566	Reovirus	wild type	RNA	Reoviridae	None	Yes	No	No	NA	Human pancreatic cell line	MIAPaCa-2	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5571	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	MIAPaCa-2	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2