| HMRbase accession number | 10346 |
| Swiss-prot Accession number | Q99NF2 (Sequence in FASTA format) |
| Description | Nasal embryonic luteinizing hormone-releasing hormone factor (Nasalembryonic LHRH factor) (Juxtasynaptic attractor of caldendrin ondendritic boutons protein) (Jacob protein). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; peripheral membrane protein. Note=Found on the outside of the LHRH cell membrane and axons projecting from the olfactory pit and epithelium |
| Developmental Stage | At E14.5 embryo found with high level within the forebrain, olfactory epithelium and olfactory pit. At E12.5 embryo detected on olfactory axons including olfactory pathway on which the LHRH neurons move. From E11.5 to E17.5 embryos expressed in LHRH (luteinizing hormone-releasing hormone) neurons as they migrate from the olfactory pit into the developing forebrain. |
| Similarity | N/A |
| Tissue Specificity | Expressed in adult brain and liver. In the brain expressed in the cortex, hippocampus, olfactory bulb and thalamus |
| Post translational modification | N/A |
| Function | Influences outgrowth of olfactory axons and migration of LHRH neurons |
| Protein Length | 532 Amino acids |
| Molecular weight | 60293 |
| References | 1 PubMed abstract 10898796
2 Dieterich D.C., Hoffmann B., Seidenbecher C.I., Kreutz M.R.; "Characterization of the novel brain-specific protein Jacob."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
3 PubMed abstract 16141072
4 PubMed abstract 15489334
5 PubMed abstract 15018815
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| Domain Name | N/A |
| Hormone Name | Nasal embryonic luteinizing hormone-releasing hormone factor |
| Mature Hormone Sequence | MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADAYSGHDGSPEMQPAPQNKRRLSLVSNGRYEGSISDEAVSGKPAIEGPQPHVYTISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWAGSRQGSKECPGCAQLVPGPSSRAFGLEQPPLPEAPGRHKKLERMYSVDGVSDDVPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKGLEAMACNTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFDDVL |
| Position of mature hormone in Pre-Hormone protein | 532 Residues from position (1-532) |
| Receptor | Q01776
Detail in HMRbase
|
| Gene ID | 56876 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors